28 oktober 2012: onderaan toegevoegd het abstract van een volledig studierapport: Green tea compound in chemoprevention of cervical cancer  dat de effecten van een groene thee extract  beschrijft bij bestrijding van het HPV virus en baarmoederkanker en baarmoederhalskanker.

23 mei 2011: Nu de Gezondheidsraad adviseert om vrouwen eerst te testen op het HPV virus en dan pas verder te kijken op aanwezigheid van baarmoederhalskanker lijkt ook onderstaand artikel over effect van groene thee capsules zinvol onder de aandacht te brengen.

23 januari 2006: Bron: Eur J Cancer Prev. 2003 Oct;12(5):383-90.

Groene thee, gebruikt in vorm van capsules (polyphenon E and EGCG), werkt hoog significant beschermend en genezend tegen voorstadia van baarmoederhalskanker bij vrouwen die al geinfecteerd zijn met HPV virus. Dit blijkt uit een gerandomiseerde studie bij 51 patiënten en een controlegroep van 39 patiënten. Overall werd in de groep die groene thee extract kreeg een response gezien van 69% (bij 35 van de 51) tegen 10% in de controlegroep 4 van de 39) (P<0.05). De resultaten tonen aan dat de toediening van capsules groene thee effectief zijn in een behandeling van voorstadia van baarmoederhalskanker en groene thee kan een potentieel behandelingsprotocol zijn voor bestrijden van patiënten besmet met het HPV virus.

Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions.

Ahn WS, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, Bae SM, Lee IP.
Department of Obstetrics and Gynaecology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ahnws@catholic.ac.kr

We investigated clinical efficacy of green tea extracts (polyphenon E; poly E and (-)-epigallocatechin-3-gallate ) delivered in a form of ointment or capsule in patients with human papilloma virus (HPV) infected cervical lesions. Fifty-one patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups, as compared with 39 untreated patients as a control. Poly E ointment was applied locally to 27 patients twice a week. For oral delivery, a 200 mg of poly E or EGCG capsule was taken orally every day for eight to 12 weeks. In the study, 20 out of 27 patients (74%) under poly E ointment therapy showed a response. Six out of eight patients under poly E ointment plus poly E capsule therapy (75%) showed a response, and three out of six patients (50%) under poly E capsule therapy showed a response. Six out of 10 patients (60%) under EGCG capsule therapy showed a response. Overall, a 69% response rate (35/51) was noted for treatment with green tea extracts, as compared with a 10% response rate (4/39) in untreated controls (P<0.05). Thus, the data collected here demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 14512803 [PubMed - indexed for MEDLINE]

Green tea compound in chemoprevention of cervical cancer

2010 May;20(4):617-24.

Green tea compound in chemoprevention of cervical cancer.


Guangxi Medical University, Nanning City, China.



Human papillomavirus (HPV) infection is closely associated with the development of more than 95% of cervical cancer. Clinical trials using several chemopreventive agents are underway, but results are inconclusive. Most agents used in trials inhibited the growth of cancer cells in vitro, and about half of patients had some degree of clinical responses; however, the therapeutic effect was confounded by high rates of spontaneous regression and relapse. The selection of nontoxic agents especially food, beverage, and natural products that suppress oncogenic HPV, inhibit malignant transformation, and can additionally be used long term may be important for cervical cancer prevention.


We evaluated green tea compound (epigallocatechin gallate and polyphenols E) effects on immortalized cervical epithelial and cervical cancer cells. HPV-immortalized cervical epithelial cells, TCL1, and HPV-positive cervical cancer cells, Me180 and HeLa, were used in the study. The effects of green tea compounds on cell growth, apoptosis, cell cycle, and gene expression were examined and characterized.


Both epigallocatechin gallate and polyphenols E inhibited immortalized cervical epithelial and cancer cell growth. Apoptosis induction and cell cycle changes were observed in a dose-dependent manner. Western blot analysis of apoptosis-related proteins, p53 and p21, showed dose-dependent increase, whereas p27 was not affected. HPV-E7 protein expression was decreased by green tea compounds.


This study provides information on the potential mechanisms of action of green tea compounds in suppression of HPV-related cervical cells, and it will enable us to assess the feasibility of using these agents.


1. North A, South C. Cancer Incidence in Antartica (1998–2008) In: Curado M, Edwards B, HR S, Storm H, Ferlay J, Heanue M, et al., editors. Cancer Incidence in Five Continents. Lyon: IARC Scientific Publications No. 160; 2007.
2. American Cancer Society. Cancer Facts and Figures 2007. Atlanta: American Cancer Society; 2007.
3. Pisani P, Parkin DM, Ferlay J. Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden. Int J Cancer. 1993;55(6):891–903. [PubMed]
4. Alvarez RD, Conner MG, Weiss H, Klug PM, Niwas S, Manne U, et al. The efficacy of 9-cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: results of a randomized double-blind clinical trial. Cancer Epidemiol Biomarkers Prev. 2003;12(2):114–119. [PubMed]
5. Mitchell MF, Hittelman WK, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, et al. Chemoprevention trials and surrogate end point biomarkers in the cervix. Cancer. 1995;76(10 Suppl):1956–1977. [PubMed]
6. Johnson IT. Phytochemicals and cancer. Proc Nutr Soc. 2007;66(2):207–215. [PubMed]
7. Lee MJ, Wang ZY, Li H, Chen L, Sun Y, Gobbo S, et al. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev. 1995;4(4):393–399. [PubMed]
8. Mukhtar H, Ahmad N. Green tea in chemoprevention of cancer. Toxicol Sci. 1999;52(2 Suppl):111–117. [PubMed]
9. Yang CS, Wang ZY. Tea and cancer. J Natl Cancer Inst. 1993;85(13):1038–1049. [PubMed]
10. Yang GY, Liao J, Kim K, Yurkow EJ, Yang CS. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis. 1998;19(4):611–616. [PubMed]
11. Ahn WS, Huh SW, Bae SM, Lee IP, Lee JM, Namkoong SE, et al. A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression. DNA Cell Biol. 2003;22(3):217–224. [PubMed]
12. Ahn WS, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, et al. Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. Eur J Cancer Prev. 2003;12(5):383–390. [PubMed]
13. Issa AY, Volate SR, Muga SJ, Nitcheva D, Smith T, Wargovich MJ. Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model. Carcinogenesis. 2007;28(9):1978–1984. [PubMed]
14. Li WG, Li QH, Tan Z. Epigallocatechin gallate induces telomere fragmentation in HeLa and 293 but not in MRC-5 cells. Life Sci. 2005;76(15):1735–1746. [PubMed]
15. Yokoyama M, Noguchi M, Nakao Y, Pater A, Iwasaka T. The tea polyphenol, (-)-epigallocatechin gallate effects on growth, apoptosis, and telomerase activity in cervical cell lines. Gynecol Oncol. 2004;92(1):197–204. [PubMed]
16. Murugan RS, Mohan KV, Uchida K, Hara Y, Prathiba D, Nagini S. Modulatory effects of black tea polyphenols on oxidant-antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. J Gastroenterol. 2007;42(5):352–361. [PubMed]
17. Zou C, Vlastos AT, Yang L, Wang J, Nishioka K, Follen M. Effects of difluoromethylornithine on growth inhibition and apoptosis in human cervical epithelial and cancerous cell lines. Gynecol Oncol. 2002;85(2):266–273. [PubMed]
18. Doll R. An overview of the epidemiological evidence linking diet and cancer. Proc Nutr Soc. 1990;49(2):119–131. [PubMed]
19. Ames BN, Gold LS. The prevention of cancer. Drug Metab Rev. 1998;30(2):201–223. [PubMed]
20. Ames BN, Gold LS. The causes and prevention of cancer: the role of environment. Biotherapy. 1998;11(2–3):205–220. [PubMed]
21. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer. 1992;18(1):1–29. [PubMed]
22. Chen D, Daniel KG, Kuhn DJ, Kazi A, Bhuiyan M, Li L, et al. Green tea and tea polyphenols in cancer prevention. Front Biosci. 2004;9:2618–2631. [PubMed]
23. Katiyar SK, Mukhtar H. Tea antioxidants in cancer chemoprevention. J Cell Biochem Suppl. 1997;27:59–67. [PubMed]
24. Kohlmeier L, Weterings KG, Steck S, Kok FJ. Tea and cancer prevention: an evaluation of the epidemiologic literature. Nutr Cancer. 1997;27(1):1–13. [PubMed]
25. Murray MT. Rev. & expanded. 2nd ed. Rocklin, CA: Prima Pub.; 1995. The healing power of herbs: the enlightened person's guide to the wonders of medicinal plants.
26. Lin JK, Liang YC, Lin-Shiau SY. Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem Pharmacol. 1999;58(6):911–915. [PubMed]
27. Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. Bmj. 1995;310(6981):693–696. [PMC free article] [PubMed]
28. Imai K, Suga K, Nakachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med. 1997;26(6):769–775. [PubMed]
29. Fesus L, Szondy Z, Uray I. Probing the molecular program of apoptosis by cancer chemopreventive agents. J Cell Biochem Suppl. 1995;22:151–161. [PubMed]
30. Hartwell LH, Kastan MB. Cell cycle control and cancer. Science. 1994;266(5192):1821–1828. [PubMed]
31. Jiang MC, Yang-Yen HF, Yen JJ, Lin JK. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutr Cancer. 1996;26(1):111–120. [PubMed]
32. Reddy BS, Wang CX, Samaha H, Lubet R, Steele VE, Kelloff GJ, et al. Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. Cancer Res. 1997;57(3):420–425. [PubMed]
33. Samaha HS, Kelloff GJ, Steele V, Rao CV, Reddy BS. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res. 1997;57(7):1301–1305. [PubMed]
34. Yang CS, Chen L, Lee MJ, Balentine D, Kuo MC, Schantz SP. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol Biomarkers Prev. 1998;7(4):351–354. [PubMed]
35. Yamamoto T, Hsu S, Lewis J, Wataha J, Dickinson D, Singh B, et al. Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells. J Pharmacol Exp Ther. 2003;307(1):230–236. [PubMed]
36. Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 1999;283(5406):1321–1325. [PubMed]
37. Multani AS, Ozen M, Narayan S, Kumar V, Chandra J, McConkey DJ, et al. Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia. 2000;2(4):339–345. [PMC free article] [PubMed]
38. Ramirez R, Carracedo J, Jimenez R, Canela A, Herrera E, Aljama P, et al. Massive telomere loss is an early event of DNA damage-induced apoptosis. J Biol Chem. 2003;278(2):836–842. [PubMed]
39. Noguchi M, Yokoyama M, Watanabe S, Uchiyama M, Nakao Y, Hara K, et al. Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines. Cancer Lett. 2006;234(2):135–142. [PubMed]
40. Ahmad N, Cheng P, Mukhtar H. Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate. Biochem Biophys Res Commun. 2000;275(2):328–334. [PubMed]
41. Gupta S, Ahmad N, Nieminen AL, Mukhtar H. Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells. Toxicol Appl Pharmacol. 2000;164(1):82–90. [PubMed]
42. Gupta S, Hussain T, Mukhtar H. Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys. 2003;410(1):177–185. [PubMed]
43. Schoelch ML, Regezi JA, Dekker NP, Ng IO, McMillan A, Ziober BL, et al. Cell cycle proteins and the development of oral squamous cell carcinoma. Oral Oncol. 1999;35(3):333–342. [PubMed]
44. Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol. 2000;36(3):256–263. [PubMed]
45. Gartel AL, Serfas MS, Tyner AL. p21--negative regulator of the cell cycle. Proc Soc Exp Biol Med. 1996;213(2):138–149. [PubMed]
46. Ortega S, Malumbres M, Barbacid M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta. 2002;1602(1):73–87. [PubMed]
47. Pavletich NP. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J Mol Biol. 1999;287(5):821–828. [PubMed]
48. Davies R, Hicks R, Crook T, Morris J, Vousden K. Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation. J Virol. 1993;67(5):2521–2528. [PMC free article] [PubMed]
49. Dyson N, Howley PM, Munger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 1989;243(4893):934–937. [PubMed]
50. Watanabe S, Sato H, Komiyama N, Kanda T, Yoshiike K. The E7 functions of human papillomaviruses in rat 3Y1 cells. Virology. 1992;187(1):107–114. [PubMed]
51. Zerfass K, Schulze A, Spitkovsky D, Friedman V, Henglein B, Jansen-Durr P. Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J Virol. 1995;69(10):6389–6399. [PMC free article] [PubMed]
52. Lee SH, Kim JW, Oh SH, Kim YJ, Rho SB, Park K, et al. IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. FEBS Lett. 2005;579(5):1027–1033. [PubMed]

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1 Reactie op "Baarmoederhalskanker: Groene thee, gebruikt in vorm van capsules (polyphenon E and EGCG), werkt significant beschermend en genezend tegen voorstadia van baarmoederhalskanker bij vrouwen die al geinfecteerd zijn met HPV virus."

  • Bernadett :
    Na minsten 15 jaar HPV en meerdere foute PAPs eindelijk 'schoon' na een jaartje goene thee extract. Heel blij!

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