28 oktober 2012: onderaan toegevoegd het abstract van een volledig studierapport: Green tea compound in chemoprevention of cervical cancer dat de effecten van een groene thee extract beschrijft bij bestrijding van het HPV virus en baarmoederkanker en baarmoederhalskanker.

23 mei 2011: Nu de Gezondheidsraad adviseert om vrouwen eerst te testen op het HPV virus en dan pas verder te kijken op aanwezigheid van baarmoederhalskanker lijkt ook onderstaand artikel over effect van groene thee capsules zinvol onder de aandacht te brengen.

23 januari 2006: Bron: Eur J Cancer Prev. 2003 Oct;12(5):383-90.

Groene thee, gebruikt in vorm van capsules (polyphenon E and EGCG), werkt hoog significant beschermend en genezend tegen voorstadia van baarmoederhalskanker bij vrouwen die al geinfecteerd zijn met HPV virus. Dit blijkt uit een gerandomiseerde studie bij 51 patiënten en een controlegroep van 39 patiënten. Overall werd in de groep die groene thee extract kreeg een response gezien van 69% (bij 35 van de 51) tegen 10% in de controlegroep 4 van de 39) (P<0.05). De resultaten tonen aan dat de toediening van capsules groene thee effectief zijn in een behandeling van voorstadia van baarmoederhalskanker en groene thee kan een potentieel behandelingsprotocol zijn voor bestrijden van patiënten besmet met het HPV virus.

Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions.

Ahn WS, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, Bae SM, Lee IP.
Department of Obstetrics and Gynaecology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ahnws@catholic.ac.kr

We investigated clinical efficacy of green tea extracts (polyphenon E; poly E and (-)-epigallocatechin-3-gallate ) delivered in a form of ointment or capsule in patients with human papilloma virus (HPV) infected cervical lesions. Fifty-one patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups, as compared with 39 untreated patients as a control. Poly E ointment was applied locally to 27 patients twice a week. For oral delivery, a 200 mg of poly E or EGCG capsule was taken orally every day for eight to 12 weeks. In the study, 20 out of 27 patients (74%) under poly E ointment therapy showed a response. Six out of eight patients under poly E ointment plus poly E capsule therapy (75%) showed a response, and three out of six patients (50%) under poly E capsule therapy showed a response. Six out of 10 patients (60%) under EGCG capsule therapy showed a response. Overall, a 69% response rate (35/51) was noted for treatment with green tea extracts, as compared with a 10% response rate (4/39) in untreated controls (P<0.05). Thus, the data collected here demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 14512803 [PubMed - indexed for MEDLINE]

Green tea compound in chemoprevention of cervical cancer

Int J Gynecol Cancer. 2010 May;20(4):617-24.

Green tea compound in chemoprevention of cervical cancer.

Zou C, Liu H, Feugang JM, Hao Z, Chow HH, Garcia F.

Source

Guangxi Medical University, Nanning City, China.

Abstract

OBJECTIVES:

Human papillomavirus (HPV) infection is closely associated with the development of more than 95% of cervical cancer. Clinical trials using several chemopreventive agents are underway, but results are inconclusive. Most agents used in trials inhibited the growth of cancer cells in vitro, and about half of patients had some degree of clinical responses; however, the therapeutic effect was confounded by high rates of spontaneous regression and relapse. The selection of nontoxic agents especially food, beverage, and natural products that suppress oncogenic HPV, inhibit malignant transformation, and can additionally be used long term may be important for cervical cancer prevention.

METHODS:

We evaluated green tea compound (epigallocatechin gallate and polyphenols E) effects on immortalized cervical epithelial and cervical cancer cells. HPV-immortalized cervical epithelial cells, TCL1, and HPV-positive cervical cancer cells, Me180 and HeLa, were used in the study. The effects of green tea compounds on cell growth, apoptosis, cell cycle, and gene expression were examined and characterized.

RESULTS:

Both epigallocatechin gallate and polyphenols E inhibited immortalized cervical epithelial and cancer cell growth. Apoptosis induction and cell cycle changes were observed in a dose-dependent manner. Western blot analysis of apoptosis-related proteins, p53 and p21, showed dose-dependent increase, whereas p27 was not affected. HPV-E7 protein expression was decreased by green tea compounds.

CONCLUSIONS:

This study provides information on the potential mechanisms of action of green tea compounds in suppression of HPV-related cervical cells, and it will enable us to assess the feasibility of using these agents.

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baarmoederhalskanker, HPV virus, groene thee