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Klik hier voor artikelen met groene thee in de titel op onze website.

13 september 2025: Bron: Frontiers in public health 2025 Feb 25;13:1531953

Langdurig groene thee gebruik (20 jaar) vermindert het risico op het krijgen van een depressie doordat ontstekingen verminderden en er beter werd geslapen. Bovendien gaf het groene thee drinken ook een positief effect op verlaging van de BMI en de testosteronspiegel te verhogen bij mannen van middelbare leeftijd en oudere volwassenen. Aldus de resultaten uit een gerandomiseerde studie met totaal 280 deelnemers, waarvan 150 deelnemers groene thee drinkers vs 130 controlegroep van geen groene thee drinkers. De onderzoekers volgden de deelnemers 20 jaar lang via bloedafnames en vragenlijsten enz. Een groene thee drinker wordt gedefinieerd als drinker van dagelijks minimaal 1 kop groene thee of 6 dagen per week.

Een stukje vertaalt uit de introductie geeft meer zicht op waarom de onderzoekers deze studie hebben opgezet:

Depressie is een veelvoorkomende psychische stoornis die het sociale functioneren en de kwaliteit van leven van mensen ernstig beïnvloedt. Meer dan de helft van alle zelfmoorden is gerelateerd aan depressie. De Wereldgezondheidsorganisatie categoriseerde ernstige depressie in 2008 als de derde belangrijkste oorzaak van wereldwijde ziektelast en voorspelde dat het in 2030 de eerste zou worden,(1, 2).
Volwassenen van middelbare leeftijd en ouderen zijn vatbaarder voor depressie omdat ze vaker te maken krijgen met ziekten en neurologische veranderingen die verband houden met veroudering. Van de volwassenen van 55 jaar en ouder lijdt 2% aan een ernstige depressie en 10-15% van de ouderen vertoont significante depressieve symptomen. Bovendien neemt de prevalentie van depressie toe met de leeftijd (3), waarbij vrouwen een hoger risico lopen, maar mannen ernstigere gevolgen ervaren (4), met een significant hoger risico op zelfmoord dan vrouwen (5).

Er is steeds meer aandacht voor hoe het risico op depressie bij mannen van middelbare leeftijd en ouderen kan worden verminderd en dergelijke ernstige gevolgen kunnen worden vermeden. Onderzoek suggereert dat fysieke activiteit de cognitieve functie van volwassenen van middelbare leeftijd en ouderen effectief kan verbeteren (6) en het risico op depressie via verschillende wegen kan verminderen (7, 8).
In de afgelopen twintig jaar is de hoeveelheid fysieke activiteit onder ouderen in China, met name mannen, echter aanzienlijk afgenomen, met meer tijd besteed aan activiteiten zoals tv-kijken en mahjong spelen (9). Deze trend vormt een risico voor het ontstaan en de progressie van depressie. Daarom is er dringend behoefte aan het identificeren en implementeren van aanvullende strategieën om het risico op depressie bij deze bevolkingsgroep te verlagen. Een dergelijke strategie is de consumptie van groene thee, een veelgebruikte, betaalbare en gezonde drank, die vooral populair is onder mannen van middelbare leeftijd en ouderen in China (10, 11). De gezondheidsvoordelen ervan hebben veel aandacht gekregen.

Groene thee bevat een overvloed aan natuurlijke bioactieve stoffen waarvan is aangetoond dat ze de fysieke functie verbeteren en de stofwisseling bevorderen (12–15). Er is echter nog steeds geen consensus over deze conclusie onder onderzoekers (19, 20), mogelijk als gevolg van significante verschillen in de waargenomen indicatoren [zoals de hoeveelheid, concentratie en frequentie van groene theeconsumptie (21–23)].
In de afgelopen jaren hebben enkele dierstudies gesuggereerd dat de effecten van bioactieve stoffen in thee op de endocriene functie beïnvloed kunnen worden door de duur van het gebruik (24, 25).

Er zijn echter weinig studies gericht op de langetermijneffecten van het drinken van thee op het menselijk lichaam. Als dagelijkse drank kan de impact van de langetermijnaccumulatie op het lichaam niet worden genegeerd. Daarom is deze studie er primair op gericht om de effecten van langdurig groene theegebruik op de niveaus van depressie, hormonen en hersenstructuur bij mannen van middelbare leeftijd en oudere volwassenen te onderzoeken door middel van een vergelijkende studie.

De resultaten zoals in het studierapport zijn vermeld:

De resultaten duiden op significante correlaties tussen de systemische immuunontstekingsindex (SII) (p < 0,01), hartslag (p < 0,01), slaapduur (p < 0,01), ernst van de slapeloosheid (p < 0,01) en sociale steun (p < 0,05) en de ernst van de depressie. Vervolgens toonde geordende logistieke regressieanalyse aan dat de ernst van de depressie in de groep die langdurig thee had gedronken significant lager was (p = 0,017). (De gedetailleerde inhoud is te vinden in Figures 1, 2).

Hier figuur 1:

De resultaten toonden aan dat er significante indirecte effecten zijn van SII en slapeloosheid op de relatie tussen theedrinken en de mate van depressie (Table 3; Figure 3). Het totale indirecte effect van theedrinken op de mate van depressie was 0,103 (SE = 0,035, 95% BI [0,041, 0,180], p = 0,002), goed voor 51,6% van het totale effect. Aangezien het directe effect niet significant was (0,089, SE = 0,057, 95% BI [-0,016, 0,189], p = 0,094), zou theedrinken de mate van depressie kunnen beïnvloeden, voornamelijk via de mediërende variabelen, waaronder SII en de mate van slapeloosheid. De mediërende effecten van SII en de mate van slapeloosheid waren beide significant en bedroegen 0,019 (SE=0,014, 95% CI [0,001, 0,059], p=0,041) en 0,084 (SE=0,032, 95% CI [0,032, 0,157], p=0,003), respectievelijk goed voor 9,4 en 42,2% van het totale effect.

Het volledige studierapport is gratis in te zien of te downloaden. Klik daarvoor op de titel van het abstract:

. 2025 Feb 25;13:1531953. doi: 10.3389/fpubh.2025.1531953

Long-term consumption of green tea protects the mental health of middle-aged and older adult men by improving inflammation levels

Zhenyu Wan ^1,^†, Qirong Wan ^1,^†, Xucong Qin ^1,^†, Gaohua Wang ^1,^*, Hong Lin ², Yong Jin ², Bing Wan ³, Linfeng Ai ³, Juan Wei ⁴

PMCID: PMC11893420 PMID: 40071113

Abstract

Background

Middle-aged and older adult men are at a heightened risk of depression. Green tea, as a popular beverage, has drawn widespread attention for its health benefits. However, there remains controversy over the effects of green tea on combating depression and regulating hormones.

Objective

This study aimed to investigate the effects of long-term green tea consumption on depression levels, hormones, and brain structure in, middle-aged and older adult men.

Methods

A total of 280 volunteers participated in the study, divided into a tea-drinking group and a control group. Basic demographic information and biological marker data, as well as MRI data from some of the volunteers, were collected. A controlled study was conducted to explore the effects of long-term tea drinking on them.

Results

BMI (p = 0.002), depression level (p = 0.003), insomnia severity (p = 0.008), and systemic inflammation index (p = 0.009) were significantly lower in the tea drinking group, and their testosterone levels were significantly higher than those in the control group (p = 0.001). Moreover, GM volume in the right precuneus in the control group was significantly reduced compared with that in the tea drinking group.

Conclusion

Long-term tea consumption helps reduce BMI and increase testosterone levels in middle-aged and older adult men, and it can also reduce their risk of depression by lowering inflammation and improving sleep quality. Additionally, long-term tea consumption may have the potential to delay brain aging in middle-aged and older adult men.

Funding Statement

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was funded by the National Science and Technology Innovation 2030-Major program of “Brain Science and Brain-Like Research”, grant number 2021ZD0200701.

Footnotes

¹ https://surfer.nmr.mgh.harvard.edu/

Data availability statement

The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.

Ethics statement

The studies involving humans were approved by Second Xiangya Hospital, Central South University. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin.

Author contributions

ZW: Conceptualization, Formal analysis, Investigation, Writing – original draft. QW: Investigation, Project administration, Resources, Writing – review & editing. XQ: Conceptualization, Formal analysis, Investigation, Writing – review & editing. GW: Writing – review & editing. HL: Investigation, Resources, Writing – review & editing. YJ: Investigation, Resources, Writing – review & editing. BW: Investigation, Resources, Writing – review & editing. LA: Investigation, Resources, Writing – review & editing. JW: Investigation, Resources, Writing – review & editing.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The authors declare that no Gen AI was used in the creation of this manuscript.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

1.Smith K. Mental health: a world of depression. Nature. (2014) 515:180–1. doi: 10.1038/515180a [DOI] [PubMed] [Google Scholar]
2.Malhi GS, Mann JJ. Depression. Lancet. (2018) 392:2299–312. doi: 10.1016/S0140-6736(18)31948-2 [DOI] [PubMed] [Google Scholar]
3.Kok RM, Reynolds CF., 3rd. Management of Depression in older adults: a review. JAMA. (2017) 317:2114–22. doi: 10.1001/jama.2017.5706 [DOI] [PubMed] [Google Scholar]
4.Zhou F, He S, Shuai J, Deng Z, Wang Q, Yan Y. Social determinants of health and gender differences in depression among adults: a cohort study. Psychiatry Res. (2023) 329:115548. doi: 10.1016/j.psychres.2023.115548, PMID: [DOI] [PubMed] [Google Scholar]
5.Beghi M, Butera E, Cerri CG, Cornaggia CM, Febbo F, Mollica A, et al. Suicidal behaviour in older age: a systematic review of risk factors associated to suicide attempts and completed suicides. Neurosci Biobehav Rev. (2021) 127:193–211. doi: 10.1016/j.neubiorev.2021.04.011 [DOI] [PubMed] [Google Scholar]
6.Zhu CE, Zhou L, Zhang X. Effects of leisure activities on the cognitive ability of older adults: a latent variable growth model analysis. Front Psychol. (2022) 13:838878. doi: 10.3389/fpsyg.2022.838878, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
7.Gao Y, Jia Z, Zhao L, Han S. The effect of activity participation in middle-aged and older people on the trajectory of depression in later life: National Cohort Study. JMIR Public Health Surveill. (2023) 9:e44682. doi: 10.2196/44682, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
8.Zhang S, Xiang K, Li S, Pan HF. Physical activity and depression in older adults: the knowns and unknowns. Psychiatry Res. (2021) 297:113738. doi: 10.1016/j.psychres.2021.113738 [DOI] [PubMed] [Google Scholar]
9.Feng Q, Fong JH, Zhang W, Liu C, Chen H. Leisure activity engagement among the oldest old in China, 1998–2018. Am J Public Health. (2020) 110:1535–7. doi: 10.2105/AJPH.2020.305798, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
10.Tian T, Lv J, Jin G, Yu C, Guo Y, Bian Z, et al. Tea consumption and risk of stroke in Chinese adults: a prospective cohort study of 0.5 million men and women. Am J Clin Nutr. (2020) 111:197–206. doi: 10.1093/ajcn/nqz274, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
11.Chen ZM, Lin Z. Tea and human health: biomedical functions of tea active components and current issues. J Zhejiang Univ Sci B. (2015) 16:87–102. doi: 10.1631/jzus.B1500001, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
12.Yang X, Dai H, Deng R, Zhang Z, Quan Y, Giri M, et al. Association between tea consumption and prevention of coronary artery disease: a systematic review and dose-response meta-analysis. Front Nutr. (2022) 9:1021405. doi: 10.3389/fnut.2022.1021405, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
13.Pang J, Zhang Z, Zheng TZ, Bassig BA, Mao C, Liu X, et al. Green tea consumption and risk of cardiovascular and ischemic related diseases: a meta-analysis. Int J Cardiol. (2016) 202:967–74. doi: 10.1016/j.ijcard.2014.12.176, PMID: [DOI] [PubMed] [Google Scholar]
14.Wang ZY, Khan WA, Bickers DR, Mukhtar H. Protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice by green tea polyphenols. Carcinogenesis. (1989) 10:411–5. doi: 10.1093/carcin/10.2.411, PMID: [DOI] [PubMed] [Google Scholar]
15.Dinh TC, Thi Phuong TN, Minh LB, Minh Thuc VT, Bac ND, van Tien N, et al. The effects of green tea on lipid metabolism and its potential applications for obesity and related metabolic disorders – an existing update. Diabetes Metab Syndr. (2019) 13:1667–73. doi: 10.1016/j.dsx.2019.03.021, PMID: [DOI] [PubMed] [Google Scholar]
16.Miki T, Kochi T, Kuwahara K, Eguchi M, Kurotani K, Tsuruoka H, et al. Dietary patterns derived by reduced rank regression (RRR) and depressive symptoms in Japanese employees: the Furukawa nutrition and health study. Psychiatry Res. (2015) 229:214–9. doi: 10.1016/j.psychres.2015.07.033 [DOI] [PubMed] [Google Scholar]
17.Li FD, He F, Ye XJ, Shen W, Wu YP, Zhai YJ, et al. Tea consumption is inversely associated with depressive symptoms in the elderly: a cross-sectional study in eastern China. J Affect Disord. (2016) 199:157–62. doi: 10.1016/j.jad.2016.04.005, PMID: [DOI] [PubMed] [Google Scholar]
18.Dong X, Yang C, Cao S, Gan Y, Sun H, Gong Y, et al. Tea consumption and the risk of depression: a meta-analysis of observational studies. Aust N Z J Psychiatry. (2015) 49:334–45. doi: 10.1177/0004867414567759, PMID: [DOI] [PubMed] [Google Scholar]
19.Nanri A, Eguchi M, Kochi T, Kabe I, Mizoue T. Green tea consumption and depressive symptoms among Japanese workers: the Furukawa nutrition and health study. Nutrients. (2021) 14:167. doi: 10.3390/nu14010167, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
20.Kimura Y, Suga H, Kobayashi S, Sasaki S, Three-Generation Study of Women on Diets and Health Study Group . Intake of coffee associated with decreased depressive symptoms among elderly Japanese women: a multi-center cross-sectional study. J Epidemiol. (2020) 30:338–44. doi: 10.2188/jea.JE20190010, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
21.Wei C, Zhang J, Chen N, Xu Z, Tang H. Does frequent tea consumption provide any benefit to cognitive function in older adults? Evidence from a national survey from China in 2018. Front Public Health. (2023) 11:1269675. doi: 10.3389/fpubh.2023.1269675, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
22.Yao Y, Chen H, Chen L, Ju SY, Yang H, Zeng Y, et al. Type of tea consumption and depressive symptoms in Chinese older adults. BMC Geriatr. (2021) 21:331. doi: 10.1186/s12877-021-02203-z, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
23.Chen X, Lu W, Zheng Y, Gu K, Chen Z, Zheng W, et al. Exercise, tea consumption, and depression among breast cancer survivors. J Clin Oncol. (2010) 28:991–8. doi: 10.1200/JCO.2009.23.0565, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
24.Monteiro R, Assunção M, Andrade JP, Neves D, Calhau C, Azevedo I. Chronic green tea consumption decreases body mass, induces aromatase expression, and changes proliferation and apoptosis in adult male rat adipose tissue. J Nutr. (2008) 138:2156–63. doi: 10.1093/jn/138.11.2156 [DOI] [PubMed] [Google Scholar]
25.Shen CL, Wang P, Guerrieri J, Yeh JK, Wang JS. Protective effect of green tea polyphenols on bone loss in middle-aged female rats. Osteoporos Int. (2008) 19:979–90. doi: 10.1007/s00198-007-0527-5, PMID: [DOI] [PubMed] [Google Scholar]
26.Chou K-L. Assessing Chinese adolescents’ social support: the multidimensional scale of perceived social support. Personal Individ Differ. (2000) 28:299–307. doi: 10.1016/S0191-8869(99)00098-7 [DOI] [Google Scholar]
27.Thorndike FP, Ritterband LM, Saylor DK, Magee JC, Gonder-Frederick LA, Morin CM. Validation of the insomnia severity index as a web-based measure. Behav Sleep Med. (2011) 9:216–23. doi: 10.1080/15402002.2011.606766, PMID: [DOI] [PubMed] [Google Scholar]
28.Bastien CH, Vallières A, Morin CM. Validation of the insomnia severity index as an outcome measure for insomnia research. Sleep Med. (2001) 2:297–307. doi: 10.1016/s1389-9457(00)00065-4, PMID: [DOI] [PubMed] [Google Scholar]
29.Mazza MG, Palladini M, De Lorenzo R, Magnaghi C, Poletti S, Furlan R, et al. Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up. Brain Behav Immun. (2021) 94:138–47. doi: 10.1016/j.bbi.2021.02.021, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
30.Tian T, Lu J, Zhao W, Wang Z, Xu H, Ding Y, et al. Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population. Cancer Med. (2022) 11:2482–91. doi: 10.1002/cam4.4606 [DOI] [PMC free article] [PubMed] [Google Scholar]
31.Zhang F, Niu M, Wang L, Liu Y, Shi L, Cao J, et al. Systemic-immune-inflammation index as a promising biomarker for predicting perioperative ischemic stroke in older patients who underwent non-cardiac surgery. Front Aging Neurosci. (2022) 14:865244. doi: 10.3389/fnagi.2022.865244, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
32.Negeri ZF, Levis B, Sun Y, He C, Krishnan A, Wu Y, et al. Accuracy of the patient health Questionnaire-9 for screening to detect major depression: updated systematic review and individual participant data meta-analysis. BMJ. (2021) 375:n2183. doi: 10.1136/bmj.n2183, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
33.Reuter M, Rosas HD, Fischl B. Highly accurate inverse consistent registration: a robust approach. NeuroImage. (2010) 53:1181–96. doi: 10.1016/j.neuroimage.2010.07.020, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
34.Preacher KJ, Hayes AF. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods. (2008) 40:879–91. doi: 10.3758/brm.40.3.879, PMID: [DOI] [PubMed] [Google Scholar]
35.Singh BN, Shankar S, Srivastava RK. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol. (2011) 82:1807–21. doi: 10.1016/j.bcp.2011.07.093, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
36.Kim J, Kim J. Green tea, coffee, and caffeine consumption are inversely associated with self-report lifetime depression in the Korean population. Nutrients. (2018) 10:1201. doi: 10.3390/nu10091201, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
37.Shen W, Pan Y, Jin B, Zhang Z, You T, Qu Y, et al. Effects of tea consumption on anthropometric parameters, metabolic indexes and hormone levels of women with polycystic ovarian syndrome: a systematic review and Meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne). (2021) 12:736867. doi: 10.3389/fendo.2021.736867, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
38.Alufer L, Tsaban G, Rinott E, Kaplan A, Meir AY, Zelicha H, et al. Long-term green-Mediterranean diet may favor fasting morning cortisol stress hormone; the DIRECT-PLUS clinical trial. Front Endocrinol (Lausanne). (2023) 14:1243910. doi: 10.3389/fendo.2023.1243910, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
39.Figueiroa MS, César Vieira JS, Leite DS, Filho RC, Ferreira F, Gouveia PS, et al. Green tea polyphenols inhibit testosterone production in rat Leydig cells. Asian J Androl. (2009) 11:362–70. doi: 10.1038/aja.2009.2, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
40.Yu PL, Pu HF, Chen SY, Wang SW, Wang PS. Effects of catechin, epicatechin and epigallocatechin gallate on testosterone production in rat leydig cells. J Cell Biochem. (2010) 110:333–42. doi: 10.1002/jcb.22541 [DOI] [PubMed] [Google Scholar]
41.Feng L, Yan Z, Sun B, Cai C, Jiang H, Kua EH, et al. Tea consumption and depressive symptoms in older people in rural China. J Am Geriatr Soc. (2013) 61:1943–7. doi: 10.1111/jgs.12496, PMID: [DOI] [PubMed] [Google Scholar]
42.Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, Cauley JA, et al. Testosterone trials investigators. Effects of testosterone treatment in older men. N Engl J Med. (2016) 374:611–24. doi: 10.1056/NEJMoa1506119 [DOI] [PMC free article] [PubMed] [Google Scholar]
43.Kotsopoulos J, Eliassen AH, Missmer SA, Hankinson SE, Tworoger SS. Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women. Cancer. (2009) 115:2765–74. doi: 10.1002/cncr.24328, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
44.Schliep KC, Schisterman EF, Mumford SL, Pollack AZ, Zhang C, Ye A, et al. Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle study. Am J Clin Nutr. (2012) 95:488–97. doi: 10.3945/ajcn.111.021287, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
45.Nagata C, Kabuto M, Shimizu H. Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. Nutr Cancer. (1998) 30:21–4. doi: 10.1080/01635589809514635, PMID: [DOI] [PubMed] [Google Scholar]
46.van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab. (2000) 85:3276–82. doi: 10.1210/jcem.85.9.6825, PMID: [DOI] [PubMed] [Google Scholar]
47.Chandra AK, De N. Goitrogenic/antithyroidal potential of green tea extract in relation to catechin in rats. Food Chem Toxicol. (2010) 48:2304–11. doi: 10.1016/j.fct.2010.05.064, PMID: [DOI] [PubMed] [Google Scholar]
48.Chandra AK, De N. Catechin induced modulation in the activities of thyroid hormone synthesizing enzymes leading to hypothyroidism. Mol Cell Biochem. (2013) 374:37–48. doi: 10.1007/s11010-012-1503-8, PMID: [DOI] [PubMed] [Google Scholar]
49.Sakamoto Y, Mikuriya H, Tayama K, Takahashi H, Nagasawa A, Yano N, et al. Goitrogenic effects of green tea extract catechins by dietary administration in rats. Arch Toxicol. (2001) 75:591–6. doi: 10.1007/s00204-001-0286-6 [DOI] [PubMed] [Google Scholar]
50.Satoh K, Sakamoto Y, Ogata A, Nagai F, Mikuriya H, Numazawa M, et al. Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. Food Chem Toxicol. (2002) 40:925–33. doi: 10.1016/s0278-6915(02)00066-2, PMID: [DOI] [PubMed] [Google Scholar]
51.Baba Y, Takihara T, Okamura N. Theanine maintains sleep quality in healthy young women by suppressing the increase in caffeine-induced wakefulness after sleep onset. Food Funct. (2023) 14:7109–16. doi: 10.1039/d3fo01247f, PMID: [DOI] [PubMed] [Google Scholar]
52.Watson EJ, Banks S, Coates AM, Kohler MJ. The relationship between caffeine, sleep, and behavior in children. J Clin Sleep Med. (2017) 13:533–43. doi: 10.5664/jcsm.6536, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
53.Thakre TP, Deoras K, Griffin C, Vemana A, Podmore P, Krishna J. Caffeine awareness in children: insights from a pilot study. J Clin Sleep Med. (2015) 11:741–6. doi: 10.5664/jcsm.4848. PMID: 25845895, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
54.Ng TP, Gao Q, Gwee X, Chua DQL. Tea consumption and depression from follow up in the Singapore longitudinal ageing study. J Nutr Health Aging. (2021) 25:295–301. doi: 10.1007/s12603-020-1526-x, PMID: [DOI] [PubMed] [Google Scholar]
55.de Feijter M, Kocevska D, Ikram MA, Luik AI. The bidirectional association of 24-h activity rhythms and sleep with depressive symptoms in middle-aged and elderly persons. Psychol Med. (2023) 53:1418–25. doi: 10.1017/S003329172100297X, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
56.Rao TP, Ozeki M, Juneja LR. In search of a safe natural sleep aid. J Am Coll Nutr. (2015) 34:436–47. doi: 10.1080/07315724.2014.926153 [DOI] [PubMed] [Google Scholar]
57.Luvián-Morales J, Varela-Castillo FO, Flores-Cisneros L, Cetina-Pérez L, Castro-Eguiluz D. Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review. Crit Rev Food Sci Nutr. (2022) 62:4371–92. doi: 10.1080/10408398.2021.1875189, PMID: [DOI] [PubMed] [Google Scholar]
58.Ntamo Y, Jack B, Ziqubu K, Mazibuko-Mbeje SE, Nkambule BB, Nyambuya TM, et al. Epigallocatechin gallate as a nutraceutical to potentially target the metabolic syndrome: novel insights into therapeutic effects beyond its antioxidant and anti-inflammatory properties. Crit Rev Food Sci Nutr. (2024) 64:87–109. doi: 10.1080/10408398.2022.2104805 [DOI] [PubMed] [Google Scholar]
59.Arnold N, Koenig W. Infection, inflammation, and cardiovascular risk: are we underestimating an old disease? Eur Heart J. (2024) 45:1521–3. doi: 10.1093/eurheartj/ehae104, PMID: [DOI] [PubMed] [Google Scholar]
60.Li C, Ke B, Chen J, Xiao Y, Wang S, Jiang R, et al. Systemic inflammation and risk of Parkinson’s disease: a prospective cohort study and genetic analysis. Brain Behav Immun. (2024) 117:447–55. doi: 10.1016/j.bbi.2024.02.013, PMID: [DOI] [PubMed] [Google Scholar]
61.Ashton JJ, Satsangi J, Uhlig HH. Intestinal inflammation and Extraintestinal disease: understanding dynamic risk. Gastroenterology. (2024) 167:205–8. doi: 10.1053/j.gastro.2024.03.040, PMID: [DOI] [PubMed] [Google Scholar]
62.Yang W, Liu J. Regarding the role of systemic immune-inflammation index on the risk of chronic kidney disease. Int J Surg. (2024) 110:2467–8. doi: 10.1097/JS9.0000000000001097, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
63.Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron. (2020) 107:234–56. doi: 10.1016/j.neuron.2020.06.002, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
64.Stazi M, Lehmann S, Sakib MS, Pena-Centeno T, Büschgens L, Fischer A, et al. Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis. Cell Mol Life Sci. (2021) 79:55. doi: 10.1007/s00018-021-04062-8, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
65.Xu H, Fiocco AJ, Liu X, Wang T, Li G, Xiao S, et al. Association between tea consumption and cognitive function in cognitively healthy older adults and older adults with mild cognitive impairment. Gen Psychiatr. (2021) 34:e100512. doi: 10.1136/gpsych-2021-100512, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
66.Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, et al. The effect of a high-polyphenol Mediterranean diet (green-MED) combined with physical activity on age-related brain atrophy: the dietary intervention randomized controlled trial polyphenols unprocessed study (DIRECT PLUS). Am J Clin Nutr. (2022) 115:1270–81. doi: 10.1093/ajcn/nqac001 [DOI] [PMC free article] [PubMed] [Google Scholar]
67.Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. (2010) 21:187–221. doi: 10.1515/revneuro.2010.21.3.187, PMID: [DOI] [PubMed] [Google Scholar]
68.Epstein R, Kanwisher N. A cortical representation of the local visual environment. Nature. (1998) 392:598–601. doi: 10.1038/33402 [DOI] [PubMed] [Google Scholar]
69.Grill-Spector K, Malach R. The human visual cortex. Annu Rev Neurosci. (2004) 27:649–77. doi: 10.1146/annurev.neuro.27.070203.144220 [DOI] [PubMed] [Google Scholar]
70.Ortiz-López L, Márquez-Valadez B, Gómez-Sánchez A, Silva-Lucero MD, Torres-Pérez M, Téllez-Ballesteros RI, et al. Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro. Neuroscience. (2016) 322:208–20. doi: 10.1016/j.neuroscience.2016.02.040, PMID: [DOI] [PubMed] [Google Scholar]
71.Salameh A, Einenkel A, Kühne L, Grassl M, von Salisch S, Kiefer P, et al. Hippocampal neuroprotection by minocycline and Epigallo-Catechin-3-Gallate against cardiopulmonary bypass-associated injury. Brain Pathol. (2015) 25:733–42. doi: 10.1111/bpa.12242, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]
72.Hunter SK, Senefeld JW. Sex differences in human performance. J Physiol. (2024) 602:4129–56. doi: 10.1113/JP284198, PMID: [DOI] [PubMed] [Google Scholar]
73.Wan Z, Qin X, Tian Y, Ouyang F, Wang G, Wan Q. Long-term consumption of green tea can reduce the degree of depression in postmenopausal women by increasing estradiol. Nutrients. (2023) 15:4514. doi: 10.3390/nu15214514, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Data Availability Statement

The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.

groene thee, mannen van 55-plus leeftijd, gerandomiseerde studie, risico op depressie, BMI, slaapkwaliteit, chronische ontstekingen