Zie ook literatuurlijsten van niet-toxische middelen, voeding en weinig belastende behandelingen bij specifiek verschillende vormen van kanker en operaties, chemo en bestraling van arts-bioloog drs. Engelbert Valstar.

3 november 2020: Bron: British Journal of Clinical Pharmalogy october 2020.

Voor vrouwen met borstkanker, darmkanker of een melanoom heeft het nemen van zogeheten lipidenverlagende medicijnen (LLM) (statines bv) een positieve invloed op de mediane overall overleving. 

De afname in het risico op overlijden was meer uitgesproken voor vrouwen die meer lipofiele dan hydrofiele statines gebruikten bij alle drie de vormen van kanker. Bij borstkanker en darmkanker was het verschil statistisch significant, bij een melanoom net niet, maar wel een verschil in risico op overlijden.

Zie ook dit studieverslag uit 2016: Nieuwe lipidenverlagende middelen – een doorbraak in cholesterolbehandeling?

Uit het studierapport vertaald:

Wat is er al bekend over dit onderwerp:

  • Preklinisch bewijs ondersteunt lipidenverlagende medicijnen, voornamelijk statines hebben antikanker eigenschappen.
  • Niet overtuigende observationele bevindingen van dit medicijn over het overlevingsvoordeel van kanker vereisen meer bewijs voor het herbestemmen van dit medicijn als adjuvante kankertherapie.

Wat deze studie toevoegt:

  • Therapietrouw aan lipidenverlagende medicatie is omgekeerd evenredig met een afname van de kankerspecifieke sterfte bij borstkanker, darmkanker en melanoom.
  • Lipofiele statines laten een grotere afname van kankerspecifiek overlijden zien.
  • De associatie met langere overall overleving wordt niet veranderd door hormoontherapie bij borstkanker.

Het volledige studierapport is gratis in te zien, klik op de titel, met hier het abstract.

Does adherence to lipid‐lowering medications improve cancer survival? A nationwide study of breast and colorectal cancer, and melanoma

First published: 20 October 2020

Funding information: National Health and Medical Research Council of Australia, Grant/Award Number: (GNT 1073898)



Inconclusive findings of lipid‐lowering medications (LLMs) on cancer survival benefit require more evidence. We tested the hypothesis that adherence to this drug is associated with reduced cancer‐specific mortality in a homogeneous population who had used this drug before cancer diagnosis.


The Australian Cancer Database was linked to the Pharmaceutical Benefits Scheme database, and to the National Death Index (up to 2015). Medication adherence was calculated by proportion of days covered. Cox regression models with time‐varying covariates were used to derive multivariable‐adjusted cause‐specific hazard ratio (HR) and 95% confidence interval (CI) for the associations between adherence to LLMs, statins, lipophilic, and hydrophilic statins and cancer‐specific mortality.


From 2003 to 2013, 3 separate cohorts of 20 046, 11 719 and 6430 female patients with newly diagnosed breast, colorectal cancer, and melanoma respectively were identified. The 1‐year adherence was similar at 1‐year prediagnosis in the 3 cohorts, on average 82%. Each 10% increase in 1‐year adherence to LLMs was inversely associated with cancer‐specific mortality among women with breast cancer (fully adjusted HR = 0.92, 95% CI 0.91–0.93), colorectal cancer (fully adjusted HR = 0.92, 95% CI 0.91–0.93), or melanoma (fully adjusted HR = 0.97, 95% CI 0.94–1.00). The reductions in cancer‐specific mortality were more pronounced for women who adhered to lipophilic than hydrophilic statins in all 3 cancers albeit not statistically significant for melanoma.


Among LLM users, adherence to this drug is associated with a decrease in cancer‐specific mortality. If confirmed, LLMs could be considered as an adjuvant cancer therapy to improve prognosis in cancer survivors.

What is already known about this subject

  • Preclinical evidence supports lipid‐lowering medications primarily statins have anticancer properties.
  • Inconclusive observational findings of this drug on cancer survival benefit require more evidence for repurposing this drug as adjuvant cancer therapy.

What this study adds

  • Adherence to lipid‐lowering medication is inversely associated with decline in cancer‐specific mortality in breast and colorectal cancer, and melanoma.
  • Lipophilic statins show greater reductions in cancer‐specific mortality.
  • The inverse association is not altered by receiving endocrine therapy in breast cancer.
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