20 december 2016: Bron: World J Gastrointest Oncol. 2015 Apr 15; 7(4): 17–29.

Wanneer kankerpatiënten in een gevorderd stadium van hun ziekte verkeren krijgen ze bijna altijd te maken met sterke vermagering, ook wel cahexie genoemd. Ook chemokuren en nieuwe medicijn combinaties binnen personalised medicine veroorzaken vaak sterke vermagering. Uit de literatuur blijkt dat 20 procent ook vroegtijdig overlijdt mede door die sterke vermagering. De laatste jaren echter zijn er wel behandelingen gevonden die die vermagering tegengaan. Met als effect dat de kwaliteit van leven verbetert en het ook invloed heeft op de overall overleving.

In de literatuurlijsten van arts-bioloog drs. Engelbert Valstar staan ook per kankersoort of naast chemo studies vermeld van niet-toxische voedingsstoffen die vermagering tegengaan. Maar ook in de reguliere oncologie zijn er inmiddels wel synthethische stoffen / medicijnen die die vermagering kunnen tegengaan.

In dit studierapport: Cancer cachexia, mechanism and treatment worden een aantal behandelingen / middelen tegen cahexie beschreven. Zie o.a. de groen gemaakte sleutelwoorden.

Tekst gaat verder onder foto.

cachexie

Bron foto: Medical facts: 

http://www.medicalfacts.nl/2013/08/28/maastrichts-onderzoek-biedt-perspectief-voor-longkankerpatienten-met-spiermassaverlies/

Combination therapy with diet modification and/or exercise has been added to novel pharmaceutical agents, such as Megestrol acetate, medroxyprogesterone, ghrelin, omega-3-fatty acid among others. These agents are reported to have improved survival rates as well as quality of life. In this review, we will discuss the emerging understanding of the mechanisms of cancer cachexia, the current treatment options including multidisciplinary combination therapies, as well an update on new and ongoing clinical trials.

World J Gastrointest Oncol. 2015 Apr 15; 7(4): 17–29.
Published online 2015 Apr 15. doi:  10.4251/wjgo.v7.i4.17
PMCID: PMC4398892

Cancer cachexia, mechanism and treatment

Abstract

It is estimated that half of all patients with cancer eventually develop a syndrome of cachexia, with anorexia and a progressive loss of adipose tissue and skeletal muscle mass. Cancer cachexia is characterized by systemic inflammation, negative protein and energy balance, and an involuntary loss of lean body mass. It is an insidious syndrome that not only has a dramatic impact on patient quality of life, but also is associated with poor responses to chemotherapy and decreased survival. Cachexia is still largely an underestimated and untreated condition, despite the fact that multiple mechanisms are reported to be involved in its development, with a number of cytokines postulated to play a role in the etiology of the persistent catabolic state. Existing therapies for cachexia, including orexigenic appetite stimulants, focus on palliation of symptoms and reduction of the distress of patients and families rather than prolongation of life. Recent therapies for the cachectic syndrome involve a multidisciplinary approach. Combination therapy with diet modification and/or exercise has been added to novel pharmaceutical agents, such as Megestrol acetate, medroxyprogesterone, ghrelin, omega-3-fatty acid among others. These agents are reported to have improved survival rates as well as quality of life. In this review, we will discuss the emerging understanding of the mechanisms of cancer cachexia, the current treatment options including multidisciplinary combination therapies, as well an update on new and ongoing clinical trials.

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