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27 september 2022: Bron: European Urology Oncology Published:August 19, 2022

Veel koffie drinken blijkt langere prostaatkanker specifieke overleving te geven voor bepaalde groepen mannen met prostaatkanker, waaronder die met het CYP1A2 AA-genotype. Dat blijkt uit een studie die op 19 augustus online is gepubliceerd in European Urology Oncology.

Justin R. Gregg, MD, van het MD Anderson Cancer Center van de Universiteit van Texas in Houston, en collega's onderzochten de associaties tussen koffie inname, het genotype van het cafeïnemetabolisme en overleving met behulp van gegevens uit de PRACTICAL Consortium-database voor 5.727 mannen met prostaatkanker.

De onderzoekers ontdekten dat, hoewel de resultaten niet statistisch significant waren, dat een hoge koffie inname geassocieerd leek te zijn met langere prostaatkanker specifieke overleving en betere algehele overleving.
Hoge koffie inname was geassocieerd met langere prostaatkanker specifieke overleving bij mannen met lokale prostaatkanker, met vergelijkbare, maar niet statistisch significante resultaten bij mensen met gevorderde prostaatkanker.
Bij mannen met het CYP1A2 AA-genotype was een hoge koffie inname geassocieerd met een wel statistisch significant langere prostaatkanker specifieke overleving; er werden geen associaties gezien voor mannen met het AC/CC-genotype.

Het volledige studierapport is gratis in te zien of te downloaden. Klik op de titel van het abstract:

Coffee Intake, Caffeine Metabolism Genotype, and Survival Among Men with Prostate Cancer

Published:August 19, 2022DOI:



Coffee intake may lower prostate cancer risk and progression, but postdiagnosis outcomes by caffeine metabolism genotype are not well characterized.


To evaluate associations between coffee intake, caffeine metabolism genotype, and survival in a large, multicenter study of men with prostate cancer.

Design, setting, and participants

Data from The PRACTICAL Consortium database for 5727 men with prostate cancer from seven US, Australian, and European studies were included. The cases included had data available for the CYP1A2 −163C>A rs762551 single-nucleotide variant associated with caffeine metabolism, coffee intake, and >6 mo of follow-up.

Outcome measurements and statistical analysis

Multivariable-adjusted Cox proportional hazards models across pooled patient-level data were used to compare the effect of coffee intake (categorized as low , high, or none/very low) in relation to overall survival (OS) and prostate cancer–specific survival (PCSS), with stratified analyses conducted by clinical disease risk and genotype.

Results and limitations

High coffee intake appeared to be associated with longer PCSS (hazard ratio 0.85, 95% confidence interval 0.68–1.08; p = 0.18) and OS (HR 0.90, 95% CI 0.77–1.07; p = 0.24), although results were not statistically significant. In the group with clinically localized disease, high coffee intake was associated with longer PCSS (HR 0.66, 95% CI 0.44–0.98; p = 0.040), with comparable results for the group with advanced disease (HR 0.92, 95% CI 0.69–1.23; p = 0.6). High coffee intake was associated with longer PCSS among men with the CYP1A2 AA (HR 0.67, 95% CI 0.49–0.93; p = 0.017) but not the AC/CC genotype (p = 0.8); an interaction was detected (p = 0.042). No associations with OS were observed in subgroup analyses (p > 0.05). Limitations include the nominal statistical significance and residual confounding.


Coffee intake was associated with longer PCSS among men with a CYP1A2 −163AA (*1F/*1F) genotype, a finding that will require further replication.

Patient summary

It is likely that coffee intake is associated with longer prostate cancer–specific survival in certain groups, but more research is needed to fully understand which men may benefit and why.


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