16 juni 2010: Clin Cancer Res. 2010 Jun 8.

Psychologische interventie verbetert de lichamelijke en psychische gesteldheid van vrouwen met borstkanker op lange termijn en zorgt ook voor mediaan langere levensduur, blijkt uit gerandomiseerde studie gepresenteerd op ASCO.  De psychologische interventie bleek ook aantoonbaar effect te hebben op het immuunsyteem en natural killers. Ook bleek de groep die psychologische interventie had gekregen na 11 jaar follow-up minder recidieven te krijgen dan de groep vrouwen die de standaard hulp kregen. Hier het abstract van de studie die voor zichzelf spreekt:

Clin Cancer Res. 2010 Jun 8. [Epub ahead of print]

Biobehavioral, Immune, and Health Benefits following Recurrence for Psychological Intervention Participants.

Andersen BL, Thornton LM, Shapiro CL, Farrar WB, Mundy BL, Yang HC, Carson WE 3rd.

Authors' Affiliations: Department of Psychology, and Department of Surgery, Comprehensive Cancer Center and the Solove Research Institute, and Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio.


PURPOSE: A clinical trial was designed to test the hypothesis that a psychological intervention could reduce the risk of cancer recurrence. Newly diagnosed regional breast cancer patients (n = 227) were randomized to the intervention-with-assessment or the assessment-only arm. The intervention had positive psychological, social, immune, and health benefits, and after a median of 11 years the intervention arm was found to have reduced the risk of recurrence (hazard ratio, 0.55; P = 0.034). In follow-up, we hypothesized that the intervention arm might also show longer survival after recurrence. If observed, we then would examine potential biobehavioral mechanisms.

EXPERIMENTAL DESIGN: All patients were followed; 62 recurred. Survival analyses included all 62. Upon recurrence diagnosis, those available for further biobehavioral study were accrued (n = 41, 23 intervention and 18 assessment). For those 41, psychological, social, adherence, health, and immune (natural killer cell cytotoxicity, T-cell proliferation) data were collected at recurrence diagnosis and 4, 8, and 12 months later.

RESULTS: Intent-to-treat analysis revealed reduced risk of death following recurrence for the intervention arm (hazard ratio, 0.41; P = 0.014). Mixed-effects follow-up analyses with biobehavioral data showed that all patients responded with significant psychological distress at recurrence diagnosis, but thereafter only the intervention arm improved (P values < 0.023). Immune indices were significantly higher for the intervention arm at 12 months (P values < 0.017).

CONCLUSIONS: Hazards analyses augment previous findings in showing improved survival for the intervention arm after recurrence. Follow-up analyses showing biobehavioral advantages for the intervention arm contribute to our understanding of how improved survival was achieved. Clin Cancer Res; 16(12); 3270-8. (c)2010 AACR.

PMID: 20530702 [PubMed - as supplied by publisher]

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