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22 januari 2018: Bron: EPMA J. 2015; 6: 25. Published online 2015 Dec 21.

Wanneer vrouwen met intraepithelial neoplasia (CIN) I–II (poliepen), dus met hoog risico op het krijgen van baarmoederhalskanker  dagelijks 200 mg per dag DIM - diindolylmethane nemen naast de gebruikeljke medicijnen dan hebben zij weinig tot geen kans op het krijgen van baarmoederhalskanker want binnen 90 tot 180 dagen verdwenen de CIN i en II afwijkingen) volledig. In vergelijking als de DIM dosis 100 mg. per dag was of een placebo waren de CIN afwijkingen verdwenen bij respectievelijk 90 procent en 61 procent voor placebo. 

Het gebruik van DIM - diindolylmethaan in de vorm van intravaginale zetpillen kan dus effectief zijn bij patiënten met CIN I-II en gaat niet gepaard met klinisch significante bijwerkingen, aldus de onderzoekers. Deze aanpak zou een betere optie kunnen zijn voor jonge vrouwen met CIN I-II, omdat het hun eventuele kinderwensen beschermd en in tact laat. Aldus de onderzoekers. Het is een kleine fase IIA studie maar wel placebo dubbelblind gerandomiseerd dus een kwalitatief goede studie.

DIM 100 mg capsules zijn overall verkrijgbaar maar doe het aub in overleg met een complementair arts.

Uit het studierapport: 

The efficacy of active drug treatment (100 and 200 mg/day) in both treatment groups was significantly higher in comparison with the placebo group, according to the primary efficacy end point (proportion of patients with complete CIN regression after 90–180 days of the study drug treatment).

DIM grafiek bij baarmoederhalskanker preventie

Het is bekend dat baarmoederhalskanker voornamelijk wordt veroorzaakt door het HPV virus dat meestal begint met intraepithelial neoplasia (CIN) afwijkingen (stadium I, II en III)

Uit het studierapport: 

CIN I resolves spontaneously in 50–60 % of cases within 3 years. At the same time, intraepithelial neoplasia develops within 2 years in 15–30 % of women infected with high-risk HPV [6], while about 10–20 % of CIN III cases transform into invasive cervical cancer [7].

In het volledige studierapport: Double-blind randomized placebo-controlled multicenter clinical trial (phase IIa) on diindolylmethane’s efficacy and safety in the treatment of CIN: implications for cervical cancer prevention staat een gedetailleerde beschrijving van de aanpak, maar ook van waarom de onderozkers denken dat DIM zo goed werkt en op welke specifieke genen dit invloed heeft. Maar is voor mij te medisch technisch en is wellciht beter dit met een arts te bespreken. Maar arts-bioloog drs. Engelbert Valstar is over deze studie wel enthousiast.

Hier het abstract van de studie met referentielijst.

the use of diindolylmethane in the form of intravaginal suppositories can be effective in patients with CIN I–II and is not accompanied by clinically significant side effects. This approach could be a better option for young women with CIN I–II as it takes in attention their reproductive plans.

EPMA J. 2015; 6: 25.
Published online 2015 Dec 21. doi:  10.1186/s13167-015-0048-9
PMCID: PMC4685602

Double-blind randomized placebo-controlled multicenter clinical trial (phase IIa) on diindolylmethane’s efficacy and safety in the treatment of CIN: implications for cervical cancer prevention

Levon Ashrafian, Gennady Sukhikh, Vsevolod Kiselev, Mikhail Paltsev, Vadim Drukh, Igor Kuznetsov, Ekaterina Muyzhnek, Inna Apolikhina, and Evgeniya Andrianova

Abstract

BACKGROUND:

The article presents the results of a clinical trial on the efficacy and safety of a novel pharmaceutical composition in the form of vaginal suppositories containing diindolylmethane in the course of cervical intraepithelial neoplasia (CIN) I-II conservative treatment. It offers an attractive drug therapy for more personalized prevention of cervical cancer.

METHODS:

A total of 78 women of reproductive age were included. This was a multicenter, randomized, placebo-controlled, double-blind, parallel-group trial with efficacy determined by histological evaluation of cervical biopsies. The efficacy of active drug treatment (100 and 200 mg/day) in both treatment groups was significantly higher in comparison with the placebo group, according to the primary efficacy end point (proportion of patients with complete CIN regression after 90-180 days of the study drug treatment).

RESULTS:

The efficacies were 100.0 % (confidence interval (CI) 95 %: 82.35-100.00 %), 90.5 % (CI 95 %: 69.62-98.83 %), and 61.1 % (CI 95 %: 35.75-82.70 %), for the high dose, low does, and placebo, respectively. Adverse events in the placebo group were reported in 22 % of patients (CI 95 %: 7.5-43.7 %); in the first treatment group (100 mg/day), adverse events were reported in 40.0 % of patients (CI 95 %: 21.1-61.3 %); in the second treatment group (200 mg/day), adverse events were reported in 42.0 % of patients (CI 95 %: 22.1-63.4 %). The differences in side effects between treatment groups treated with the active drug and placebo were statistically significant. No serious adverse events were reported in any of the groups.

CONCLUSIONS:

Thus, the use of diindolylmethane in the form of intravaginal suppositories can be effective in patients with CIN I-II and is not accompanied by clinically significant side effects. This approach could be a better option for young women with CIN I-II as it takes in attention their reproductive plans.

TRIAL REGISTRATION:

ID: ChiCTR-INR-15007497 (2 December 2015).

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