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23 mei 2020: recent is ook een reviewstudie over hyperthermie bij kanker met solide tumoren gepubliceerd die interessante informatie geeft met veel verwijzingen naar studies. Teveel om hier allemaal te noemen: https://stephensoncancercenter.org/Types-of-Cancer/Pancreatic/NCI-PDQ-Pancreatic/docId/CDR0000742114

23 mei 2020: Bron: Journal of Advanced Research maart 2020

Hyperthermie (electro hyperthermie) samen met een intraveneuze behandeling met hoge dosis vitamine C (IVC)  verbetert de overall overleving met 40 procent van patiënten met vergevorderde voorbehandelde niet-kleincellige longkanker (NSCLC) in vergelijking met beste zorg.

Dit blijkt uit een studie met totaal 97 patiënten met niet-kleincellige longkanker stadium III/IV. Alle patiënten hadden al verschillende andere behandleingen gehad en waren op moment van starten met deze aanpak in principe onbehandelbaar en in vergevorderd stadium van hun ziekte. Een groep van 48 patiënten kreeg de combinatie therapie van hyperthermie en intraveneus vitamine C plus beste zorg, een groep van 47 patiënten alleen beste zorg. Ziektestadium en en lichamelijke en geestelijke gesteldheid was in beide groepen gelijk. Zie (Table 1).

Na een mediane follow-up van 24 maanden waren de progressievrije overleving (PFS) en de algehele overleving (OS) veel beter door de combinatietherapie van hyperthermie plus vitamine C per infuus naast beste zorg vergeleken met alleen beste zorg.
Het verschil in mediane overall overleving was maar liefst ca. 40 procent beter voor de combinatiegroep (OS: 9,4 maanden vs. 5,6 maanden, P <0,05). De kwaliteit van leven was ook veel beter in de combinatiegroep ondanks het gevorderde ziektestadium. De ziektecontrole (stabiele ziekte) na 3 maanden na start van de behandeling was 42,9% in de combinatiegroep van hyperthermie en vitamine C en 16,7% in de controlegroep van alleen beste zorg (P <0,05). 

Het volledige studierapport: A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer is gratis in te zien.

Hiert het abstract van de studie met referentielijst.

intravenous vitamin C (IVC) + modulated electrohyperthermia (mEHT) is well tolerated, significantly improves QoL, prolongs PFS and OS, and moderates cancer-related inflammation, so it is a feasible treatment in advanced NSCLC.

. 2020 Jul; 24: 175–182.
Published online 2020 Mar 17. doi: 10.1016/j.jare.2020.03.004
PMCID: PMC7190757
PMID: 32368355

A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer

An external file that holds a picture, illustration, etc.
Object name is ga1.jpgGraphical abstract

Abstract

Our previous study indicated that intravenous vitamin C (IVC) treatment concurrent with modulated electrohyperthermia (mEHT) was safe and improved the quality of life (QoL) of non-small-cell lung cancer (NSCLC) patients. The aim of this trial was to further verify the efficacy of the above combination therapy in previously treated patients with refractory advanced (stage IIIb or IV) NSCLC. A total of 97 patients were randomized to receive IVC and mEHT plus best supportive care (BSC) (n = 49 in the active arm, receiving 1 g/kg * d IVC concurrently with mEHT, three times a week for 25 treatments in total) or BSC alone (n = 48 in the control arm). After a median follow-up of 24 months, progression-free survival (PFS) and overall survival (OS) were significantly prolonged by combination therapy compared to BSC alone (PFS: 3 months vs 1.85 months, P < 0.05; OS: 9.4 months vs 5.6 months, P < 0.05). QoL was significantly increased in the active arm despite the advanced stage of disease. The 3-month disease control rate after treatment was 42.9% in the active arm and 16.7% in the control arm (P < 0.05). Overall, IVC and mEHT may have the ability to improve the prognosis of patients with advanced NSCLC.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgments

The authors sincerely thank the patients and investigators.

The study was financed with institutional funds from Clifford L.K. Pang Funding, China [Grant number: 2016-01], and the Major Medical and Health Project of the Department of Science, Technology, Industry, Commerce and Information Bureau in Panyu of Guangzhou [Grant number: 2018-Z04-05].

Consent for publication

Not applicable.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Footnotes

Peer review under responsibility of Cairo University.

Appendix ASupplementary data to this article can be found online at https://doi.org/10.1016/j.jare.2020.03.004.

Appendix A. Supplementary material

The following are the Supplementary data to this article:

Supplementary data 1:

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