13 novermber 2010: Zie ook recente overzichtstudie van Cochrane Database review: Klik hier voor artikel

15 mei 2008: Bron: 1: Am J Gastroenterol. 2006 Apr;101(4):812-22.Click here to read Links

Probiotica gaat diarree veroorzaakt door antibiotica significant tegen blijkt uit overzichtstudie van alle onderzoeken, van fase I studies tot gerandomiseerde fase II en III studies,,  die er wereldwijd zijn gedaan en gepubliceerd  in de periode 1977 tot 2005. Samenvattende conclusie is dat probiotica significant een positief effect blijkt te hebben op het wegblijven of controleren van diarree ontstaan door antibiotica gebruik.

Comment in:
ACP J Club. 2006 Sep-Oct;145(2):46.
Am J Gastroenterol. 2007 Jan;102(1):201-2.
Am J Gastroenterol. 2007 Jan;102(1):201; author reply 202-4.
Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease.

Department of Health Services Research and Development, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98101, USA.

CONTEXT: Antibiotic-associated diarrhea (AAD) is a common complication of most antibiotics and Clostridium difficile disease (CDD), which also is incited by antibiotics, is a leading cause of nosocomial outbreaks of diarrhea and colitis. The use of probiotics for these two related diseases remains controversial.

OBJECTIVE: To compare the efficacy of probiotics for the prevention of AAD and the treatment of CDD based on the published randomized, controlled clinical trials.

DATA SOURCES: PubMed, Medline, Google Scholar, NIH registry of clinical trials, metaRegister, and Cochrane Central Register of Controlled Trials were searched from 1977 to 2005, unrestricted by language. Secondary searches of reference lists, authors, reviews, commentaries, associated diseases, books, and meeting abstracts.

STUDY SELECTION: Trials were included in which specific probiotics given to either prevent or treat the diseases of interest. Trials were required to be randomized, controlled, blinded efficacy trials in humans published in peer-reviewed journals. Trials that were excluded were pre-clinical, safety, Phase 1 studies in volunteers, reviews, duplicate reports, trials of unspecified probiotics, trials of prebiotics, not the disease being studied, or inconsistent outcome measures. Thirty-one of 180 screened studies (totally 3,164 subjects) met the inclusion and exclusion criteria.

DATA EXTRACTION: One reviewer identified studies and abstracted data on sample size, population characteristics, treatments, and outcomes.

DATA SYNTHESIS: From 25 randomized controlled trials (RCTs), probiotics significantly reduced the relative risk of AAD (RR = 0.43, 95% CI 0.31, 0.58, p < 0.001). From six randomized trials, probiotics had significant efficacy for CDD (RR = 0.59, 95% CI 0.41, 0.85, p = 0.005).

CONCLUSION: A variety of different types of probiotics show promise as effective therapies for these two diseases. Using meta-analyses, three types of probiotics (Saccharomyces boulardii, Lactobacillus rhamnosus GG, and probiotic mixtures) significantly reduced the development of antibiotic-associated diarrhea. Only S. boulardii was effective for CDD.

PMID: 16635227 [PubMed - indexed for MEDLINE]

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