Lees aub de waarschuwing voor dr. Robert Gorter en het Medisch Centrum Keulen. Dr. Robert Gorter is in opspraak geraakt in Duitsland en Egypte en ook wij distantiëren ons van dr. Robert Gorter. Klik hier of onder vragen voor uitvoerige uitleg waarom wij dr. Robert Gorter geen betrouwbare arts meer vinden.

26 maart 2005: Am J Clin Oncol. 2005 Feb;28(1):91-9.

Combinatie van chemo en radiotherapie - bestraling - aangevuld met hyperthermie zorgt voor langere ziektevrije periode en meer overlevingen bij patiënten met rectumkanker fase II zonder aantoonbare uitzaaiïngen en bespaart bovendien significant vaker de functie van de anus aldus de resultaten uit een gerandomiseerd fase II onderzoek bij 50 deelnemers. Chemoradiotherapy combined with intracavitary hyperthermia for anal cancer: feasibility and long-term results from a phase II randomized trial.

Kouloulias V, Plataniotis G, Kouvaris J, Dardoufas C, Gennatas C, Uzunoglu N, Papavasiliou C, Vlahos L. Aretaieion University Hospital, Radiology Department, Athens, Greece. vkouloul@cc.ece.ntua.gr

PURPOSE: The purpose of this study was to investigate in a randomized way the clinical benefit of addition of intracavitary hyperthermia (ICHT) to a conventional chemoradiotherapy schedule in patients with T2-T3N0M0 anal cancer.

METHODS AND MATERIALS: Patients were randomly assigned to undergo chemotherapy with 5-fluorouracil (5-FU) and mitomycin-C combined with radiotherapy with (arm A: 24 patients) or without ICHT (arm B: 25 patients). A microwave applicator operating at 433 MHz inserted into the anal-rectal cavity was used for ICHT. Patients in both arms received 1000 mg/m2 per day of 5-FU on days 1-4 and days 28-31 plus 15 mg/m mitomycin-C on day 1. Radiotherapy was administered with a dose of 41.4 Gy (1.8 Gy per fraction) plus a booster dose of 14 Gy (2 Gy per fraction).

RESULTS: One patient from group A developed severe mucositis, whereas no severe morbidity was noted in the rest of the patients in both groups. The incidence of lower-intestine acute reactions was higher in the ICHT arm. After a 5-year follow up in the hyperthermia arm, 23 of 24 patients (95.8%) preserved their anorectal function and avoided permanent colostomy, whereas in the second arm, 17 of 25 (68.0%) had sphincter preservation. Local recurrence-free survival time was significantly higher in the ICHT arm (P = 0.0107, log rank test), whereas no significant difference in overall survival was noted.

CONCLUSION: The addition of ICHT to the chemoradiotherapy schedule of anal cancer seems to offer a new effective and safe therapeutic modality. The preservation of anorectal function seems to be the significant clinical benefit of adjuvant ICHT.

PMID: 15685041 [PubMed - in process]


Plaats een reactie ...

Reageer op "Darmkanker - rectumkanker: Inwendige hyperthermie uitgevoerd naast chemo en bestraling bij rectumkanker geeft langere ziektevrije periode en meer overlevingen en bespaart bovendien significant vaker de anale functies"


Gerelateerde artikelen
 

Gerelateerde artikelen

Darmkanker: TACE: Hyperthermie >> Darmkankers: Hyperthermie >> Darmkanker - rectumkanker: >> Darmkanker: Hyperthermie naast >>