Natrium seleniet voorkomt significant lymfe oedeem bij operatieve ingreep bij mondkanker

13 september 2005: bron: Biol Trace Elem Res. 2005 Sep;106(3):193-204.

De waarde van selenium en natrium seleniet in een behandeling van kanker wordt algemeen erkend en is vaak al bewezen, zie ook het boek Voedingsinterventie van arts-bioloog drs. E. Valstar. In een nieuwe kleinschalige - 20 deelnemers - maar wel gerandomiseerde studie blijkt natriumseleniet lymfoedeem samenhangend met een operatie voor mondkanker significant tegen te gaan. Vooral wanneer natrium seleniet direct na de operatie wordt toegediend waar het niet mogelijk of wenselijk is om met manuele vochtdrainage te werken, is het effect heel erg groot. Hier twee studies achter elkaar die hetzelfde bewijzen.

Reduction of postoperative lymphedema after oral tumor surgery with sodium selenite.

Zimmermann T, Leonhardt H, Kersting S, Albrecht S, Range U, Eckelt U.
Department for Visceral, Thoracic and Vascular Surgery of "Carl Gustav Carus" University Hospital at the Technical University of Dresden, Germany.

The objective of this double-blind, randomized study was to establish whether sodium selenite administered orally or intravenously reduces postoperative lymphedema after oral tumor surgery and to study the effect of sodium selenite on glutathione peroxidase (GPX) activity and oxygen radical production.
Twenty patients were enrolled in the study. Each of the participants received 1000 microg sodium selenite intravenously or orally daily for 3 wk during the pre-, intra-, and postoperative period. The extent of lymphedema was measured for 2 wk and the plasma and whole-blood selenium concentration, GPX, reactive oxygen species (ROS), NO, and malonic dialdehyde were measured for 1 yr postoperatively. There was an inverse correlation between the severity of the lymphedema and the whole-blood/plasma selenium concentration and GPX activity. In addition, a positive correlation between the ROS concentration and the extent of lymphedema was observed. A significant reduction of lymphedema occurred in the sodium selenite-treated group. It is concluded that sodium selenite represents a suitable adjuvant treatment of secondary lymphedema in surgically treated patients with tumors in the oral and maxillofacial areas. Treatment with sodium selenite is especially advantageous as it can be instituted immediately after surgery prior to wound healing when manual lymphatic decongestion therapy cannot be applied.

PMID: 16141467 [PubMed - in process]

Onderstaande studie bewijst hetzelfde effect van natrium seleniet als post operatieve behandeling ter voorkoming van lymfoedeem bij operatieve ingreep van hoofd/hals tumoren:

Med Princ Pract. 2004 Jul-Aug;13(4):185-90.

Selenium in the treatment of head and neck lymphedema.

Bruns F, Buntzel J, Mucke R, Schonekaes K, Kisters K, Micke O.
Department of Radiotherapy, Medical School Hannover, Hannover, Germany.

OBJECTIVE: To investigate the impact of selenium in the treatment of lymphedema of the head and neck region after radiotherapy alone or in combination with surgery.

SUBJECTS AND MATERIALS: Between June 1996 and June 2001 a total of 36 cancer patients (29 male, 7 female; median age 61 years) were treated with selenium for persistent, extensive or progressive lymphedema of the head and neck region. Twenty had interstitial endolaryngeal edema associated with stridor and dyspnea. All patients received 350 microg/m(2) body surface sodium selenite medication p.o. daily (total dose 50 microg per day) for a period of 4-6 weeks after radiotherapy. The optimal effect of the selenium treatment was assessed after 4 weeks of therapy using the Miller score system. A visual analogue scale on a scale of 0-10 was used to assess the patient's quality of life prior to and after selenium.

RESULTS: 75% of the patients had an improvement of the Miller score of one stage or more. The self-assessment of quality of life using the visual analogue scale improved significantly after selenium treatment with a reduction of 4.4 points (p < 0.05). Of the 20 patients with endolaryngeal edema tracheostomy was not necessary in 13 patients (65%), but 5 and 2 received a temporary or permanent tracheostomy, respectively. No episode of erysipelas was observed in all study patients.

CONCLUSION: Our results suggest a short positive effect of sodium selenite on secondary head and neck lymphedema caused by radiotherapy alone or in combination with surgery. Copyright 2004 S. Karger AG, Basel

Publication Types:
Clinical Trial

PMID: 15181321 [PubMed - indexed for MEDLINE]

keelkanker, neuskanker, keelkanker, mondkanker, natrium seleniet