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8 september 2015: zie ook dit artikel:

kurkuma-curcumine-supplementen-beschermt-vrouwen-met-borstkanker-tegen-huidschade-dermatitis-door-bestraling-met-60-procent-verschil-copy-1

8 september 2015: bron: Br J Radiol. June 2014; 87(1038): 20130490. Published online 2014 May 5. doi: 10.1259/bjr.20130490

Een zalf met sandelhoutolie en tumeric - curcuma erin voorkomt veel beter dermatitis - huidschade door bestraling dan babyolie bij patiënten met hoofd-halstumoren (mond- en keelkanker) die daarvoor werden bestraald. Het verschil van graad 3 optredende dermatitis bedroeg ca. 75% in effectiviteit: 9.5% kreeg graad 3 dermatitis in de curcuma bevattende zalfgroep versus 37.5% voor de babyolie groep (p < 0.01).

Ook duurde het langer voordat patiënten die de curcuma bevattende zalf gebruikten voor er een huidbeschadiging optrad dan bij de babyolie. En in het studierapport wordt melding gemaakt dat wanneer bij de patiënten uit de babyoliegroep dermatitis optrad de curcuma bevattende zalf dit nog gedeeltelijk herstelde.

Hier een fotoreeks van gradatie van dermatitis:

Ik heb al eerder gezegd dat ik levertraanzalf gebruikte tijdens de bestraling met goede resultaten. En zie ook het artikel in gerelateerde artikelen over curcuma suppletie bij borstkankerpatiënten die bestraald werden met enorme verschillen in dermatitis die optrad door de bestraling.

Hier de resultaten in een grafiek weergegeven bij de patiënten met hoofd- halstumoren:

Het volledige studierapport: Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study is gratis in te zien, dus ik vertaal maar niet alles.

Deze studie is uitgevoerd door een bedrijf dat de door hun zelf ontwikkelde en gebruikte zalf als merknaam uitvent, maar het lijkt mij dat een andere zalf die curcuma en sandelhoutolie bevat waarschijnlijk hetzelfde effect zal geven. Het is zo ergelijk dat aan fabrikanten gevraagd wordt om dit soort studies tegen heel veel geld te moeten laten uitvoeren. terwijl gebruikersstudies met geen merknaam maar wel met de ingredienten zoveel sneller resultaat op zou kunnen leveren.

Hier het abstract van de studie:

VTC - Vicco® turmeric cream is shown to be effective in preventing radiodermatitis

Br J Radiol. June 2014; 87(1038): 20130490.

Published online 2014 May 5. doi: 10.1259/bjr.20130490

PMCID: PMC4075548

Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study

P L Palatty, MB BS, MD,¹ A Azmidah, MB BS,² S Rao, MB BS, MD,^3,^* D Jayachander, MB BS, MD,³ K R Thilakchand, MB BS,² M P Rai, MB BS,^2,^* R Haniadka, MB BS,² P Simon, MB BS,² R Ravi, MB BS,² R Jimmy, MB BS,^2,^* P F D'souza, MB BS,² R Fayad, MB BS, MD,⁴ and M S Baliga, MSc, PhD²

Author information ► Article notes ► Copyright and License information ►

Abstract

Objective:

The study objective was to assess the effectiveness of a turmeric- and sandal wood oil-containing cream [Vicco® turmeric cream (VTC); Vicco Laboratories, Parel, India] on radiodermatitis in patients with head and neck cancer undergoing radiotherapy.

Methods:

A total of 50 patients with head and neck cancer requiring >60 Gy of curative radiotherapy/chemoradiotherapy were enrolled in the study. The volunteers were randomly divided into two groups of 25 patients. Group 1 was assigned to a topical application of Johnson's® baby oil (Johnson & Johnson Ltd, Baddi, India) and Group 2 for VTC. Prophylactic application of the cream was initiated on Day 1 and continued every day until 2 weeks after the end of treatment. Both agents were symmetrically applied within the irradiated field five times a day, and the acute skin reactions were assessed twice weekly in accordance with the Radiation Therapy Oncology Group scores by an investigator who was unaware of the details.

Results:

The incidence of radiodermatitis increased with the exposure to radiation and was the highest in both groups at Week 7. However, a significant reduction in grades of dermatitis were seen in cohorts applying VTC at all time points, including 2 weeks post radiotherapy (p < 0.015 to p < 0.001). The occurrence of Grade 3 dermatitis was lower in the cohorts using VTC and was statistically significant (p < 0.01). Additionally, follow-up observations 2 weeks after the completion of radiotherapy also showed a reduced degree of radiodermatitis in cohorts applying VTC, which was significant (p = 0.015).

Conclusion:

VTC is shown to be effective in preventing radiodermatitis and needs to be validated in larger double-blind trials.

Advances in knowledge:

For the first time, this study shows that the turmeric- and sandal oil-based cream was effective in preventing radiation-induced dermatitis.

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tumeric, curcuma, zalf met sandelhoutolie en curcuma, hoofd- halstumoren, bestraling, dermatitis, huidschade door bestraling