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28 juni 2012: veel meer over PDT - Photo Dynamische Therapie kunt u hier vinden

Uit onderstaande studie blijkt dat Photodynamische therapie een zeer goed alternatief kan zijn voor een operatieve verwijdeirng van tumoren bij een recidief van borstkanker waar eerder al is geopereerd. Het lijkt erop dat de nieuwe operatietechnieken zoals R.F.A. en nu ook fotodynamische therapie de klassieke behandelmethoden steeds vaker zullen worden ingezet. Fotodynamische therapie is ook al succesvol toegepast bij inoperabele alvleesklierkanker. Zie onder dit artikel 15 studies vermeld in Medline die hebben aangetoond dat fotodynamische therapie een goed en bruikbaar alternatief kan zijn. In het Anthonie van Leeuwenhoek is een speciale afdeling PDT - Photo Dynamische Therapie.

Photodynamic therapy of locoregional breast cancer recurrences
using a chlorin-type photosensitizer.

Wyss P, Schwarz V, Dobler-Girdziunaite D, Hornung R, Walt H, Degen A, Fehr

Department of Obstetrics and Gynecology, University Hospital, Zurich, Switzerland.

Chest wall recurrences are a frequent problem in patients treated by mastectomy for
breast cancer.Photodynamic therapy (PDT) provides an alternative treatment modality
using a photosensitizer and laser light to induce selective tumor necrosis. PDT was
performed as compassionate use in 7 patients aged 57.6 years (+/-12.6 SD). A total
of 89 metastatic skin nodes were treated in 11 PDT sessions. As photosensitizer
was applied intravenously. Patients (n = 3) photosensitized with a drug dose of
0.10 mg/kg bodyweight were irradiated 48 hr after drug application at a lightdose of 5 J/cm(2). Patients (n = 4) were illuminated by an optical dose of 10 J/cm(2) 96 hr after photosensitization with 0.15 mg/kg. 

Laserlight at a wavelength of 652 nm was generated by a diode laser and applied by a
front lens light diffuser using a fluence rate of 20--25 mW/cm(2). PDT using m-THPC
resulted in complete response in all patients. Response to treatment did not differ
when using the 2 different drugdose protocols. Healing time depended mainly on the
size of the illumination field but not on the lightdose. Pain score usually raised 1 day
after PDT and lasted at higher levels for about 10 days. Healing time usually ranged
between 8--10 weeks. Photodynamic technique offers a minimal-invasive, outpatient
treatment modality for recurrent breast cancer on the chest wall with few side effects,
high patient's satisfaction and with possible repetitive application. Copyright 2001
Wiley-Liss, Inc.

Publication Types: 
Clinical trial 
Controlled clinical trial 

PMID: 11477585 [PubMed - indexed for MEDLINE] 


Hieronder 15 studies waar bij veel verschillende soorten kanker fotodynamische therapie is toegepast.

Bauer TW, Hahn SM, Spitz FR, Kachur A, Glatstein E, Fraker DL.

Preliminary report of photodynamic therapy for intraperitoneal sarcomatosis.
Ann Surg Oncol. 2001 Apr;8(3):254-9.
PMID: 11314943 [PubMed - indexed for MEDLINE]

Rumalla A, Baron TH, Wang KK, Gores GJ, Stadheim LM, de Groen PC.

Endoscopic application of photodynamic therapy for cholangiocarcinoma.
Gastrointest Endosc. 2001 Apr;53(4):500-4.
PMID: 11275896 [PubMed - indexed for MEDLINE]

Nakamura H, Kawasaki N, Hagiwara M, Ogata A, Kato H.

Endoscopic evaluation of centrally located early squamous cell carcinoma of the lung.
Cancer. 2001 Mar 15;91(6):1142-7.
PMID: 11267959 [PubMed - indexed for MEDLINE]

Hendren SK, Hahn SM, Spitz FR, Bauer TW, Rubin SC, Zhu T, Glatstein E, Fraker

Phase II trial of debulking surgery and photodynamic therapy for disseminated
intraperitoneal tumors.
Ann Surg Oncol. 2001 Jan-Feb;8(1):65-71.
PMID: 11206227 [PubMed - indexed for MEDLINE]

Rosenthal MA, Kavar B, Hill JS, Morgan DJ, Nation RL, Stylli SS, Basser RL, Uren
S, Geldard H, Green MD, Kahl SB, Kaye AH.

Phase I and pharmacokinetic study of photodynamic therapy for high-grade gliomas
using a novel boronated porphyrin.
J Clin Oncol. 2001 Jan 15;19(2):519-24.
PMID: 11208846 [PubMed - indexed for MEDLINE]

Berr F, Wiedmann M, Tannapfel A, Halm U, Kohlhaw KR, Schmidt F, Wittekind C,
Hauss J, Mossner J.

Photodynamic therapy for advanced bile duct cancer: evidence for improved
palliation and extended survival.
Hepatology. 2000 Feb;31(2):291-8.
PMID: 10655248 [PubMed - indexed for MEDLINE]

Hirschberg H, Madsen S, Lote K, Pham T, Tromberg B.

An indwelling brachytherapy balloon catheter: potential use as an intracranial light
applicator for photodynamic therapy.
J Neurooncol. 1999 Aug;44(1):15-21.
PMID: 10582664 [PubMed - indexed for MEDLINE]

Bernstein ZP, Wilson BD, Oseroff AR, Jones CM, Dozier SE, Brooks JS, Cheney
R, Foulke L, Mang TS, Bellnier DA, Dougherty TJ.

Photofrin photodynamic therapy for treatment of AIDS-related cutaneous Kaposi's
AIDS. 1999 Sep 10;13(13):1697-704.
PMID: 10509571 [PubMed - indexed for MEDLINE]

Kriegmair M, Zaak D, Knuechel R, Baumgartner R, Hofstetter A.

Photodynamic cystoscopy for detection of bladder tumors.
Semin Laparosc Surg. 1999 Jun;6(2):100-3.
PMID: 10459062 [PubMed - indexed for MEDLINE]

Kashtan H, Konikoff F, Haddad R, Skornick Y.

Photodynamic therapy of cancer of the esophagus using systemic aminolevulinic
acid and a non laser light source: a phase I/II study.
Gastrointest Endosc. 1999 Jun;49(6):760-4.
PMID: 10343224 [PubMed - indexed for MEDLINE]

Alecu M, Ursaciuc C, Halalau F, Coman G, Merlevede W, Waelkens E, de Witte

Photodynamic treatment of basal cell carcinoma and squamous cell carcinoma with
Anticancer Res. 1998 Nov-Dec;18(6B):4651-4.
PMID: 9891535 [PubMed - indexed for MEDLINE]

Taber SW, Fingar VH, Coots CT, Wieman TJ.

Photodynamic therapy using mono-L-aspartyl chlorin e6 (Npe6) for the treatment of
cutaneous disease: a Phase I clinical study.
Clin Cancer Res. 1998 Nov;4(11):2741-6.
PMID: 9829737 [PubMed - indexed for MEDLINE]

Hurlimann AF, Hanggi G, Panizzon RG.

Photodynamic therapy of superficial basal cell carcinomas using topical
5-aminolevulinic acid in a nanocolloid lotion.
Dermatology. 1998;197(3):248-54.
PMID: 9812030 [PubMed - indexed for MEDLINE]

Fink-Puches R, Soyer HP, Hofer A, Kerl H, Wolf P.

Long-term follow-up and histological changes of superficial nonmelanoma skin
cancers treated with topical delta-aminolevulinic acid photodynamic therapy.
Arch Dermatol. 1998 Jul;134(7):821-6.
PMID: 9681345 [PubMed - indexed for MEDLINE]

Nseyo UO.

Photodynamic therapy in the management of bladder cancer.
J Clin Laser Med Surg. 1996 Oct;14(5):271-80.
PMID: 9612193 [PubMed - indexed for MEDLINE]

Muller PJ, Wilson BC.

Photodynamic therapy for malignant newly diagnosed supratentorial gliomas.
J Clin Laser Med Surg. 1996 Oct;14(5):263-70.
PMID: 9612192 [PubMed - indexed for MEDLINE]

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