Adressen van TCM artsen en acupunctuur staan in dit artikel: 

https://kanker-actueel.nl/adressen-van-betrouwbare-tcm-artsen-en-acupuncturisten.html

19 september 2016: lees ook dit artikel: 

https://kanker-actueel.nl/NL/tcm-traditionele-chinese-medicijnen-naast-westerse-medicijnen-voor-gevorderde-niet-kleincellige-longkanker-geeft-langere-levensduur-betere-kwaliteit-van-leven-in-vergelijking-met-alleen-westerse-medicijnen.html

8 juni 2016: Bron: Complement Ther Med. 2016 Feb;24:55-62. doi: 10.1016/j.ctim.2015.12.006. Epub 2015 Dec 17

Wanneer patienten met vergevorderde niet-klein-cellige longkanker als onderhoudsbehandeling TCM - Traditionele Chinese Medicijnen krijgen in plaats van chemo (docetaxel, pemetrexed of gemcitabine) dan hebben deze patienten een veel betere kwaliteit van leven. Bovendien stijgt de mediane overall overleving met ca. 3 maanden (21.5 maanden vs. 18.8 maanden, P=0.601) en blijken er op 1-jaars meting meer mensen nog in leven (78.1% vs. 53.1%, P=0.035). 

Dit blijkt uit een gerandomiseerde fase II studie bij totaal 71 patiënten met vergevorderde niet-kleincellige longkanker waarvan er 64 konden worden geëvalueerd omdat er 7 patiënten niet aan de toelatingscriteria voldeden. Of artsen hier in het westen deze studie accepteren betwijfel ik want er is een vloeistof gebruikt van kikkerhuid voor de injecties. Injecties die overigens al jarenlang worden gebruikt met name bij longkanker, zie verderop studies daarmee gedaan.

Bufo bufo gargarizans Cantor

Foto: Bufo bufo gargarizans

Studieresultaten:

In deze gerandomiseerde studie werden 64 patiënten met niet-klein-cellige longkanker opgenomen die in eerste instantie goed reageerden op een standaardbehandeling. De 64 patienten werden 1 op 1 gerandomiseerd ingedeeld in twee groepen: een TCM groep werd behandeld met een Chinees kruid via een injectie (Cinobufacini, 20 ml/d, d1–d10), een afkooksel van verschillende kruiden (d1–d21) en een Chinese acupunture applicatie (d1–d21), n = 32). De tweede groep kreeg alleen chemotherapie (of met Alimta -  pemetrexed (non-squamous NSCLC, 500 mg/m2, d1) en docetaxel (75 mg/m2, d1) of met gemcitabine (1250 mg/m2, d1 and d8), n  = 32). Een behandelingskuur durude 21 dagen.  De kuren werden herhaald tot zich progressie voordeed of ontoelaastbare bijwerkingen gaf of op verzoek van de patient om te stoppen emt de behandeling.Primaire doel was tijd tot zich progressie voordeed. Secondaire doelen waren kwaliteit van leven, 1-jaars overleving en overall overleving.

Hier een grafiek van de deelnemers verdeeld over de twee groepen:

TCM studie bij longkanker

Resultaten:

Een TCM behandeling verlengde de tijd tot zich progressie voordeed met enkele weken meer dan voor de chemogroep. (3.0 maanden vs. 2.3 maanden, P = 0.114). Mediane overall overleving werd ca. 3 maanden langer maar was niet statistisch significant (21.5 maanden vs. 18.8 maanden, P = 0.601). 1-jaars overleving was daarentegen wel statistisch significant in het voordeel van de TCM groep:  (78.1% vs. 53.1%, P  = 0.035). Ook bleek de kwaliteit van leven getoetst aan de EORTC QLQ-C30 en EORTC QLQ-LC13 QOL tabellen statistisch significant beter voor de TWM groep in vergelijking met de chemogroep.

TCM studie bij longkanker OS grafiek

Conclusie:

Een onderhoudsbehandeling met TCM - Traditionele Chinese Medicijnen had hetzelfde effect op tijd tot zich progressie voordeed maar verbeterde de 1-jaars overleving en kwaliteit van leven. Een TCM onderhoudsbehandeling kan dus een verdedigbare behandelingsoptie zijn voor patienten met gevorderde niet-klein-cellige longkanker op moment dat sprake is van stabiele ziekte door chemotherapie. 


Het volledige studierapport: Traditional Chinese Medicine treatment as maintenance therapy in advanced non-small-cell lung cancer: A randomized controlled trial is gratis in te zien. Er ook aan toegevoegd de referentielijst die is gebruikt bij deze studie.

En zie ook deze reviewstudie van de effecten van de vloeistof van kikkerhuid in deze studie bij niet-kleincellige longkanker: Is Huachansu Beneficial in Treating Advanced Non-Small-Cell Lung Cancer? Evidence from a Meta-Analysis of Its Efficacy Combined with Chemotherapy.

Hier het abstract van de studie hirboven beschreven:

TCM maintenance treatment had similar effects on TTP and OS compared with maintenance chemotherapy, but it improved patients' QOL and had higher 1-year survival rate. TCM Maintenance treatment is a promising option for advanced NSCLC patients without progression following first-line chemotherapy.

Complement Ther Med. 2016 Feb;24:55-62. doi: 10.1016/j.ctim.2015.12.006. Epub 2015 Dec 17.

Traditional Chinese Medicine treatment as maintenance therapy in advanced non-small-cell lung cancer: A randomized controlled trial.

Abstract

OBJECTIVES:

Maintenance therapy for patients with advanced non-small-cell lung cancer (NSCLC) is an increasingly hot topic in the field of clinical NSCLC research. This study aimed to evaluate the effects of Traditional Chinese Medicine (TCM) treatment as maintenance therapy on time to progression (TTP), quality of life (QOL), overall survival (OS) and 1-year survival rate in patients with advanced NSCLC.

METHODS:

This study was conducted as a randomized, controlled, open-label trial. 64 non-progressive patients who responded to initial therapy were randomized 1:1 to the TCM arm (treated with herbal injection (Cinobufacini, 20ml/d, d1-d10), herbal decoction (d1-d21) and Chinese acupoint application (d1-d21), n=32) or to the chemotherapy arm (treated with pemetrexed (non-squamous NSCLC, 500mg/m(2), d1), docetaxel (75mg/m(2), d1) or gemcitabine (1250mg/m(2), d1 and d8), n=32). Each therapy cycle was 21 days. They were repeated until disease progression, unacceptable toxicity, or until the patients requested therapy discontinuation. The primary end point was TTP; the secondary end points were QOL, OS and 1-year survival rate. "Intention-to-treat" analysis included all randomized participants.

RESULTS:

TCM treatment prolonged median TTP for 0.7 months compared with chemotherapy, but it was not statistically significant (3.0 months vs. 2.3 months, P=0.114). Median OS time for TCM treatment did not offer a significant advantage over for chemotherapy (21.5 months vs. 18.8 months, P=0.601). 1-year survival rate of TCM treatment significantly improved than that of chemotherapy (78.1% vs. 53.1%, P=0.035). TCM treatment can significantly improve QOL when compared to chemotherapy as assessed by EORTC QLQ-C30 and EORTC QLQ-LC13 QOL instruments.

CONCLUSIONS:

TCM maintenance treatment had similar effects on TTP and OS compared with maintenance chemotherapy, but it improved patients' QOL and had higher 1-year survival rate. TCM Maintenance treatment is a promising option for advanced NSCLC patients without progression following first-line chemotherapy.

Copyright © 2015 Elsevier Ltd. All rights reserved.

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This study demonstrated the efficacy of Huachansu combined with chemotherapy in the treatment of advanced NSCLC. However, limitations exist and high-quality trials are needed for further verification.

Evid Based Complement Alternat Med. 2015;2015:408145. doi: 10.1155/2015/408145. Epub 2015 Aug 11.

Is Huachansu Beneficial in Treating Advanced Non-Small-Cell Lung Cancer? Evidence from a Meta-Analysis of Its Efficacy Combined with Chemotherapy.

Abstract

Background. Huachansu, the sterilized water extract of Bufo bufo gargarizans toad skin, is used in China to alleviate the side-effects and enhance the therapeutic effect of chemotherapy in advanced non-small-cell lung cancer (NSCLC). We conducted a meta-analysis to assess Huachansu's efficacy. Methods. We extensively searched electronic databases (CENTRAL, EMBASE, MEDLINE, CBM, Cochrane Library, CNKI, CEBM, WFDP, CSCD, CSTD, and IPA) for randomized controlled trials containing Huachansu plus chemotherapy as the test group and chemotherapy as the control group. Seventeen trials were selected based on the selection criteria. The pooled relative ratio (RR) of indicators with 95% confidence interval (95% CI) was calculated for efficacy evaluation. Results. The meta-analysis demonstrated a statistically significant improvement in objective tumor response, one-year survival, Karnofsky performance status, pain relief, and alleviation of severe side-effects (nausea and vomiting, leukocytopenia) in the test group as compared to the control group, but no significant difference in thrombocytopenia. Conclusions. This study demonstrated the efficacy of Huachansu combined with chemotherapy in the treatment of advanced NSCLC. However, limitations exist and high-quality trials are needed for further verification.

PMID:
26347788
PMCID:
PMC4548072

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