Raadpleeg ook de literatuurlijsten van niet-toxische middelen en behandelingen bij individuele vormen van kanker en chemo en bestraling en operatie en stamceltransplantaties 

14 november 2018: Bron: . 2018; 18: 288. Published online 2018 Mar 13.

Al heel lang wordt onderzocht wat aspirinegebruik doet bij kanker. Werkt het preventief? Voorkomt het een recidief? Wat zijn de bijwerkingen en gevaren van langdurig aspirinegebruik? 

Hier hebben we een aantal studiepublicaties bij elkaar gebracht in een overzicht, zie in gerelateerde artikelen. (tekst gaat verder onder beeld)

aspirine_500

Maar raadpleeg ook deze reviewstudie / meta analyse: 

Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

De belangrijkste resultaten uit 218 artikelen uit de periode tussen 1985 en 2016 zijn samengevat in grafieken uitgesplitst naar vorm van kanker.

Klik op de grafieken voor de resultaten en studies per vorm van kanker:  1, ​,2,2, ​,3,3, ​,4,4, ​,5,5, ​,6,6, ​,7,7, ​,8,8, ​,9,9, ​,10,10, ​,11,11, ​,12,12, ​,13,13, ​,14,14, ​,15,15, ​,16,16, ​,17,17, ​,18,18, ​,19,19, ​,2020 en ​and21.21.

Deze studie omvatte in totaal 161 cohortstudies en 148 case-control studies. Onder hen zijn 135 studies uitgevoerd in Noord-Amerika, 12 in Azië, 61 in Europa, 8 in Oceanië en 2 in meerdere landen. Over het algemeen was de samengevatte RR 0.89 (95% CI: 0.87-0.91), wat wijst op een verminderd risico op kanker geassocieerd met het gebruik van aspirine. De gecombineerde RR's waren 0,82 (95% CI: 0,79-0,85) voor de case-control studies en 0,94 (95% CI: 0,92-0,97) voor de cohortstudies.

Samenvattend lijkt langdurig aspirinegebruik dus verschillende vormen van kanker te kunnen voorkomen. 

Genoemd worden maagkanker, darmkanker, slokdarmkanker, borstkanker, alvleesklierkanker, eierstokkanker, endometriosekanker (buikvlieskanker), prostaatkanker en neuro endocriene tumoren in de spijsverteringskanalen

maar er wordt ook gewaarschuwd voor de gevaren en bijwerkingen. O.a. is een van de gevaren dat inwendige bloedingen door langdurig aspirinegebruik kunnen ontstaan.

Hier de originele conclusie van deze meta-analyse met onderaan artikel het abstract en referentielijst. . 

Evidence from observational studies indicates that utilization of aspirin is associated with reduced risk of gastric, colorectal, esophageal, pancreatic, ovarian, endometrial, breast, and prostate cancers, in addition to small intestine neuroendocrine tumors. A stronger protective effect was observed in the North American populations and patients who used aspirin for at least 5 years. It is important to address immortal time bias not only to ensure the integrity of the meta-analysis, but also to ensure the integrity of pharmacoepidemiological studies. Moreover, given the confidence limits of the evaluated studies, adequately powered mechanistic studies should help elucidate the mechanisms underlying this correlation.

Hier het abstract plus referentielijst:

These findings suggest that aspirin use is associated with a reduced risk of gastric, esophageal, colorectal, pancreatic, ovarian, endometrial, breast, and prostate cancers, and small intestine neuroendocrine tumors.

. 2018; 18: 288.
Published online 2018 Mar 13. doi:  [10.1186/s12885-018-4156-5]
PMCID: PMC5851082
PMID: 29534696

Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Abstract

Background

Epidemiological studies have clarified the potential associations between regular aspirin use and cancers. However, it remains controversial on whether aspirin use decreases the risk of cancers risks. Therefore, we conducted an updated meta-analysis to assess the associations between aspirin use and cancers.

Methods

The PubMed, Embase, and Web of Science databases were systematically searched up to March 2017 to identify relevant studies. Relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of associations.

Results

A total of 218 studies with 309 reports were eligible for this meta-analysis. Aspirin use was associated with a significant decrease in the risk of overall cancer (RR = 0.89, 95% CI: 0.87–0.91), and gastric (RR = 0.75, 95% CI: 0.65–0.86), esophageal (RR = 0.75, 95% CI: 0.62–0.89), colorectal (RR = 0.79, 95% CI: 0.74–0.85), pancreatic (RR = 0.80, 95% CI: 0.68–0.93), ovarian (RR = 0.89, 95% CI: 0.83–0.95), endometrial (RR = 0.92, 95% CI: 0.85–0.99), breast (RR = 0.92, 95% CI: 0.88–0.96), and prostate (RR = 0.94, 95% CI: 0.90–0.99) cancers, as well as small intestine neuroendocrine tumors (RR = 0.17, 95% CI: 0.05–0.58).

Conclusions

These findings suggest that aspirin use is associated with a reduced risk of gastric, esophageal, colorectal, pancreatic, ovarian, endometrial, breast, and prostate cancers, and small intestine neuroendocrine tumors.

Electronic supplementary material

The online version of this article (10.1186/s12885-018-4156-5) contains supplementary material, which is available to authorized users.

References:

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