2 febaruari 2012: lees naast onderstaande studie ook deze studie: Intensieve fysieke activiteiten zorgen voor aantoonbaar DNA herstel en gen regulatie bij prostaatkanker patiënten

11 mei 2005: Bron: Arch Intern Med. 2005 May 9;165(9):1005-1010.

Behoorlijk pittige fysieke oefeningen werken preventief in het krijgen van prostaatkanker en lijken prostaatkankergroei behoorlijk te remmen. Een 14 jarige studie volgde ruim 47.000 volwassen mannen. Uit die groep bleken de mannen die veel sporten en wekelijks pittige fysieke oefeningen deden minder vatbaar voor krijgen van prostaatkanker en als ze al prostaatkanker kregen was de kanker minder ver gevorderd bij diagnose en beter Gleasonscores te hebben dan mannen die minder sporten en fysieke oefeningen deden.

A Prospective Study of Physical Activity and Incident and Fatal Prostate Cancer.

Giovannucci EL, Liu Y, Leitzmann MF, Stampfer MJ, Willett WC.
Departments of Nutrition, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Mass.

BACKGROUND: Whether physical activity has benefits against prostate cancer incidence or progression is unclear. Therefore, we assessed physical activity in relation to prostate cancer incidence, mortality, and Gleason histologic grade.

METHODS: We used data from the Health Professionals Follow-up Study, a prospective cohort study, to determine the number of cases of incident, advanced (seminal vesicle invasion, metastasis, or fatal), fatal, and high-grade prostate cancer in a cohort of 47 620 US male health professionals, followed up from February 1, 1986, to January 31, 2000.

RESULTS: During 14 years of follow-up, we documented 2892 new cases of prostate cancer, including 482 advanced cases (280 of which were fatal). For total prostate cancer, no association was observed for total, vigorous, and nonvigorous physical activity. In men 65 years or older, we observed a lower risk in the highest category of vigorous activity for advanced (multivariable relative risk, 0.33; 95% confidence interval, 0.17-0.62, for more than 29 vs 0 metabolic equivalent hours) and for fatal (relative risk, 0.26; 95% confidence interval, 0.11-0.66) prostate cancer. No associations were observed in younger men. Differential screening by prostate-specific antigen or a reduction in physical activity due to undiagnosed prostate cancer did not appear to account for the results. Among cases, men with high levels of physical activity were less likely to be diagnosed with poorly differentiated cancers (Gleason grade >/=7).

CONCLUSION: Although the mechanisms are not yet understood, these findings suggest that regular vigorous activity could slow the progression of prostate cancer and might be recommended to reduce mortality from prostate cancer, particularly given the many other documented benefits of exercise.

PMID: 15883238 [PubMed - as supplied by publisher]

fysieke activiteiten, preventie, prostaatkanker

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• Intensieve fysieke activiteiten van mannen met prostaatkanker zorgt voor aantoonbaar DNA herstel en zou verklaren waarom deze mannen zoveel minder kans hebben - 61 procent - te overlijden aan hun ziekte dan wie niet zoveel lichamelijke activiteiten doen

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• Preventie - prostaatkanker: een overzicht van belangrijke studies en aanbevelingen hoe prostaatkanker is te voorkomen