16 april 2018: lees ook dit artikel: 

https://kanker-actueel.nl/wanneer-kan-rfa-of-ire-nanoknife-of-microwave-of-tace-litt-of-combinaties-ervan-het-beste-worden-toegepast-bij-levertumoren.html

27 juni 2002: bron: Reuters Health en Ann Surg 2002;235:863-871

Onderstaand bericht van een wetenschappelijk onderzoek naar de effecten van operatieve verwijdering van levertumoren lijkt erg belangrijk ook voor de RFA methode. Het maakt geen enkel verschil of een levertumor voor de eerste of tweede of zelfs derde keer wordt verwijderd door operatie. Een terugkomen van levertumoren door uitzaaiingen kan zo dus onder controle worden gebracht. 

NEW YORK (Reuters Health) Jun 27 - Repeat liver resections are as safe and effective as first resections for the removal of metastatic colorectal cancer, according to investigators who evaluated a large patient cohort treated at two surgical oncology centers. 
Dr. Yuman Fong, of Memorial Sloan-Kettering Cancer Center in New York, and colleagues prospectively identified 96 patients who were originally treated at their institution between 1986 and 2001, and 30 patients treated at the oncology center at University of Frankfurt in Germany between 1985 and 1999. All 126 patients underwent second resections. 

The 30-day mortality after the second surgery was 1.6% for all 126 patients, and the 30-day complication rate was 28%, which was not significantly higher than mortality after the first hepatic resection, the investigators report in the Annals of Surgery for June. 

During a median follow-up of 58.8 months, the 1- and 5-year survival rates were 86% and 34%. The median overall survival was 37 months. 

Multivariate analysis identified only two independent risk factors: the number of lesions and the size of the largest lesion at the second resection. Multiple lesions increased the relative risk to 2.82 compared with single lesions, while having a tumor >5 cm increased the risk to 1.89 compared with smaller tumors. Outcome was unrelated to any factors associated with the first resection. 

"In selecting patients for repeat resection," Dr. Fong's team writes, "medical fitness, small solitary tumors, ability to clear all disease, and possibly disease-free interval are the most important criteria for consideration." 

Ann Surg 2002;235:863-871. 


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