Zie ook dit artikel : https://kanker-actueel.nl/synbiotica-ingenomen-7-dagen-voor-operatie-bij-patienten-met-darmkanker-vermindert-kans-op-sterfte-aan-infectie-geeft-korter-ziekenhuisverblijf-en-minder-gebruik-van-antibiotica.html
En dit artikel: https://kanker-actueel.nl/NL/probiotica-melkzuurbacterien-geven-gunstig-preventief-effect-op-voorkomen-van-bijwerkingen-diarree-bij-bestralingen-aldus-gerandomiseerde-studie.html
21 augustus 2024: Bron: International Journal of Radiation Oncology Published:March 12, 2024
Probioticamix vooraf gegeven aan radiotherapie / bestraling op buik en bekken vermindert darmschade en verbetert overleving, vermindert ontstekingsreacties en verbetert darmmicrobiota.
Wanneer kankerpatiënten bestraald worden (radiotherapie) in het gebied van buik en bekken dan ondervinden de meesten behoorlijk wat klachten. Variërend van diarree tot verbranden van de huid tot chronische darmklachten zoals door bestraling geïnduceerde darmbeschadigingen.
In een vergelijkende muizenstudie kregen de helft van de muizen 30 dagen vooraf aan de radiotherapie / bestraling met 13 Gy van de hele buik en bekken een mix van probiotica, te weten Bifidobacterium longum BL21, Lactobacillus paracasei LC86 en Lactobacillus plantarum Lp90. Daarna werden de resultaten vergeleken met een controlegroep muizen, de andere helft, die geen probiotica kregen maar wel dezelfde bestraling.
De probiotica gaf hogere overlevingspercentages te zien, verbeterde klinische scores en verzachtte mucosale schade. Bovendien stimuleerde de probiotica de proliferatie en differentiatie van darmstamcellen, verbeterde het de integriteit van de darmepitheelbarrière en reguleerde het de redox-onbalans en ontstekingsreacties bij bestraalde muizen. Met name veroorzaakte de behandeling een herstructurering van de samenstelling van de darmmicrobiota, met name de verrijking van vetzuurproducerende bacteriën met een korte keten.
Dat probiotica gezondheidsbevorderend is naast chemo, bestraling, immuuntherapie hebben vele patiëntenstudies ook bewezen. Zie bv ook deze recente studie:
Microbiome in radiotherapy: an emerging approach to enhance treatment efficacy and reduce tissue injury
In deze muizenstudie werd heel specifiek de effecten onderzocht op darmschade in buik- en bekkengebied. Met dus een groot verschil in effect tussen behandelingsgroep en controlegroep.Het volledige studieverslag is gratis in te zien met ook referenties naar patiëntenstudies met probiotica.
Purpose
Radiation-induced intestinal injury (RIII) commonly occur during abdominal-pelvic cancer radiation therapy; however, no effective prophylactic or therapeutic agents are available to manage RIII currently. This study aimed to clarify the potential of probiotic consortium supplementation in alleviating RIII.
Methods and Materials
Male C57BL/6J mice were orally administered a probiotic mixture comprising Bifidobacterium longum BL21, Lactobacillus paracasei LC86, and Lactobacillus plantarum Lp90 for 30 days before exposure to 13 Gy of whole abdominal irradiation. The survival rates, clinical scores, and histologic changes in the intestines of mice were assessed. The impacts of probiotic consortium treatment on intestinal stem cell proliferation, differentiation, and epithelial barrier function; oxidative stress; and inflammatory cytokines were evaluated. A comprehensive examination of the gut microbiota composition was conducted through 16S rRNA sequencing, while changes in metabolites were identified using liquid chromatography-mass spectrometry.
Results
The probiotic consortium alleviated RIII, as reflected by increased survival rates, improved clinical scores, and mitigated mucosal injury. The probiotic consortium treatment exhibited enhanced therapeutic effects at the histologic level compared with individual probiotic strains, although there was no corresponding improvement in survival rates and colon length. Moreover, the probiotic consortium stimulated intestinal stem cell proliferation and differentiation, enhanced the integrity of the intestinal epithelial barrier, and regulated redox imbalance and inflammatory responses in irradiated mice. Notably, the treatment induced a restructuring of the gut microbiota composition, particularly enriching short-chain fatty acid-producing bacteria. Metabolomic analysis revealed distinctive metabolic changes associated with the probiotic consortium, including elevated levels of anti-inflammatory and antiradiation metabolites.
Conclusions
The probiotic consortium attenuated RIII by modulating the gut microbiota and metabolites, improving inflammatory symptoms, and regulating oxidative stress. These findings provide new insights into the maintenance of intestinal health with probiotic consortium supplementation and will facilitate the development of probiotic-based therapeutic strategies for RIII in clinical practice.
Appendix. Supplementary materials
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Article info
Publication history
Published online: March 12, 2024
Accepted: March 2, 2024
Received: July 31, 2023
Footnotes
Li-Wei Xie, Hai-Yan Lu, and Lin-Feng Tang made equal contributions to this study.
Disclosures: This work was supported by the Suzhou Medical Center (Szlcyxzx202103), National Natural Science Foundation of China (82192884), the Science and Technology Program of Suzhou (SKY2023121), the Young Talent Support Project of the 2nd Affiliated Hospital of Soochow University (XKTJ-RC202007), the Science Foundation of Jiangsu Health Commission (M2021081), a research project of medical talent of Suzhou (GSWS2021025), extracurricular scientific research projects for students at Medical College of Soochow University (2022YXYKWKY064), the Jiangsu Province College Student Innovation and Entrepreneurship Training Program Project (202310285167Y), and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX22_3221).
Data Sharing Statement: Research data are available at https://www.ncbi.nlm.nih.gov/bioproject/PRJNA992189/ and https://download.cncb.ac.cn/OMIX/OMIX005473/.
Acknowledgments—We extend our gratitude to the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection for their support during this study.
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© 2024 The Author(s). Published by Elsevier Inc.
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