19 september 2011: Bron: Annals of Oncology

Wie dagelijks alcohol gebruikt heeft een beduidend groot risico op het krijgen van darmkanker. Dit blijkt uit een grote meta analyse van beschikbare studies tot 2010. Er wordt geschat dat in 2002 5.1% (mannen) en 1.3% (vrouwen) van alle sterfgevallen aan kanker is veroorzaakt door alcoholgebruik. Alcohol gebruik is niet alleen gelinkt aan darmkanker, maar eigenljik aan bijna alle vormen van kanker. Hier het abstract van de studie maar wie hier klikt kan het volledige studierapport gratis inzien.

A meta-analysis provides strong evidence for an association between alcohol drinking of >1 drink/day and colorectal cancer risk

Alcohol drinking and colorectal cancer risk: an overall and dose–response meta-analysis of published studies

+ Author Affiliations

¹International Agency for Research on Cancer, Lyon, France
²Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan, Italy
³Department of Statistics, University of Milano-Bicocca, Milan, Italy
⁴Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
⁵Department of Clinical Medicine and Prevention, Centre of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Monza, Italy
⁶Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical sciences, Tehran, Iran
⁷King’s College London, Thames Cancer Registry, London, UK
⁸Section of Medical Statistics, Department of Occupational Health, Università degli Studi di Milano, Milan, Italy
⁹The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA
¹⁰International Prevention Research Institute, Lyon, France

↵*Corresponding author: Dr V. Fedirko, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France. Tel: +33-4-72-73-80-32; Fax: +33-4-72-73-83-20; E-mail: fedirkov@fellows.iarc.fr

Received September 9, 2010.
Accepted October 18, 2010.

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Abstract

Background: The International Agency for Research on Cancer (IARC) concluded that alcohol consumption is related to colorectal cancer (CRC). However, several issues remain unresolved, including quantification of the association for light (≤1 drink/day) and moderate (2–3 drinks/day) alcohol drinking, investigation of the dose–response relationship, and potential heterogeneity of effects by sex, colorectal site, and geographical region.

Methods: Twenty-seven cohort and 34 case–control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before May 2010. The summary relative risks (RRs) were estimated by the random effects model. Second-order fractional polynomials and random effects meta-regression models were used for modeling the dose–risk relation.

Results: The RRs were 1.21 [95% confidence interval (CI) 1.13–1.28] for moderate and 1.52 (95% CI 1.27–1.81) for heavy (≥4 drinks/day) alcohol drinking. The RR for moderate drinkers, compared with non-/occasional drinkers, was stronger for men (RR = 1.24, 95% CI 1.13–1.37) than for women (RR = 1.08, 95% CI 1.03–1.13; P_{heterogeneity} = 0.02). For heavy drinkers, the association was stronger in Asian studies (RR = 1.81, 95% CI 1.33–2.46; P_{heterogeneity} = 0.04). The dose–risk analysis estimated RRs of 1.07 (95% CI 1.04–1.10), 1.38 (95% CI 1.28–1.50), and 1.82 (95% CI 1.41–2.35) for 10, 50, and 100 g/day of alcohol, respectively.

Conclusions: This meta-analysis provides strong evidence for an association between alcohol drinking of >1 drink/day and colorectal cancer risk.

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darmkanker, alcohol