13 maart 2023: Zie ook dit artikel: https://kanker-actueel.nl/ivermectine-een-zogeheten-antiparasitair-middel-wormenkuur-blijkt-wel-degelijk-het-coronavirus-covid-19-zeer-goed-te-kunnen-bestrijden-uit-meta-analyse-van-53-studies-blijkt-zeer-grote-effectiviteit.html

13 maart 2023: Op deze website staan alle serieuzere studies uitgevoerd met ivermectine op volgorde van data gepubliceerd. Wie klikt op een vermeldde studie krijgt de belangrijkste uitkomsten en data van betreffende studie. De laatste update is van 10 maart 2023.

13 maart 2023: Bron: Cureus 15 januari 2023

Een grote prospectieve observatiestudie waarbij de inwoners van Itajaí een Braziliaanse stad met 223.128 inwoners allemaal het gebruik van ivermectine is aangeboden en daarna zijn gevolgd en geanalyseerd op het regelmatig gebruik van ivermectine of geen gebruik werden onderzocht in het of verminderen van besmet raken met het coronavirus - Covid-19. Ivermectine werd aangeboden als een optionele behandeling die gedurende twee opeenvolgende dagen om de 15 dagen moest worden ingenomen in een dosis van 0,2 mg/kg/dag

Uit de studie blijkt dat regelmatig gebruik van ivermectine als profylactisch middel gepaard ging met statistisch significant lagere COVID-19-infecties, ziekenhuisopnames en sterftecijfers en geeft aan dat het nemen van 
ivermectine mensen beter beschermd tegen het coronavirus dan geen ivermectine nemen. 

Van de 223.128 inwoners van Itajaí die in aanmerking kwamen voor de studie, werden in totaal 159.561 proefpersonen opgenomen in de analyse: 113.845 (71,3%) regelmatige ivermectinegebruikers en 45.716 (23,3%) niet-gebruikers. Hiervan waren 4.311 ivermectinegebruikers besmet, waarvan 4.197 uit de stad Itajaí (3,7% infectiepercentage), en 3.034 niet-gebruikers (uit Itajaí) waren besmet (6,6% infectiepercentage), met een vermindering van 44% in COVID -19 infectiepercentage (risicoratio , 0,56; 95% betrouwbaarheidsinterval (95% BI), 0,53-0,58; p < 0,0001).

  • Met behulp van de PSM studie werden twee groepen van 3.034 proefpersonen met een COVID-19-infectie vergeleken.
  • Het regelmatige gebruik van ivermectine leidde tot een vermindering van 68% in COVID-19-mortaliteit (25 [0,8%] versus 79 [2,6%] onder niet-gebruikers van ivermectine; RR, 0,32; 95% BI, 0,20-0,49; p < 0,0001) . Gecorrigeerd voor restvariabelen was de verlaging van het sterftecijfer 70% (RR, 0,30; 95% BI, 0,19-0,46; p < 0,0001).
  • Er was een vermindering van 56% in het aantal ziekenhuisopnames (44 versus 99 ziekenhuisopnames bij respectievelijk ivermectinegebruikers en niet-gebruikers; RR, 0,44; 95% CI, 0,31-0,63; p < 0,0001).
  • Na correctie voor resterende variabelen was de vermindering van het aantal ziekenhuisopnames 67% (RR, 0,33; 95% BI, 023-0,66; p < 0,0001).

In een stadsbreed ivermectineprogramma met profylactisch, optioneel gebruik van ivermectine voor COVID-19, werd ivermectine in verband gebracht met statistisch significant lagere COVID-19-infecties, ziekenhuisopnames en sterftecijfers als gevolg van COVID-19.

Hier een van de vele grafieken uit de studie die aangeeft hoe deze studie was opgezet.
Figure 1: Underlying data for the study on ivermectin prophylaxis used for COVID-19.

Het volledige studieverslag is gratis in te zien. Klik de titel van het abstract:

Lucy Kerr • Flavio A. Cadegiani • Fernando Baldi • Raysildo B. Lobo • Washington Luiz O. Assagra • Fernando Carlos Proença • Pierre Kory • Jennifer A. Hibberd • Juan J. Chamie-Quintero

Published: January 15, 2022

DOI: 10.7759/cureus.21272 

Cite this article as: Kerr L, Cadegiani F A, Baldi F, et al. (January 15, 2022) Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching. Cureus 14(1): e21272. doi:10.7759/cureus.21272


Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and COVID-19-related comorbidities. Based on the studies suggesting efficacy in prophylaxis combined with the known safety profile of ivermectin, a citywide prevention program using ivermectin for COVID-19 was implemented in Itajaí, a southern city in Brazil in the state of Santa Catarina. The objective of this study was to evaluate the impact of regular ivermectin use on subsequent COVID-19 infection and mortality rates.

Materials and methods: We analyzed data from a prospective, observational study of the citywide COVID-19 prevention with ivermectin program, which was conducted between July 2020 and December 2020 in Itajaí, Brazil. Study design, institutional review board approval, and analysis of registry data occurred after completion of the program. The program consisted of inviting the entire population of Itajaí to a medical visit to enroll in the program and to compile baseline, personal, demographic, and medical information. In the absence of contraindications, ivermectin was offered as an optional treatment to be taken for two consecutive days every 15 days at a dose of 0.2 mg/kg/day. In cases where a participating citizen of Itajaí became ill with COVID-19, they were recommended not to use ivermectin or any other medication in early outpatient treatment. Clinical outcomes of infection, hospitalization, and death were automatically reported and entered into the registry in real time. Study analysis consisted of comparing ivermectin users with non-users using cohorts of infected patients propensity score-matched by age, sex, and comorbidities. COVID-19 infection and mortality rates were analyzed with and without the use of propensity score matching (PSM).

Results: Of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 subjects were included in the analysis: 113,845 (71.3%) regular ivermectin users and 45,716 (23.3%) non-users. Of these, 4,311 ivermectin users were infected, among which 4,197 were from the city of Itajaí (3.7% infection rate), and 3,034 non-users (from Itajaí) were infected (6.6% infection rate), with a 44% reduction in COVID-19 infection rate (risk ratio , 0.56; 95% confidence interval (95% CI), 0.53-0.58; p < 0.0001). Using PSM, two cohorts of 3,034 subjects suffering from COVID-19 infection were compared. The regular use of ivermectin led to a 68% reduction in COVID-19 mortality (25 [0.8%] versus 79 [2.6%] among ivermectin non-users; RR, 0.32; 95% CI, 0.20-0.49; p < 0.0001). When adjusted for residual variables, reduction in mortality rate was 70% (RR, 0.30; 95% CI, 0.19-0.46; p < 0.0001). There was a 56% reduction in hospitalization rate (44 versus 99 hospitalizations among ivermectin users and non-users, respectively; RR, 0.44; 95% CI, 0.31-0.63; p < 0.0001). After adjustment for residual variables, reduction in hospitalization rate was 67% (RR, 0.33; 95% CI, 023-0.66; p < 0.0001).

Conclusion: In this large PSM study, regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates.

Final discussion

In this citywide ivermectin prophylaxis program, a large, statistically significant decrease in mortality rate was observed after the program began among the entire population of city residents. When comparing subjects that used ivermectin regularly, non-users were two times more likely to die from COVID-19 while ivermectin users were 7% less likely to be infected with SARS-CoV-2 (p = 0.003).

Although this study is not a randomized, double-blind, placebo-controlled clinical trial, the data were prospectively collected and resulted in a massive study sample that allowed adjustment for numerous confounding factors, thus strengthening the findings of the present study.

Due to the well-established, long-term safety profile of ivermectin, with rare adverse effects, the absence of proven therapeutic options to prevent death caused by COVID-19, and lack of effectiveness of vaccines in real-life all-cause mortality analyses to date, we recommend that ivermectin be considered as a preventive strategy, in particular for those at a higher risk of complications from COVID-19 or at higher risk of contracting the illness, not as a substitute for COVID-19 vaccines, but as an additional tool, particularly during periods of high transmission rates.


In a citywide ivermectin program with prophylactic, optional ivermectin use for COVID-19, ivermectin was associated with significantly reduced COVID-19 infection, hospitalization, and death rates from COVID-19.


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