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17 oktober 2020: Zie ook dit artikel: 

https://kanker-actueel.nl/vitamine-c-infusen-met-hoge-dosis-vitamine-c-blijkt-uitstekend-medicijn-bij-patienten-besmet-met-het-corona-virus-covid-19-en-al-met-longontstekingen-blijkt-uit-chinese-studie.html

30 april 2020: lees ook dit artikel: 

https://kanker-actueel.nl/canadese-onderzoekers-verruimen-fase-iii-studie-naar-effecten-van-infusen-met-hoge-dosis-vitamine-c-bij-sepsis-met-opnemen-van-patienten-met-covid-19-in-studieprotocol.html

Update artikel 17 oktober 2020: 

Artikelen over hoge dosis vitamine C bij kanker staan hier op onze website een aantal artikelen: 

https://kanker-actueel.nl/iaa-intraveneuze-injecties-met-vitamine-c-een-overzicht-van-artikelen-en-studies.html

Zie ook in gerelateerde artikelen.  

bv dit artikel:

https://kanker-actueel.nl/vitamine-c-infusen-met-hoge-dosis-vitamine-c-blijkt-uitstekend-medicijn-bij-patienten-besmet-met-het-corona-virus-covid-19-en-al-met-longontstekingen-blijkt-uit-chinese-studie.html

en dit artikel: 

 https://kanker-actueel.nl/infusen-met-hoge-dosis-vitamine-c-verbetert-ademhaling-en-vermindert-de-sterfte-aan-longontstekingen-van-kleine-kinderen-onder-de-5-jaar.html

17 oktober 2020:

De resultaten uit de hier onder beschreven studie zijn te zlen in deze PDF: 

https://assets.researchsquare.com/files/rs-52778/v1/e3812db9-cb32-4a81-b024-76f54c344112.pdf

Samenvattend vonden we dat de toevoeging van Hoge Dosis Intraveneus Vitamine C (HDIVC) een beschermend klinisch effect kan bieden zonder enige bijwerkingen bij ernstig zieke patiënten met COVID-19. HDIVC bood een van de alternatieve behandelingsopties, aangezien er op dit moment geen effectieve medicatie of behandeling was om COVID-19 te genezen. 

Verder zijn afgelopen maanden weer enkele studies gepubliceerd die de effectiviteit van hoge dosis vitamine C en quercetin aantonen. Het is echt teveel om de resultaten te vertalen en er allemaal uit te halen, maar zie o.a. dit studierapport: 

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

(Quercetine en vitamine C: een experimentele, synergetische therapie voor de preventie en behandeling van aan SARS-CoV-2 gerelateerde ziekten (COVID-19))

13 april 2020: 

Prof. Paul Marik, intensivist en internist in het Sentara Norfolk General Hospital in Norfolk in de Amerikaanse staat Virginia gebruikt dit protocol voor patienten die met sepsis in het ziekenhuis belanden. Klik op deze PDF

Uit dit artikel in het Reformatorisch Dagblad een interview met prof. dr. Marik: 

Vitamine C redt levens op ic

De gezondheidstoestand van de 53-jarige Valerie Hobbs was hopeloos. Ze had een ernstige bloedvergiftiging en lag aan de beademing. Nieren en longen werkten niet meer. „Ik ging ervan uit dat ze zou sterven. Bij wijze van experiment gaven we haar vitamine C per infuus. De volgende morgen wist ik niet wat ik zag.”...............

Marik verwachtte niet dat de vitamine C effect zou hebben. „Ik ging die dinsdag naar huis met de gedachte dat ze de volgende dag zou zijn overleden.” Dat gebeurde echter niet. Marik: „Toen ik woensdag op de ic arriveerde, kreeg ze geen bloeddrukverhogende medicijnen meer. Haar bloeddruk was genormaliseerd en de nieren werkten weer. Drie uur later kon ze van de beademing af. Ik was heel verbaasd. Wat was er gebeurd?”

De ic-arts gaf twee nieuwe patiënten dezelfde behandeling. „Weer zagen we hetzelfde gunstige effect”, vertelt Marik in een video op de website van het ziekenhuis.>>>>>>>lees verder

12 april 2020: Bron: Nutraingredients

Over het geven van infusen met hoge dosis vitamine C aan patiënten besmet met het corona virus (COVID-19) en opgenomen in het ziekenhuis of op de IC komen beetje bij beetje meer studies vrij. Een interessante studie is een vorig jaar gepubliceerde meta-analyse van 18 gerandomiseerde studies met totaal 2004 patiënten die de effecten van vitamine C, zowel oraal als per infuus werden gegeven aan patiënten die op de IC waren opgenomen met acute luchtweginfecties.

  • In 12 studies met 1766 patiënten verminderde vitamine C de duur van de IC-opname met gemiddeld 7,8% (95% BI: 4,2% tot 11,2%; p = 0,00003).
  • In zes studies verminderde oraal toegediende vitamine C in doses van 1-3 g / dag (gewogen gemiddelde 2,0 g / dag) de duur van de ICU-verblijf met 8,6% (p = 0,003).
  • In drie studies waarbij patiënten meer dan 24 uur mechanische beademing nodig hadden, verkortte vitamine C de duur van mechanische beademing met 18,2% (95% BI 7,7% tot 27%; p = 0,001).
  • In drie onderzoeken waarbij deelnemers minder dan 24 uur mechanische ventilatie nodig hadden, was er geen bewijs van een effect van vitamine C (p = 0,7).
  • In twee onderzoeken met niet-hartpatiënten [107,117] verkortte vitamine C de duur van mechanische beademing met 27% (95% BI 9% tot 42%; p = 0,006).

Interessant uit de meta-analyse zijn ook de studies met kankerpatiënten en patiënten met aangetoond veel te lage vitamine C waarden die gelijk zijn aan waarden die als scheurbuik worden bestempeld.

Uit een onderzoek onder patiënten met gevorderde kanker in een hospice bleek dat 30% vitamine C-plasmaspiegels had van minder dan 11 μmol / l[86]
In een Canadees universitair ziekenhuis bleek dat 19% van de patiënten vitamine C-plasmaspiegels had van minder dan 11 μmol / [87].
In een onderzoek onder chirurgische patiënten in Australië bleek dat 21% vitamine C-plasmaspiegels had van minder dan 11 μmol / l[89].
Ten slotte had 3% van de kankerpatiënten in een ander onderzoek klinische scheurbuik en vitamine C-plasmaspiegels van minder dan 6 μmol / l[83], en in een onderzoek onder 145 oudere Franse patiënten in het ziekenhuis hadden 18 klinische symptomen van scheurbuik[88]. 

Hoewel deze schattingen van de prevalentie van vitamine C-tekort niet rechtstreeks naar andere ziekenhuisinstellingen mogen worden geëxtrapoleerd, tonen ze aan dat lage vitamine C-spiegels in sommige contexten veel voorkomen.

Daarom lijkt het redelijk om plasma-vitamine C-spiegels bij ziekenhuispatiënten waar nodig te screenen en vitamine C toe te dienen aan patiënten met bijzonder lage spiegels, ongeacht of wordt aangenomen dat vitamine C effectief is voor andere aandoeningen dan scheurbuik.Bovendien zijn er aanwijzingen dat het vitamine C-metabolisme verandert onder veel omstandigheden die fysiologische stress met zich meebrengen, zoals infecties, operaties, trauma's en brandwonden, in welk geval de vitamine C-spiegel dramatisch kan dalen. [90,91,92,93,94,95,96,97,98,99,100,101]

Hoewel 0,1 g / dag vitamine C bij een gezond persoon een normale plasmaspiegel kan handhaven , zijn voor kritisch zieke patiënten veel hogere doses (1-4 g / dag) nodig om de vitamine C-plasmaspiegels in het normale bereik te verhogen [102,103,104,105]. 

Daarom kunnen hoge doses vitamine C nodig zijn om het verhoogde metabolisme te compenseren om normale plasmaspiegels te bereiken.Aangezien vitamine C diverse effecten heeft op medische aandoeningen [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49] is het mogelijk dat in sommige situaties deze effecten ook tot praktische voordelen leiden.

Uit een eerdere meta-analyse van 11 onderzoeken bij patiënten die electieve hartchirurgie ondergingen, bleek dat vitamine C de ziekenhuisopname met gemiddeld 10% verkortte.[28].

Het studierapport: Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis is gratis in te zien.

Een ander interessant artikel is de uitleg hoe vitamine C precies werkt is dit artikel Dietitian's view: Vitamin C and immunity

 By Nikki Hancocks

Vitamin C supplements are flying off the shelves but is there any truth in claims that this could help in the fight against COVID-19 and other respiratory viruses? Independent dietitian Carrie Ruxton explains all.

HTTPS://WWW.NUTRAINGREDIENTS.COM/ARTICLE/2020/04/03/DIETITIAN-S-VIEW-VITAMIN-C-AND-IMMUNITY 

Hier het abstract van de meta analyse met referentielijst:

We found statistically highly significant evidence that vitamin C can shorten the length of ICU stay. We consider that our finding is a proof of concept, strongly encouraging further research, rather than justifying recommendations for change in practice

Vitamin C Can Shorten the Length of Stay in the ICU

A Meta-Analysis by Harri Hemilä 1,*and Elizabeth Chalker 2

1
Department of Public Health, University of Helsinki, POB 41, FI-00014 Helsinki, Finland
2
School of Public Health, University of Sydney, Sydney 2006, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 708; https://doi.org/10.3390/nu11040708
Received: 30 January 2019 / Revised: 12 March 2019 / Accepted: 18 March 2019 / Published: 27 March 2019

Abstract

A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1–3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

References

Supplementary Materials

The following are available online at https://www.mdpi.com/2072-6643/11/4/708/s1, Supplementary file S1 (PDF): Table S1: Descriptions of included trials, Figure S1: Forest plot for all 17 trials for the length of ICU stay; printouts of statistical analyses. Supplementary file S2 (XLSX): spreadsheet showing the extracted data and calculations.

Author Contributions

H.H. planned the study and wrote the first draft. Both authors participated in the selection of studies for the meta-analyses and in extraction of study characteristics and results data. H.H. carried out the statistical analyses. E.C. participated in revision of the manuscript.

Funding

This research received no external funding.

Acknowledgments

No external funding.

Conflicts of Interest

The authors declare no conflict of interest.

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