Artikelen over hoge dosis vitamine C bij kanker staan hier op onze website een aantal artikelen: 

https://kanker-actueel.nl/iaa-intraveneuze-injecties-met-vitamine-c-een-overzicht-van-artikelen-en-studies.html

17 oktober 2020: Afgelopen maanden zijn weer enkele studies gepubliceerd die de effectiviteit van hoge dosis vitamine C en quercetin aantonen. Het is echt teveel om de resultaten te vertalen en er allemaal uit te halen.

Maar is wel interessant, zie bv de resultaten uit een studie (zie in gerelateerde artikelen eerdere beschrijving van deze studie) bij uiteindelijk 58 ernstig zieke coronapatienten:

https://assets.researchsquare.com/files/rs-52778/v1/e3812db9-cb32-4a81-b024-76f54c344112.pdf

Samenvattend vonden we dat de toevoeging van Hoge Dosis Intraveneus Vitamine C (HDIVC) een beschermend klinisch effect kan bieden zonder enige bijwerkingen bij ernstig zieke patiënten met COVID-19. HDIVC bood een van de alternatieve behandelingsopties, aangezien er op dit moment geen effectieve medicatie of behandeling was om COVID-19 te genezen. 

maar zie o.a. ook dit studierapport: 

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

(Quercetine en vitamine C: een experimentele, synergetische therapie voor de preventie en behandeling van aan SARS-CoV-2 gerelateerde ziekten (COVID-19))

Het abstract staat onderaan dit artikel met referentielijst.

Een andere studie is deze: Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19 waarbij een analyse van vitamine C en ook ozontherapie. Download het PDF studierapport voor details van de studie. 

In dit document bespreken we twee eenvoudige adjuvante therapieën om toe te dienen, zonder bijwerkingen en tegen lage kosten die nuttig kunnen zijn voor de behandeling van acute ernstige coronavirusinfectie geassocieerd met acuut respiratoir syndroom (SARS-CoV-2). Vitamine C, een krachtige antioxidant, is naar voren gekomen als een relevante therapie vanwege de potentiële voordelen ervan bij intraveneuze toediening. Het potentiële effect van vitamine C bij het verminderen van ontstekingen in de longen zou een sleutelrol kunnen spelen bij longbeschadiging veroorzaakt door coronavirusinfectie. Een andere mogelijke effectieve therapie is ozon: het is uitgebreid bestudeerd en al vele jaren gebruikt en de doeltreffendheid ervan is tot dusver in veelvoudige studies aangetoond. 

Verschillende gerandomiseerde gecontroleerde studies gericht op het bevestigen van de gunstige effecten van vitamine C en andere supplementen bij ernstig zieke patiënten met sepsis, zijn momenteel aan de gang, waaronder de VICTAS-, ACTS- en HYVCTTSSS-onderzoeken. Zie  studiereferenties: 242526

18 april 2020: Deze studie bij patiënten besmet met het corona virus (COVID-19) loopt al vanaf 11 februari tot 30 september: Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia Resultaten worden eind september 2020 verwacht.

Study Description
Brief Summary:

2019 new coronavirus (2019-nCoV) infected pneumonia, namely severe acute respiratory infection (SARI) has caused global concern and emergency. There is a lack of effective targeted antiviral drugs, and symptomatic supportive treatment is still the current main treatment for SARI.

Vitamin C is significant to human body and plays a role in reducing inflammatory response and preventing common cold. In addtion, a few studies have shown that vitamin C deficiency is related to the increased risk and severity of influenza infections.

We hypothize that Vitamin C infusion can help improve the prognosis of patients with SARI. Therefore, it is necessary to study the clinical efficacy and safety of vitamin C for the clinical management of SARI through randomized controlled trials during the current epidemic of SARI.>>>>>>>lees meer

13 april 2020: Lees ook dit artikel: 

https://kanker-actueel.nl/vitamine-c-gegeven-aan-patienten-met-acute-luchtweginfecties-op-de-intensive-care-vermindert-de-duur-van-de-beademing-met-gemiddeld-18-procent-en-verkort-de-duur-op-de-ic-met-mediaan-8-procent.html

Prof. Paul Marik, intensivist en internist in het Sentara Norfolk General Hospital in Norfolk in de Amerikaanse staat Virginia gebruikt dit protocol van Vitamin C, Hydrocortisone en Thiamine (vitamine B1) voor patienten die met sepsis in het ziekenhuis belanden. Klik op deze PDF

3 april 2020: Hoge doses vitamine C helpen het immuunsysteem te versterken en kunnen (long) ontstekingen remmen en minder erg maken. Maar zie het niet als medicijn tegen het corona virus zelf. Zo stelt dr. Alexander Michels, een onderzoeksmedewerker bij het Linus Pauling Institute in de staat Oregon, die al 20 jaar onderzoek doet hoe vitamine C het lichaam beïnvloedt. Klik op de titel van het artikel:

Does Vitamin C Help Protect You Against COVID-19?

29 maart 2020: Zie via deze link video over hoe infusen met hoge dosis vitamine C kunnen worden toegediend bij patiënten besmet met het corona virus (COVID-19 en in het ziekenhuis terecht komen. Met nog meer informatie erbij. Bv.: 

Here is a verified official statement from China’s Xi’an Jiaotong University Second Hospital:

“On the afternoon of February 20, 2020, another 4 patients with severe coronavirus pneumonia recovered from the C10 West Ward of Tongji Hospital. In the past 8 patients have been discharged from hospital. . . [H]igh-dose vitamin C achieved good results in clinical applications. We believe that for patients with severe neonatal pneumonia, and for critically ill patients, vitamin C treatment should be initiated as soon as possible after admission. Numerous studies have shown that the dose of vitamin C has a lot to do with the effect of treatment. High-dose vitamin C can not only improve antiviral levels, but more importantly, can prevent and treat acute lung injury (ALI) and acute respiratory distress (ARDS).”

Here is a report from Korea:

“At my hospital in Daegu, South Korea, all inpatients and all staff members have been using vitamin C orally since last week. Some people this week had a mild fever, headaches and coughs, and those who had symptoms got 30,000 mg intravenous vitamin C. Some people got better after about two days, and most had symptoms go away after one injection.” (Hyoungjoo Shin, M.D.)>>>>>>>lees verder

25 maart 2020: In New York geven artsen wel infusen met hoge dosis vitamine C. Zie verslag in de Daily mail o.a.: 

New York hospitals are treating coronavirus patients with high dosages of VITAMIN C after promising results from China

Artsen in de staat New York geven hun ernstig zieke coronaviruspatiënten enorme hoeveelheden vitamine C, een tactiek waarvan wordt gezegd dat ze zelfs de zwaarst getroffen mensen in China hebben geholpen.
Dr.Andrew Weber, een longarts in Long Island en specialist op het gebied van intensive care bij Northwell Health, vertelde dat hij zijn intensive care-patiënten onmiddellijk 1.500 milligram intraveneuze vitamine C heeft gegeven.
Die patiënten krijgen vervolgens drie of vier keer per dag de doses van de krachtige antioxidant opnieuw toegediend, legde de arts uit aan de New York Post.

  • Dr Andrew Weber says he has been immediately giving his intensive-care patients 1,500 milligrams of intravenous vitamin C
  • The Long Island-based pulmonologist and critical-care specialist with Northwell Health says patients are given three to four doses a day 
  • The regimen is based on experimental treatments that were done in China
  • Jason Molinet, a spokesman for Northwell, says Vitamin C is being 'widely used' as a coronavirus treatment throughout the health system 
  • A clinical trial into the effectiveness of intravenous vitamin C patients with coronavirus was conducted on February 14 at Zhongnan Hospital in Wuhan 

24 maart 2020: Iemand stuurde mij deze tip voor liposomale vitamine C welke je zelfs zelf kan maken. Maar lees ook onze disclaimer, want we hebben geen enkele band met deze organisatie en geven deze link alleen omdat die wel past in dit onderwerp, maar wij hebben geen enkel belang bij dit artikel. Dus de verantwoording ligt volledig bij de auteur.

Het artikel is al wel in 2017 geschreven dus nog voor de corona crisis. Klik op de volgende link en onderaan staat een recept hoe je deze vorm van vitamine C je ook zelf kunt maken.

Liposomale vitamine C, best opneembare vorm van vitamine C?

22 maart 2020: Dank aan Marcel die dit ons toestuurde: 

Een videoverslag van een conferentie van de Chinese onderzoekers en Europese orthomoleculaire artsen. In het Nederlands:

Originele Engelse verslag staat hier: Successful High-Dose Vitamin C Treatment of Patients with Serious and Critical COVID-19 Infection

19 maart 2020: Hier een officiële studie met hoge dosis vitamine C en het corona virus: Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia

18 maart 2020: Bron: Science of Natural Healing

Vitamine-C infusen met hoge dosis vitamine C blijkt uitstekend te werken bij patiënten die door de besmetting met het corona virus (COBID-19) lichte en ook zware longontstekingen hadden opgelopen. 

Een medisch team van de Xi'an Jiaotong University in China heeft in een Chinees persbericht melding gemaakt van de succesvolle behandeling van coronaviruspatiënten met vitamine C infusen. In dit persbericht beschrijft het team hoe de meeste van de ruim 300 patiënten met ernstige, zogeheten coronaire longontsteking, van potentieel fatale complicaties die door het nieuwe coronavirus COVID-19 waren ontstaan, toch zijn hersteld na behandeling met infusen van hoge doses vitamine-C.

Het medisch team adviseert ook om voor zeer ernstig zieke patiënten en patiënten met ernstige neonatale longontsteking zo snel mogelijk na opname in het ziekenhuis een behandeling met vitamine C te starten.

Vroege toediening van vitamine C roept een sterk antioxidanteffect op, vermindert ontstekingsreacties en de endotheelfunctie kan verbeteren. De onderzoekers beschrijven verder ook hoe tal van onderzoeken hebben aangetoond dat de dosis vitamine C die individueel wordt gebruikt veel te maken heeft met het effect van de behandeling.

Het medische team zegt dat hun ervaring uit het verleden aantoont dat hooggedoseerde vitamine C niet alleen de antivirale niveaus kan verbeteren, maar wat nog belangrijker is, acute longbeschadiging en acute ademnood kan voorkomen en behandelen.

In een perspublicatie (helaas in het Chinees) wordt uitgelegd hoe patiënten die door het coronavirus zijn besmet te behandelen met infusen van hoge dosis vitamine-C.

Op basis van de studie met meer dan 300 patiënten en verder ontwikkeld door 30 experts in de behandeling van longontstekingen veroorzaakt door het nieuwe coronavirus, raden de artsen een hoge dosis vitamine C aan, zelfs voor een lichte infectie door het virus. De in de publicatie aanbevolen dosis is 50 tot 100 mg per kilogram lichaamsgewicht per dag. Voor heel ernstig zieke patiënten wordt tot 200 mg per kilogram lichaamsgewicht per dag geadviseerd, intraveneus geïnjecteerd.

Lees hier een Engelstalige samenvatting van het persbericht van de Chinese onderzoekers

Over vitamine-C infusen heeft het National Cancer Institute van de Amerikaanse regering onlangs een lang artikel gepubliceerd heeft over intraveneuze, hooggedoseerde vitamine C bij de behandeling van kanker.

Zie dit artikel: Intravenous High-Dose Vitamin C in Cancer Therapy Lees dat artikel want is de moeite meer dan waard.

Op basis van de geschiedenis en het gebruik van vitamine C bij de behandeling van kanker, concludeerden de schrijvers dat "het, gezien de huidige hoge financiële kosten van nieuwe kankermedicijnen, rationeel lijkt om de effectiviteit van de huidige therapieën te verbeteren door hun klinische interacties met vitamine C te bestuderen". Ze voegden eraan toe dat volgens hen "de implementatie van dit behandelingsparadigma voordelen zou kunnen opleveren voor veel kankerpatiënten".

Hier de conclusie van de onderzoekers naar vitamine-C bij kankerpatienten.

Concluding Remarks

Vitamin C as a cancer therapy has had a controversial past. What has been intriguing are small clinical trials that suggest some responses, but with no clear rationale for why cancers should respond to vitamin C or a path forward for explaining which patients are most likely to respond.  Now a growing number of preclinical studies are showing how high-dose vitamin C might benefit cancer patients. Importantly, these preclinical studies provide a clear rationale and potential biomarkers that may help personalize the therapeutic approach and identify patient populations that are likely to respond to high-dose vitamin C therapy. Since the mechanisms of action of vitamin C are becoming better defined, we can propose vitamin C combinations in a more rational, hypothesis-driven manner. In addition, given the current high financial cost of new cancer drugs, it seems rational to improve the effectiveness of current therapies by studying their clinical interactions with vitamin C. In our view, the implementation of this treatment paradigm could provide benefit to many cancer patients.

Quercetin displays a broad range of antiviral properties which can interfere at multiple steps of pathogen virulence -virus entry, virus replication, protein assembly- and that these therapeutic effects can be augmented by the co-administration of vitamin C. Furthermore, due to their lack of severe side effects and low-costs, we strongly suggest the combined administration of these two compounds for both the prophylaxis and the early treatment of respiratory tract infections, especially including COVID-19 patients.

. 2020; 11: 1451.
Published online 2020 Jun 19. doi: 10.3389/fimmu.2020.01451
PMCID: PMC7318306
PMID: 32636851

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma.

There are potential limitations of their use in clinical studies. Both agents are present in varying degrees in individuals' diets and global recommendations for vitamin C intake vary extensively across the globe (). Prophylactic interventions in general populations within the community will therefore be confounded by the quantity present in differing diets. Agents such as vitamin C also have well-characterized beneficial effects apart from the antiviral properties we have highlighted here. Supplementation with these agents may therefore promote general health and indirectly affect the capacity of individuals to combat viral infection. Although this would diminish the ability to identify the direct antiviral properties of vitamin C in clinical studies it may have ancillary benefits of promoting general health, which may be particularly pertinent if administered in communities with greater deprivation or from less economically developed countries.

Conclusion

Quercetin displays a broad range of antiviral properties which can interfere at multiple steps of pathogen virulence -virus entry, virus replication, protein assembly- and that these therapeutic effects can be augmented by the co-administration of vitamin C. Furthermore, due to their lack of severe side effects and low-costs, we strongly suggest the combined administration of these two compounds for both the prophylaxis and the early treatment of respiratory tract infections, especially including COVID-19 patients.

Author Contributions

All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Footnotes

Funding. Supported by the CounterACT Program, National Institutes of Health Office of the Director (NIH OD) and the National Institute of Environmental Health Sciences (NIEHS) grant number R21ES030528.

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