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17 augustus 2003: bron: DOW-USA c.q. Celsion

Nieuwe techniek maakt hyperthermie nog effectiever en beter mogelijk als aanvullende toepassing bij het behandelen in combinatie met chemokuren bij borstkanker.

Celsion, een groot Amerikaans bedrijf, gespecialiseerd in medische toepassingen van nieuw technieken maakte deze week bekend dat zij de rechten hebben gekocht van een techniek waarbij hyperthermie nog beter toepasbaar is bij het behandelen van borstkanker met chemokuren. Nadat een fase I studie al had bewezen dat hyperthermie een grotere respons en effect heeft in combinatie of beter als aanvulling met taxol/doxorubicin had de Duke-universiteit een manier gevonden om de hyperthermie nog effectiever te maken. De borsten worden omringd door gedestilleerd water dat zo warm is dat het de borst op kan warmen tot een temperatuur van 42 graden C. zonder risico op verbranden. Hoe hoger de hyperthermie temperatuur hoe groter het effect op het doden van kankercellen. O.i. een prachtige ontwikkeling omdat hyperthermie steeds meer lijkt te bewijzen een prima aanvullende manier van behandelen van kanker te zijn.


-- PRESS RELEASE: Celsion Buys Technology From Duke University COLUMBIA, Md.--(BUSINESS WIRE)--Aug. 7, 2003--

Celsion has obtained exclusive rights to an advanced phased array radio frequency (RF) heating system designed specifically for use with chemotherapeutic drugs for the treatment of locally advanced breast cancer.

Celsion Corporation (AMEX:CLN) today announced that it has obtained exclusive rights to an advanced phased array radio frequency (RF) heating system designed specifically for use with chemotherapeutic drugs for the treatment of breast cancer. Duke engineer, Thaddeus Samulski, Ph.D, developed the technology, which uses RF energy to warm a woman's breast to approximately 42 degrees C to enhance the effectiveness of liposomal chemotherapeutic compounds. During the treatment the breast is immersed in a pool of distilled water, which helps distribute the heat evenly around the breast, thus preventing skin burns and "hot spots," which often create pain. Skin burns and hot spots have, up to now, limited the use of RF hyperthermia as an effective means for treatment of breast cancer. Patients who have undergone the treatment describe their experience as like having their breast immersed in a Jacuzzi(R) (and sometimes refer to the machine as the "booby Jacuzzi").

The breast cancer treatment system is currently being clinically evaluated at Duke. A Phase I trial has been completed and a Phase II trial is underway. The combination of trials was designed to demonstrate the system's ability to enhance the combined therapeutic effect of liposomal encapsulations of doxorubicin plus traditional paclitaxel (Taxol(R)) in the management of locally advanced breast cancer. Results of the Phase I study in 21 women were reported at the 2002 meeting of the American Society of Clinical Oncology (ASCO). The reported results indicated that tumor growth was halted in all women and that 50% of all tumors treated were reduced in size.

In a press release dated May 18, 2002 Duke reported that, "11% of women have had complete pathologic responses, meaning no cancer was found in the breast tissue upon analyzing its surgical remains. 33% of patients had complete clinical responses, meaning visible signs of the tumor could no longer be detected, and 17% of patients were converted from mastectomy candidates to lumpectomy candidates." The lead investigator during the trial was Kimberly Blackwell, M.D. of Duke University Medical Center. The Phase II trial to establish the efficacy of the system, also under Dr. Blackwell's direction, is ongoing.

Celsion and the Duke medical team believe that this technology will provide the ideal heat source for Thermodox(TM), Celsion's heat-activated liposomal encapsulation of doxorubicin, which is released from the liposome at 40-41 degrees C. Celsion has also licensed its heat activated liposome technology from Duke University. "As an established, successful partner with Duke University and a leader in the field of focused heating, Celsion was the ideal candidate to develop this technology," said inventor, Thaddeus Samulski. "I look forward to working with the team at Celsion and expanding the clinical trials to include the thermal sensitive liposomes developed by my Duke colleagues, Dr. David Needham and Dr. Mark Dewhirst."
Celsion believes that Dr. Samulski's system will complement the adaptive phased array technology it has licensed from the Massachusetts Institute of Technology, which is currently in pivotal Phase II trials to treat both early and advanced stage breast cancer.

Dr. Augustine Cheung, Celsion's founder, Chief Executive Officer and Chief Scientific Officer added, "We are very excited to have acquired this technology, which has already shown great promise with non-temperature-sensitive liposomal chemotherapeutic drugs. Used in conjunction with our temperature-sensitive liposomes, we believe it has the potential to be even more effective. With the addition of Dr. Samulski's technology we now have heating technologies that will enable us to test Thermodox(TM) on three major cancers--prostate, breast and liver. We also believe that future adaptations of this technology could be used to heat other deep seated tumor sites to enable activation of other temperature-sensitive pharmaceutical and genetic therapies currently being developed by Celsion."

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