12 november 2018: lees ook dit artikel: 

https://kanker-actueel.nl/genentest-oncotype-dx-bij-patienten-met-hormoongevoelige-borstkanker-er-pos-her2-neg-heeft-een-directe-relatie-met-wel-of-geen-chemo-en-risico-op-overlijden-en-zou-standaard-ingevoerd-moeten-worden.html

28 september 2018: lees het advies van het Zorginstituut om de mammaprint uit de basisverzekering te halen. 

5 juni 2018: Bron: NEJM, June 3, 2018

Het definitieve studierapport: Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer is deze week gepubliceerd in NEJM en is volledig gratis in te lezen of te downloaden.

Met als conclusie dat alleen hormoontherapie een gelijke overall overleving op 10 jaar geeft dan chemo plus hormoontherapie. De mammaprint kan voorspellen welke vrouwen wel en welke vrouwen geen chemo nodig zouden hebben.

Conclusions

Adjuvant endocrine therapy and chemoendocrine therapy had similar efficacy in women with hormone-receptor–positive, HER2-negative, axillary node–negative breast cancer who had a midrange 21-gene recurrence score, although some benefit of chemotherapy was found in some women 50 years of age or younger. (Funded by the National Cancer Institute and others; TAILORx ClinicalTrials.gov number, NCT00310180.)

Zie verder alles over de mammaprint hieronder en in gerelateerde artikelen.

29 maart 2017: Bron: DOI: 10.1200/JCO.2016.70.3959 Journal of Clinical Oncology - published online before print March 13, 2017

Dat ook vrouwen met hormoongevoelige borstkanker een mammaprint absoluut nodig hebben blijkt uit een nieuwe Nederlandse studie onder 660 patiënten in 33 verschillende ziekenhuizen in de periode oktober 2013 t/m december 2015. Maar liefst 51 procent kreeg na een mammaprint met de 70 genentest van de mammaprint een ander behandelplan voorgesteld dan wat de oncoloog had voorgesteld op basis van de CT-scans enz. voordat er een mammaprint werd gemaakt. En dan te bedenken dat nog maar de helft van de vrouwen met borstkanker deze mammaprint krijgen. vaak nog op eigen verzoek.

mammaprint studie grafiek

Hier de conclusie in het Engels uit het studierapport

Between October 1, 2013, and December 31, 2015, 660 patients, treated in 33 hospitals, were enrolled. Fifty-one percent of patients had pT1cN0, BRII, HER2-Neu-negative breast cancer. On the basis of conventional clinicopathological characteristics, physicians recommended CT in 270 (41%) of the 660 patients and recommended withholding CT in 107 (16%) of the 660 patients. For the remaining 43% of patients, the physicians were unsure and unable to give advice before 70-GS testing. In patients for whom CT was initially recommended or not recommended, 56% and 59%, respectively, were assigned to a low-risk profile by the 70-GS (κ, 0.02; 95% CI, -0.08 to 0.11). After disclosure of the 70-GS test result, the preliminary advice was changed in 51% of patients who received a recommendation before testing; the definitive CT recommendation of the physician was in line with the 70-GS result in 96% of patients.

mammaprint studie

Het volledige studierapport: Impact of 70-Gene Signature Use on Adjuvant Chemotherapy Decisions in Patients With Estrogen Receptor–Positive Early Breast Cancer: Results of a Prospective Cohort Study is gratis in te zien.

Hier het abstract van de studie:

use of the MammaPrint 70-gene signature (70-GS) test changed physician-intended recommendations to administer adjuvant chemotherapy in half of patients with early-stage estrogen receptor–positive breast cancer

DOI: 10.1200/JCO.2016.70.3959 Journal of Clinical Oncology - published online before print March 13, 2017

Impact of 70-Gene Signature Use on Adjuvant Chemotherapy Decisions in Patients With Estrogen Receptor–Positive Early Breast Cancer: Results of a Prospective Cohort Study

, , , , , , , , , , and
Anne Kuijer, Marieke Straver, Bianca den Dekker, Annelotte C.M. van Bommel, and Thijs van Dalen, Diakonessenhuis; Anne Kuijer, Sjoerd G. Elias, Sabine C. Linn, and Thijs van Dalen, University Medical Centre Utrecht; Sabine Siesling, Netherlands Comprehensive Cancer Organization, Utrecht; Carolien H. Smorenburg and Jelle Wesseling, Antoni van Leeuwenhoek Hospital; Carolien H. Smorenburg, Jelle Wesseling, Sabine C. Linn, and Emiel J.Th. Rutgers, Netherlands Cancer Institute, Amsterdam; and Sabine Siesling, University of Twente, Enschede, the Netherlands.

Abstract

Gene-expression profiles increasingly are used in addition to conventional prognostic factors to guide adjuvant chemotherapy (CT) decisions. The Dutch guideline suggests use of validated gene-expression profiles in patients with estrogen receptor (ER) –positive, early-stage breast cancer without overt lymph node metastases. We aimed to assess the impact of a 70-gene signature (70-GS) test on CT decisions in patients with ER-positive, early-stage breast cancer.

In a prospective, observational, multicenter study in patients younger than 70 years old who had undergone surgery for ER-positive, early-stage breast cancer, physicians were asked whether they intended to administer adjuvant CT before deployment of the 70-GS test and after the test result was available.

Between October 1, 2013, and December 31, 2015, 660 patients, treated in 33 hospitals, were enrolled. Fifty-one percent of patients had pT1cN0, BRII, HER2-Neu-negative breast cancer. On the basis of conventional clinicopathological characteristics, physicians recommended CT in 270 (41%) of the 660 patients and recommended withholding CT in 107 (16%) of the 660 patients. For the remaining 43% of patients, the physicians were unsure and unable to give advice before 70-GS testing. In patients for whom CT was initially recommended or not recommended, 56% and 59%, respectively, were assigned to a low-risk profile by the 70-GS (κ, 0.02; 95% CI, -0.08 to 0.11). After disclosure of the 70-GS test result, the preliminary advice was changed in 51% of patients who received a recommendation before testing; the definitive CT recommendation of the physician was in line with the 70-GS result in 96% of patients.

In this prospective, multicenter study in a selection of patients with ER-positive, early-stage breast cancer, 70-GS use changed the physician-intended recommendation to administer CT in half of the patients.

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