14 februari 2022:  2021; 2021: 1075513. Published online 2021 Oct 25.

Uit een gerandomiseerde fase II studie bij totaal 220 patiënten (in elke groep 110 patiënten) met gevorderde eierstokkanker (stadium III en IV) blijkt dat het effect van psychologische interventie in combinatie met voedingsrichtlijnen op kwaliteit van leven en overleving van een TCM aanpak het zogeheten Bushen Quyu-afkooksel (thee) bij de behandeling van deze patiënten hele goede resultaten laat zien. Op een 2-jaars meting was het verschil in overleving maar liefst 23 procent beter voor de studiegroep in vergelijking met de controlegroep. Overall verdubbelde het effect van de totale aanpak van 31 naar 64 procent. Met maar liefst 14 volledige remissies en 57 gedeeltelijke remissies.

Met als conclusie: Samenvattend kan het Bushen Quyu-afkooksel in combinatie met psychologische interventie en dieetbegeleiding voor de behandeling van patiënten met gevorderde eierstokkanker de negatieve emoties van de patiënt effectief verlichten, de immuunfunctie van de patiënt verbeteren, het niveau van tumormarkers verlagen en de kwaliteit van leven van de patiënt verder verbeteren en verpleegkundige tevredenheid, verbetering van het behandelingseffect en bevordering van de revalidatie van patiënten; het is een klinische toepassing waard.

Vertaald uit het studierapport zijn dit de resultaten:

  • Het totale effectieve behandelingspercentage in de observatiegroep (64,55%) was hoger dan die in de controlegroep (31,82%).
  • De verpleegkundige tevredenheid van de observatiegroep was 94,55%, de verpleegkundige tevredenheid van de controlegroep was 84,55% en het verschil was statistisch significant (p <0,01).
  • De therapietrouw van de observatiegroep was 98,18%, de therapietrouw van de controlegroep was 82,73% en het verschil was statistisch significant (p < 0,0001).
  • Na de verpleging waren de angst-zelfbeoordelingsschaal (SAS)-score en de zelfbeoordelingsdepressieschaal (SDS)-score van de twee groepen patiënten verlaagd (∗p <0,05), en de score van de observatiegroep significanter verlaagd (Δp < 0,05).
  • Na verpleging namen de scores van de twee groepen patiënten in sociale/familiale status, fysiek functioneren, fysiologisch functioneren en emotionele status toe (∗p <0,05), en de observatiegroep was significant hoger dan de controlegroep (Δp <0,05) .
  • Na verpleging waren de CD3+, CD4+, CD4+/CD8+ niveaus van de observatiegroep significant hoger dan de controlegroep (p < 0,05). Het CD8+-niveau van de observatiegroep was significant lager dan de controlegroep (p < 0,05).
  • Na borstvoeding waren de niveaus van tumormarkers in de twee groepen verlaagd (∗p <0,05), en de observatiegroep was significant meer gedownreguleerd dan de controlegroep (Δp <0,05).
  • Het cumulatieve overlevingspercentage van twee jaar van de observatiegroep was 78,18% en het cumulatieve overlevingspercentage van twee jaar van de controlegroep was 54,55%. De observatiegroep was significant hoger dan de controlegroep (p <0,05).
Het volledige studierapport dat gedetailleerd beschrijft hoe de studie werd uitgevoerd enz. is gratis in te zien. Klik daarvoor op de titel van het abstract:

Abstract

Objective

To study the effects of psychological intervention combined with dietary guidance on the quality of life and long-term efficacy of Bushen Quyu Decoction in the treatment of patients with advanced ovarian cancer.

Methods

220 patients with advanced (stages III to IV) ovarian cancer in our hospital from May 2015 to October 2018 were selected and randomly divided into a control group and an observation group, with 110 cases in each group. The patients in the control group received basic nursing care and treatment with Bushen Quyu Decoction, and the patients in the observation group were combined with psychological intervention and dietary guidance on the basis of the treatment of the patients in the control group. The clinical efficacy, nursing satisfaction, treatment compliance, quality of life, negative emotion comparison, and long-term efficacy of the two groups were compared. Moreover, the changes of immune function indexes and the content of tumor markers were compared between the two groups.

Results

The total effective rate of treatment in the observation group (64.55%) was higher than that in the control group (31.82%). The nursing satisfaction of the observation group was 94.55%, the nursing satisfaction of the control group was 84.55%, and the difference was statistically significant (p < 0.01). The treatment compliance of the observation group was 98.18%, the treatment compliance of the control group was 82.73%, and the difference was statistically significant (p < 0.0001). After nursing, the Anxiety Self-Rating Scale (SAS) score and Self-Rating Depression Scale (SDS) score of the two groups of patients were decreased (∗p < 0.05), and the score of the observation group decreased more significantly (Δp < 0.05). After nursing, the scores of the two groups of patients in social/family status, physical function, physiological function, and emotional status increased (∗p < 0.05), and the observation group was significantly higher than the control group (Δp < 0.05). After nursing, the CD3+, CD4+, CD4+/CD8+ levels of the observation group were significantly higher than the control group (p < 0.05). The CD8+ level of the observation group was significantly lower than the control group (p < 0.05). After nursing, the levels of tumor markers in the two groups were decreased (∗p < 0.05), and the observation group was downregulated more significantly than the control group (Δp < 0.05). The two-year cumulative survival rate of the observation group was 78.18%, and the two-year cumulative survival rate of the control group was 54.55%. The observation group was significantly higher than the control group (p < 0.05).

Conclusions

Psychological intervention combined with dietary guidance can significantly improve the quality of life and mental state of patients with advanced ovarian cancer, enhance the patient's immune function, reduce the serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen (CA199) levels, and improve survival rate and survival time, which has important clinical significance.

Acknowledgments

The authors deeply appreciate the contributions to this work made in various ways by all of the participants.

Data Availability

The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.

Disclosure

The funding body had no role in the design of the study, collection, analysis, interpretation of data, or writing of the manuscript.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

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