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Zie hier een aantal artikelen met vitamine D in de titel: https://kanker-actueel.nl/NL/search.html?search_text=vitamine%20D&search_in=title&page=9

4 oktober 2026: Bron: 2026 Feb;27(1):78-84

Een vitamine D tekort kan leiden tot meer en ernstigere wondinfecties na een operatie en patiënten met een vitamine D tekort hebben langere tijd nodig voor volledige wonddichting en herstel van de operatie. Dat blijkt uit een meta-analyse van 8 studies met totaal 12.737 mensen die een operatie moesten ondergaan en een aantoonbaar vitamine D tekort hadden. 

Deze meta-analyse omvatte 12.737 patiënten uit acht geschikte studies. De overkoepelende analyse, gebaseerd op afkapwaarden voor vitamine D, toonde aan dat een vitamine D-tekort (<20 ng/ml) gepaard gaat met een verhoogde kans op wondinfecties na operatie. Opvallend is dat een afkapwaarde van <30 ng/ml verband houdt met een nog grotere kans op wondinfecties na operatie. (OR: 3,84; 95%-BI: 2,13-5,56; I² = 0,0%; p = 0,83).

Al eerder in 2015 werd in een andere meta-analyse dezelfde resultaten gevonden. De belangrijkste bevinding van dat literatuuroverzicht is dat 26 van de 31 studies (84%) melding maken van ten minste één statistisch significant slechtere uitkomst bij patiënten met een lage vitamine D-status. Vijf van de 31 studies (16%) vonden geen verband.

Concluderend ondersteunt dit overzicht de hypothese dat een vitamine D-tekort verband houdt met ongunstige uitkomsten na uiteenlopende chirurgische ingrepen. Maar ook toen en nu weer worden nieuwe studies gevraagd voor beter bewijs. Hoeveel bewijs moet er eigenlijk zijn?

Wellicht als u een operatie moet ondergaan het beter is om uw vitamine D waarden eerst te meten via de huisarts. Dat is eenvoudig en goedkoop. En bij een vitamine D tekort is het wellicht verstandig eerst via voedingssupplementen uw vitamine D tekort aan te vullen voordat de operatie plaatsvindt. Mocht dat kunnen wat betreft tijd uiteraard.

Hier de twee abstracten waarvan alleen de meta-analyse uit 2015 volledig gratis is te lezen of te downloaden. De meta-analyse uit 2026 is alleen onder bepaalde voorwaarden gratis in te zien of te downloaden.

Abstract

Background/objectives: Surgical site infection (SSI) places a burden on the healthcare system and patients. Literature suggests that vitamin D has indirect antimicrobial effects and an association with a reduction in infections. We aim to evaluate the association between vitamin D deficiency in developing SSIs in adult surgical patients.

Methods: Embase, Medline, Clinicaltrials.gov, WHO-ICTRP, Cochrane, Web of Science, CINAHL, Google Scholar, Cochrane Central Register of Controlled Trials, and Citations were searched. Observational studies that evaluated key question were included. The meta-analysis was carried out using bias-adjusted inverse variance heterogeneity methods. A risk of bias assessment was done using the MASTER Scale. The Doi plot and the Luis Furuya-Kanamori index were utilized to visualize and quantify the asymmetry of study effects, respectively, to evaluate publication bias. The GRADE method was utilized for assessing the certainty of evidence.

Results: This meta-analysis included 12,737 patients from eight eligible cohort studies. The overall analysis based on vitamin D cut-off levels revealed that vitamin D deficiency (<20 ng/mL) is associated with increased odds of SSI (odds ratio : 1.42, 95% confidence interval : 0.80-2.05; I2 = 37.2%, p = 0.18). Notably, a cut-off level of <30 ng/mL is linked to even higher odds of SSI (OR: 3.84, 95% CI: 2.13-5.56; I2 = 0.0%, p = 0.83).

Conclusion: This meta-analysis found a significant association between vitamin D deficiency and an increased risk of SSI. Taken together, these studies suggest that vitamin D deficiency may play a role in SSI development. However, in order to determine if vitamin D supplementation alone will reduce the risk of a post-operative SSI, a prospective clinical trial is necessary.

De studie uit 2015:

Vitamin D status and surgical outcomes: a systematic review

1, 2,✉
PMCID: PMC4413543  PMID: 25926889

Abstract

The importance of vitamin D for musculoskeletal health has long been recognized, and awareness of significant extra-skeletal effects in health and disease is rapidly emerging. Although it has been possible for many decades to quantify serum markers of vitamin D deficiency, and to correct deficiency at low cost and with high safety, the influence of vitamin D status on post-surgical outcomes has only recently been identified as a research topic of interest. To the present, these data have not been the subject matter of formal review. Accordingly, we conducted a systematic review to assess the association between perioperative vitamin D status and outcomes after surgery. The databases of PubMed, Ovid MEDLINE, EMBASE, AMED, CINAHL (EBSCOHost), The Cochrane Databases of Systematic Review, and PROSPERO were searched through December, 2014 for studies relating to vitamin D and surgery. The initial search yielded 90 manuscripts. After applying exclusion criteria, 31 studies were eligible for inclusion. Fifteen studies employed prospective observational designs, 3 used prospective randomized protocols, and 13 report retrospective database interrogations. The main finding of the present review is that 26 of 31 studies (84%) report at least one statistically significant worse outcome in patients with low vitamin D status. Five of 31 studies (16%) found no association. In conclusion, this review supports the hypothesis that hypovitaminosis D is associated with adverse outcomes after diverse surgical procedures. Future studies should focus on additional surgeries and outcomes, and on the role of vitamin D supplementation in the improvement of patient safety in participants with low vitamin D status at the time of surgery.


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Data availability statement

The original contributions presented in this study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author.

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Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

Vitamine D, wondinfecties, wondherstel, operaties, meta-analyse, Vitamine D tekort


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