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27 oktober 2008: Bron: 1: Klin Padiatr. 2008 Nov-Dec;220(6):365-70. Epub 2008 Oct 23. Links

 

Nieuwe gerandomiseerde studie bewijst opnieuw de waarde van acupunctuur bij het verminderen van misselijkheid en overgeven bij chemo gegeven aan kinderen. Hier het abstract van de nieuwste studie, daaronder een soortgelijke studie met dezelfde goede resultaten daaronder uit 2005

Acupuncture to Alleviate Chemotherapy-induced Nausea and Vomiting in Pediatric Oncology - A Randomized Multicenter Crossover Pilot Trial.

1Department of Pediatric Hematology and Oncology, Saarland University, Homburg, Germany.

BACKGROUND: We investigated whether acupuncture as a supportive antiemetic approach reduces the need for antiemetic rescue medication during highly emetogenic chemotherapy in pediatric oncology. We report on a multicenter crossover study at 5 tertiary hospitals in Germany.

PROCEDURE: Twenty-three children (13.6 y,+/- 2.9) receiving highly emetogenic chemotherapy for treatment of solid malignant tumors were included. Patients were randomly allocated to receive acupuncture treatment during either the second or third identical chemotherapy course together with standard antiemetic medication. The main outcome measure was the amount of additional antiemetic medication during chemotherapy. Secondary outcome measure was the number of episodes of vomiting per course.

RESULTS: Fourty-six chemotherapy courses with or without acupuncture were compared. The need for rescue antiemetic medication was significantly lower in acupuncture courses compared to control courses (p=0.001) Episodes of vomiting per course were also significantly lower in courses with acupuncture (p=0.01). Except for pain from needling (4/23) no side effects occurred. Patients acceptance of acupuncture was high.

CONCLUSIONS: Acupuncture as applied here seems to be effective in preventing nausea and vomiting in pediatric cancer patients.

PMID: 18949672 [PubMed - in process]

13 juli 2006: Reindl TK et al ; Support Care Cancer 2005 Jul 14: met dank aan Frank

Acupunctuur reduceert in gerandomiseerd cross-over onderzoek bij kinderen de bijwerkingen van chemo.

RESULTATEN: Tweeëntwintig kuren met of zonder acupunctuur werden vergeleken. De voordelen van acupunctuur in adolescenten met betrekking tot de vermindering van extra antiemetic medicijn werden waargenomen. Acupunctuur liet patiënten toe om hogere niveaus van waakzaamheid tijdens chemotherapie te ervaren en verminderde misselijkheid en het braken. Behalve naaldpijn, werden geen bijwerkingen genoteerd. Er was hoge acceptatie van acupunctuur door de patiënten. De gegevens wijzen erop dat de acupunctuur antiemetic medicijn en episoden van het braken zou kunnen verminderen bj kinderen met kanker.

Acupuncture against chemotherapy-induced nausea and vomiting in pediatric oncology Interim results of a multicenter crossover study.

Support Care Cancer, 2005 Jul 14

Reindl TK, Geilen W, Hartmann R, Wiebelitz KR, Kan G, Wilhelm I, Lugauer S, Behrens C, Weiberlenn T, Hasan C, Gottschling S, Wild-Bergner T, Henze G, Driever PH

GOALS: In this multicenter crossover study, our aim was to evaluate the efficacy and acceptance of acupuncture as a supportive antiemetic approach during highly emetogenic chemotherapy in pediatric oncology.

PATIENTS AND METHODS: Eleven children receiving several courses of highly emetogenic chemotherapy for treatment of solid tumors were included. Randomization allocated patients to start chemotherapy either with antiemetic medication plus acupuncture or antiemetic medication alone. During all study courses, patients continued to receive their programmed and additional antiemetic edication as needed. Acupuncture was given at day 1 of chemotherapy and at subsequent days on patient's demand. The amount of baseline and additional antiemetic medication during chemotherapy was documented. Patients maintained a daily diary of vomiting episodes and completed an evaluated nausea score at the end of every course. Their body weight was taken before and after a chemotherapy course.

MAIN RESULTS: Twenty-two courses with or without acupuncture were compared. The benefits of acupuncture in adolescents with respect to the reduction of additional antiemetic medication were observed. Acupuncture enabled patients to experience higher levels of alertness during chemotherapy and reduced nausea and vomiting. Except for needle pain, no side effects were noted. Patient's acceptance of acupuncture was high.

CONCLUSION: Our data indicate that acupuncture might reduce antiemetic medication and episodes of vomiting in pediatric oncology.

[PMID: 16021478 [PumMed - Publisher]


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