19 januari 2023: Bron:  2022; 2022: 6587884. Published online 2022 Jul 21

Acupunctuur via moxibustion (verwarming van bepaalde acupunctuurpunten), voorkomt beter bij patiënten met gevorderde darmkanker dat een chemokuur met irinotecan diarree veroorzaakt dan zonder moxibustion. Moxibustion was effectiever in het voorkomen van geïnduceerde vertraagde diarree (IIDD), wat de incidentie en ernst van IIDD zou kunnen verminderen, de duur van diarree zou kunnen verkorten en de kwaliteit van leven van patiënten aanzienlijk zou kunnen verhogen zonder significante nadelige effecten.  

Dat blijkt uit een gerandomiseerde studie bij totaal 120 patiënten (N = 60 vs 60) met gevorderde uitgezaaide darmkanker die FOLFIRI kregen als chemo.

Uit het abstract vertaald in het Nederlands:

Resultaten:

  • De incidentie van graad 1, 2, 3 en 4 diarree in de onderzoeksgroep was 11,67% (7/60), 5,00% (3/60), 3,33% (2/60) en 0,00% (0/60). 60), terwijl de incidentie van graad 1, 2, 3 en 4 diarree in de controlegroep 21,67% (13/60), 8,33% (5/60), 10,00% (6/60) en 3,33 was.
  • De incidentie van ernstige diarree en totale diarree in de onderzoeksgroep was (3,33% en 20,00%) lager dan die in de controlegroep (13,33% en 43,33%) (P < 0,05).
  • De incidentie van uitgestelde chemotherapie was lager in de onderzoeksgroep (8,33%) (1/12) dan in de controlegroep (23,08%) (6/26), maar het verschil tussen de groepen was niet statistisch significant (P > 0,05).
  • De tijd tot aanvang van geïnduceerde vertraagde diarree (IIDD) in de onderzoeksgroep (6,45 ± 1,53) dagen was vergelijkbaar met die in de controlegroep (6,40 ± 1,77 dagen) (P > 0,05), maar de duur van IIDD in de onderzoeksgroep (3,25 ± 1,05 dagen ) was korter dan die in de controlegroep (5,70 ± 1,72 dagen) (P < 0,05).
  • Na behandeling was de incidentie van KPS-verbetering, stabilisatie en reductie in de onderzoeksgroep respectievelijk 38,33% (23/60), 51,67% (31/60) en 10,00% (6/60), de incidentie van KPS-verbetering , stabilisatie en reductie in de controlegroep was respectievelijk 23,33% (14/60), 50,00% (30/60) en 26,67% (16/60), en het percentage KPS-reductie in de onderzoeksgroep was minder dan dat in de controlegroep (P < 0,05).
  • Tijdens de observatieperiode na de behandeling was de totale incidentie van leukopenie in de onderzoeksgroep 11,67% (7/60), wat lager is dan 31,67% (19/60) in de controlegroep (P < 0,05).
  • Tijdens de observatieperiode na de behandeling was de incidentie van III°+°IV myelosuppressie in de onderzoeksgroep 5,00% (3/60), wat lager is dan 25,00% (15/60) in de controlegroep (P < 0,05).

Het volledige studierapport is gratis in te zien. Klik op de titel van het abstract:

 2022; 2022: 6587884.
Published online 2022 Jul 21. doi: 10.1155/2022/6587884
PMCID: PMC9334062
PMID: 35912389

Clinical Study on Prevention of Irinotecan-Induced Delayed-Onset Diarrhea by Hot Ironing with Moxa Salt Packet on Tianshu and Shangjuxu

Xianghong Lai and Anmei Wangcorresponding author
Author information Article notes Copyright and License information Disclaimer

Abstract

Objective

To study the clinical efficacy of hot ironing of the Tianshu and Shangjuxu with moxa salt packet to prevent irinotecan (CPT-11)-induced delayed-onset diarrhea (IIDD).

Methods

A randomized controlled study was conducted on a sample of 120 patients with advanced colorectal cancer who were hospitalized in our oncology department and treated with FOLFIRI chemotherapy regimen from February 2018 to July 2021. They were equally divided into study group (n = 60) and control group (n = 60) according to whether they were treated with hot ironing with moxa salt packs or not. The general conditions, occurrence of IIDD, occurrence of delayed chemotherapy due to IIDD, time of occurrence and duration of IIDD, Karnofsky performance score (KPS) score, occurrence of leukopenia, and myelosuppression were compared between the two groups.

Result

The incidence of grade 1, 2, 3, and 4 diarrhea in the study group was 11.67% (7/60), 5.00% (3/60), 3.33% (2/60), and 0.00% (0/60), respectively, while the incidence of grade 1, 2, 3, and 4 diarrhea in the control group was 21.67% (13/60), 8.33% (5/60), 10.00% (6/60), and 3.33% (2/60). The incidence of severe diarrhea and total diarrhea in the study group was (3.33% and 20.00%) lower than that in the control group (13.33% and 43.33%) (P < 0.05). The incidence of delayed chemotherapy was lower in the study group (8.33%) (1/12) than in the control group (23.08%) (6/26) but the difference between the groups was not statistically significant (P > 0.05). The time to onset of IIDD in the study group (6.45 ± 1.53) days was comparable to that in the control group (6.40 ± 1.77 days) (P > 0.05), but the duration of IIDD in the study group (3.25 ± 1.05 days) was shorter than that in the control group (5.70 ± 1.72 days) (P < 0.05). After treatment, the incidence of KPS improvement, stabilization, and reduction in the study group was 38.33% (23/60), 51.67% (31/60), and 10.00% (6/60), respectively, the incidence of KPS improvement, stabilization, and reduction in the control group was 23.33% (14/60), 50.00% (30/60), and 26.67% (16/60), respectively, and the percentage of KPS reduction in the study group was less than that in the control group (P < 0.05). During the observation period after treatment, the total incidence of leucopenia in the study group was 11.67% (7/60) which is lower than 31.67% (19/60) in the control group (P < 0.05). During the observation period after treatment, the incidence of III°+°IV myelosuppression in the study group was 5.00% (3/60) which is lower than 25.00% (15/60) in the control group (P < 0.05).

Conclusion

The hot ironing with moxa salt packet on Tianshu and Shangjuxu was more effective in preventing IIDD, which could reduce the incidence and severity of IIDD, shorten the duration of diarrhea and significantly increase the quality of life of patients with no significant adverse effects.

Conflict of interest statement

The authors declare no conflicts of interest.

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