15 juni 2005: Bron: The Lancet. 2002 May 25;359(9320):1812-8.

Wanneer darmkankerpatiënten direct na een operatie zout en water krjgen toegediend met als doel de ontlasting weer op gang te brengen gebeurt juist het tegenovergestelde. De ontlasting komt later op gang en de duur van verblijf in het ziekenhuis wordt maar leifst met drie dagen = 50% verlengt, een hoog significant verschil. Dit alles blijkt uit een gerandomiseerde studie, al in 2002 gepubliceerd in The Lancet.

Comment in:
Lancet. 2002 May 25;359(9320):1792-3.
Lancet. 2002 Nov 23;360(9346):1699; author reply 1699-700.
Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial.

Lobo DN, Bostock KA, Neal KR, Perkins AC, Rowlands BJ, Allison SP.
Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK. dileep.lobo@nottingham.ac.uk

BACKGROUND: Low concentrations of albumin in serum and long gastric emptying times have been returned to normal in dogs by salt and water restriction, or a high protein intake. We aimed to determine the effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection in human beings.

METHODS: We randomly allocated ten patients to receive postoperative intravenous fluids in accordance present hospital practice (> or = 3 L water and 154 mmol sodium per day) and ten to receive a restricted intake (< or = 2 L water and 77 mmol sodium per day). All patients had no disease other than colonic cancer. The primary endpoint was solid and liquid-phase gastric emptying time, measured by dual isotope radionuclide scintigraphy on the fourth postoperative day. Secondary endpoints included time to first bowel movement and length of postoperative hospital stay. Analysis was by intention to treat.

FINDINGS: Median solid and liquid phase gastric emptying times (T(50)) on the fourth postoperative day were significantly longer in the standard group than in the restricted group (175 vs 72.5 min, difference 56 [95% CI 12-132], p=0.028; and 110 vs 73.5 min, 52 [9-95], p=0.017, respectively). Median passage of flatus was 1 day later (4 vs 3 days, 2 [1-2], p=0.001); median passage of stool 2.5 days later (6.5 vs 4 days, 3 [2-4], p=0.001); and median postoperative hospital stay 3 days longer (9 vs 6 days, 3 [1-8], p=0.001) in the standard group than in the restricted group. One patient in the restricted group developed hypokalaemia, whereas seven patients in the standard group had side-effects or complications (p=0.01).

INTERPRETATION: Positive salt and water balance sufficient to cause a 3 kg weight gain after surgery delays return of gastrointestinal function and prolongs hospital stay in patients undergoing elective colonic resection.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 12044376 [PubMed - indexed for MEDLINE]

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