3 juli 2013: Ik heb onderaan een overzichtstudie toegevoegd over huidige situatie van immuuntherapie bij baarmoederhalskanker die ook informatie geeft over onderstaande behandeling. Het volledige studierapport: Immunotherapy for Cervical Cancer: Research Status and Clinical Potential is gratis in te zien. Onderaan artikel staat abstract met referentielijst.

18 juli 2012: Bron: LUMC - Leiden  

Een bezoekster van onze site wees me op een lopende studie in het LUMC met het vaccin tegen het HPV virus bij reeds bestaande en uitgezaaide baarmoederhalskanker. In 2009 schreef de Volkskrant daarover al een artikel, zie onderaan en hier een kort bericht over deze studie in het LUMC. Informatie kunt u verkrijgen over deze studie bij:  Mw. M.J.G. Löwik en Mw. D. Berends-van der Meer
+31715264058 researchgynaecologie@lumc.nl

Immunotherapie van HPV-gerelateerde tumoren van cervix en vulva

In nauwe samenwerking met de afdelingen Klinische Oncologie, Pathologie en Klinische Farmacie en Toxicologie wordt onderzoek gedaan naar immunotherapeutische aspecten van de behandeling van HPV-gerelateerde tumoren van de cervix en vulva.

In vrijwel alle gevallen van baarmoederhalskanker en CIN, maar ook bijvoorbeeld in voorstadia van kanker van de schaamlippen (vulvaire intraepitheliale neoplasie, (VIN)), vagina of anus, wordt het humane papillomavirus (HPV) aangetroffen.  HPV type 16 is het belangrijkste type. In ongeveer 70% van de gezonde mensen zijn bepaalde afweercellen, de zgn. T-cellen, gericht tegen HPV-eiwitten detecteerbaar.  In patiënten met baarmoederhalskanker en andere HPV-geassocieerde aandoeningen zoals (voorstadia van) schaamlip-, vagina- en anuskanker is deze afweer tegen HPV gestoord. In het LUMC is een therapeutisch HPV16 vaccin ontwikkeld voor de behandeling van patiënten met HPV-gerelateerde ziekten van de cervix en vulva. Dit vaccin is in staat een sterke afweerreactie op te wekken in mensen die dat van nature niet kunnen. In een recent uitgevoerde studie is gebleken dat in ongeveer 80% van de vrouwen met HPV16+ VIN de afwijking kleiner werd of verdween na toedienen van dit vaccin.

Op dit moment vinden er verschillende studies plaats naar de werking van dit vaccin in patiënten met VIN en cervixcarcinoom.

Mw. M.J.G. Löwik en Mw. D. Berends-van der Meer
+31715264058
researchgynaecologie@lumc.nl

Behandelvaccin tegen reeds aanwezige baarmoederhalskanker komt steeds dichterbij.

Bron: COAG 

Kanker die door een virus is veroorzaakt, kan met een vaccin worden bestreden. Waar leidt dat toe?

Onderzoekers van het LUMC Leiden hebben een immunotherapie tegen schaamlipkanker ontwikkeld. Patiënten met een voorstadium van deze door een virus veroorzaakte kankersoort kregen een vaccin tegen het Humane Papillomavirus-16. Bij bijna de helft van de negentien behandelde patiënten verdwenen de tumorachtige afwijkingen en het virus volledig. Twee jaar later was dat nog steeds zo. Bij nog eenderde van de vrouwen was er wel duidelijk verbetering, maar ze genazen niet volledig. Vier vrouwen reageerden niet zichtbaar op de therapie.

De resultaten van het onderzoek zijn gepubliceerd in The New England Journal of Medicine. Ze zijn interessant omdat voor het eerst een therapeutisch vaccin goed blijkt te werken bij mensen met een door een virus veroorzaakte tumor. De Leidse onderzoekers hebben gekozen voor een nieuwe aanpak door zogeheten ‘lange synthetische peptiden’ te gebruiken. Peptiden zijn korte eiwitketens, in dit geval 25 tot 35 aminozuren lang. Het onderzoek biedt ook perspectief voor de behandeling van baarmoederhalskanker, omdat deze voor een belangrijk deel door hetzelfde virus, HPV-16, wordt veroorzaakt.

‘We hebben hiermee bewezen dat het principe van de genezende vaccinatie werkt. En dat we het immuunsysteem gericht kunnen activeren om voorstadia van tumoren op te ruimen’, zegt prof. Kees Melief, hoogleraar immunologie in Leiden, wiens groep de therapie heeft ontwikkeld. Melief is er vooral tevreden over dat specifieke cellen van het immuunsysteem zich door het vaccin heel gericht tegen het afwijkende weefsel keren, dat deze reactie beklijft en er geen tolerantie tegen het vaccin optreedt. De resultaten bewijzen ook dat de immuunreactie wezenlijk is voor de therapie. Vrouwen van wie het immuunsysteem slechts weinig door het vaccin geactiveerd wordt, hebben minder kans op genezing. Lees verder>>>>>>>>

Immunotherapy for cervical cancer: Research status and clinical potential

2010 Apr 1;24(2):109-29. doi: 10.2165/11532810-000000000-00000.

Immunotherapy for cervical cancer: Research status and clinical potential.

Source

National Taiwan University, Taipei, Taiwan.

Abstract

The high-risk types of human papillomavirus (HPV) have been found to be associated with most cervical cancers and play an essential role in the pathogenesis of the disease. Despite recent advances in preventive HPV vaccine development, such preventive vaccines are unlikely to reduce the prevalence of HPV infections within the next few years, due to their cost and limited availability in developing countries. Furthermore, preventive HPV vaccines may not be capable of treating established HPV infections and HPV-associated lesions, which account for high morbidity and mortality worldwide. Thus, it is important to develop therapeutic HPV vaccines for the control of existing HPV infection and associated malignancies. Therapeutic vaccines are quite different from preventive vaccines in that they require the generation of cell-mediated immunity, particularly T cell-mediated immunity, instead of the generation of neutralizing antibodies. The HPV-encoded early proteins, the E6 and E7 oncoproteins, form ideal targets for therapeutic HPV vaccines, since they are consistently expressed in HPV-associated cervical cancer and its precursor lesions and thus play crucial roles in the generation and maintenance of HPV-associated disease. Our review covers the various therapeutic HPV vaccines for cervical cancer, including live vector-based, peptide or protein-based, nucleic acid-based, and cell-based vaccines targeting the HPV E6 and/or E7 antigens. Furthermore, we review the studies using therapeutic HPV vaccines in combination with other therapeutic modalities and review the latest clinical trials on therapeutic HPV vaccines.

PMID:
20199126
[PubMed - indexed for MEDLINE]
PMCID:
PMC2913436
 

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