17 januari 2017: Lees ook deze review studie van de Cochrane: Library Exercise for women receiving adjuvant therapy for breast cancer. 

AUTHORS' CONCLUSIONS:

Exercise during adjuvant treatment for breast cancer can be regarded as a supportive self care intervention that probably results in less fatigue, improved physical fitness, and little or no difference in cancer-specific quality of life and depression. Exercise may also slightly improve cancer site-specific quality of life and cognitive function, while it may result in little or no difference in health-related quality of life.

26 april 2005: Bron: Psychooncology. 2004 Oct 14

Elke dag een fikse wandeling, maar niet extreem, terwijl een behandeling met chemo of bestraling wordt ondergaan voor borstkanker geeft klinisch aantoonbaar een significant positief effect (p=0.03) op de vermoeidheidsverschijnselen veroorzaakt door de behandeling. Aldus een grote gerandomiseerde fase III studie. Klinisch aantoonbaar betekent in dit geval niet alleen het gevoel maar werden bepaalde waarden zowel voor de test als na de test gemeten en bleken de verschillen aantoonbaar significant beter te zijn in de groep die elke dag een behoorlijke wandeling maakte. De conclusie van de onderzoekers is dan ook dat een gemiddeld bewegingsprogramma tijdens een behandeling van kanker de vermoeidheidsverschijnselen kunnen beperken. Op het verloop van de ziekte, het therapeutische effect werd geen significant effect gevonden. Eerst de grote fase III studie en daaronder het abstract van de fase II studie die dezelfde positieve effecten aantoonde en aan de basis lag van de fase III studie.

Exercise manages fatigue during breast cancer treatment: A randomized controlled trial.

Mock V, Frangakis C, Davidson NE, Ropka ME, Pickett M, Poniatowski B, Stewart KJ, Cameron L, Zawacki K, Podewils LJ, Cohen G, McCorkle R.
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, USA.

Fatigue is the most prevalent and debilitating symptom experienced by breast cancer patients receiving adjuvant chemotherapy or radiation therapy and few evidence-based treatments are available to manage this distressing side-effect. The purpose of this multi-institutional randomized controlled trial was to determine the effects of exercise on fatigue levels during treatment for breast cancer. Sedentary women (N=119) with Stage 0-III breast cancer receiving outpatient adjuvant chemotherapy or radiation therapy were randomized to a home-based moderate-intensity walking exercise program or to usual care for the duration of their cancer treatment. Of participants randomized to exercise, 72% adhered to the exercise prescription; 61% of the usual care group adhered. The intention-to-treat analysis revealed no group differences in part because of a dilution of treatment effect as 39% of the usual care group exercised and 28% of the exercise group did not. When exercise participation was considered using the data analysis method of instrumental variables with principal stratification, a clinically important and statistically significant (p=0.03) effect of exercise on pretest-to-posttest change in fatigue levels was demonstrated. Adherence to a home-based moderate-intensity walking exercise program may effectively mitigate the high levels of fatigue prevalent during cancer treatment. Copyright (c) 2004 John Wiley & Sons, Ltd.

PMID: 15484202 [PubMed - as supplied by publisher]

Cancer Pract. 2001 May-Jun;9(3):119-27.

Comment in:
Cancer Pract. 2001 May-Jun;9(3):113.

Fatigue and quality of life outcomes of exercise during cancer treatment.

Mock V, Pickett M, Ropka ME, Muscari Lin E, Stewart KJ, Rhodes VA, McDaniel R, Grimm PM, Krumm S, McCorkle R.
The Johns Hopkins University School of Nursing, Baltimore, Maryland 21211-4250, USA.

PURPOSE: Despite the recognition of fatigue as a common and distressing symptom during cancer treatment, there are few evidence-based interventions available to manage such fatigue. The purpose of this multi-institutional pilot study was to explore the effects of a home-based moderate walking exercise intervention on fatigue, physical functioning, emotional distress, and quality of life (QOL) during breast cancer treatment.

DESCRIPTION OF STUDY: Fifty-two women were recruited from five university hospital outpatient departments for this pilot study with an experimental design. Subjects were randomly assigned to the walking program or to usual care during adjuvant chemotherapy or radiation therapy for breast cancer. Symptoms, physical functioning, and QOL were measured at baseline, midtreatment, and at the end of treatment.

RESULTS: Women who exercised at least 90 minutes per week on 3 or more days reported significantly less fatigue and emotional distress as well as higher functional ability and QOL than women who were less active during treatment.

CLINICAL IMPLICATIONS: A home-based walking exercise program is a potentially effective, low-cost, and safe intervention to manage fatigue and to improve QOL during adjuvant chemotherapy or radiation therapy for breast cancer. This health-promoting self-care activity needs further testing in large randomized clinical trials.

Randomized Controlled Trial
PMID: 11879296 [PubMed - indexed for MEDLINE]


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