28 december 2023: lees ook dit artikel: https://kanker-actueel.nl/lichaamsbeweging-verhoogt-het-energieniveau-en-de-kwaliteit-van-leven-van-patienten-met-uitgezaaide-borstkanker-blijkt-uit-de-preferable-effect-studie.html

23 augustus 2019: Bron: The Oncologist August 2019theoncologist.2019-0262

Dat bewegen en sporten goed is voor kankerpatienten en ook voor vrouwen met borstkanker is al lang bekend. Zie o.a. de literatuurlijst niet-toxische middelen en behandelingen specifiek bij borstkanker van arts-bioloog drs. Engelbert Valstar en zie ook enkele publicaties specifiek bij borstkankerpatienten in gerelateerde artikelen.

Een nieuwe Zweedse postpectieve studie (OptiTrain studie) bij totaal 240 vrouwen liet zien dat onder begeleiding 16 weken van samen een weerstandstraining en intensieve interval trainingen tijdens de chemokuren er veel minder vrouwen tijdens de chemokuren opgenomen moesten worden in het ziekenhuis. 3 procent uit de studiegroep en 15 procent uit de groep van vrouwen die standaard zorg kregen. Ook kwam er veel minder trombocytopenie (sterke verlaging van witte bloedplaatjes) voor bij de vrouwen die onder begeleiding actief bewogen. 

Er zat geen statistisch verschil in vermindering van de dosering van de chemo tijdens de kuren. 

Het studierapport: Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial is tegen betaling in te zien.

Andere studiepublicaties die de Oncologist aanbeveelt en gerelateerd zijn aan dit onderwerp zijn ook:

We recommend

  1. Effectiveness of Oncologist‐Referred Exercise and Healthy Eating Programming as a Part of Supportive Adjuvant Care for Early Breast Cancer
    Amy A. Kirkham et al., Oncologist,2017
  2. A Longitudinal Study of the Association of Clinical Indices of Cardiovascular Autonomic Function with Breast Cancer Treatment and Exercise Training
    Amy A. Kirkham et al., Oncologist,2018
  3. Impact of Guideline‐Discordant Treatment on Cost and Health Care Utilization in Older Adults with Early‐Stage Breast Cancer
    Courtney P. Williams et al.,Oncologist, 2018
  4. Prevention in the Balance
    Victor G. Vogel, Oncologist, 2002
  5. High-Dose Chemotherapy and Peripheral Blood Progenitor Cell Transplantation in the Treatment of Breast Cancer
    William P. Peters et al., Oncologist,2000
  1. Effects of Exercise on Chemotherapy Completion and Hospitalization Rates
    PracticeUpdate, 2019
  2. Effects of high-intensity interval training on vascular function in breast cancer survivors undergoing anthracycline chemotherapy: design of a pilot study
    Kyuwan Lee et al., BMJ Open, 2018
  3. Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise
    Jonathan M. Peake et al., American Journal of Physiology - Endocrinology and Metabolism, 2014
  4. Effect of Physical Activity During Adjuvant Chemotherapy
    PracticeUpdate, 2015
  5. Color, NorthShore Pilot Project Results Reported at ACMG
    Precision Oncology News, 2019

Hier het abstract van de nieuwe Zweedse studie:

The Oncologist August 2019theoncologist.2019-0262

First Published Online August 7, 2019

doi:10.1634/theoncologist.2019-0262

Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial

  1. Helene Rundqvistb

+Author Affiliations

  1. a Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
  2. b Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
  3. c Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
  4. d Cancer Theme, Karolinska University Hospital, Stockholm, Sweden
  1. ↵*Corresponding author: Sara Mijwel, Ph.D., Department of Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Alfred Nobel alle 23, 141 83 Huddinge, Sweden. Telephone: 46‐761625352; e‐mail: sara.mijwel@ki.se
  • Received April 5, 2019.
  • Revision received June 18, 2019.
  • Accepted July 2, 2019.
  • Published online before print August 7, 2019.

  • Disclosures of potential conflicts of interest may be found at the end of this article.

Abstract

Background.

Exercise during chemotherapy is suggested to provide clinical benefits, including improved chemotherapy completion. Despite this, few randomized controlled exercise trials have reported on such clinical endpoints. From the OptiTrain trial we previously showed positive effects on physiological and health‐related outcomes after 16 weeks of supervised exercise in patients with breast cancer undergoing chemotherapy. Here, we examined the effects of exercise on rates of chemotherapy completion and hospitalization, as well as on blood cell concentrations during chemotherapy.

Patients and Methods.

Two hundred forty women scheduled for chemotherapy were randomized to 16 weeks of resistance and high‐intensity interval training (RT‐HIIT), moderate‐intensity aerobic and high‐intensity interval training (AT‐HIIT), or usual care (UC). Outcomes included chemotherapy completion, hospitalization, hemoglobin, lymphocyte, thrombocyte, and neutrophil concentrations during chemotherapy.

Results.

No significant between‐groups differences were found in the proportion of participants who required dose reductions (RT‐HIIT vs. UC: odds ratio , 1.08; AT‐HIIT vs. UC: OR, 1.39), or average relative dose intensity of chemotherapy between groups (RT‐HIIT vs. UC: effect size , 0.08; AT‐HIIT vs. UC: ES, −0.07). A significantly lower proportion of participants in the RT‐HIIT group (3%) were hospitalized during chemotherapy compared with UC (15%; OR, 0.20). A significantly lower incidence of thrombocytopenia was found for both RT‐HIIT (11%) and AT‐HIIT (10%) versus UC (30%; OR, 0.27; OR, 0.27).

Conclusion.

No beneficial effects of either RT‐HIIT or AT‐HIIT on chemotherapy completion rates were found. However, combined resistance training and high‐intensity interval training were effective to reduce hospitalization rates, and both exercise groups had a positive effect on thrombocytopenia. These are important findings with potential positive implications for the health of women with breast cancer and costs associated with treatment‐related complications.

Implications for Practice.

Completing the prescribed chemotherapy regimen is strongly associated with a good prognosis for patients with primary breast cancer. Despite this, treatment‐induced side effects make it necessary to reduce or alter the treatment regimen and can also lead to hospitalization. Exercise during chemotherapy is suggested to provide clinical benefits, including improved chemotherapy completion. This study showed that combined resistance and high‐intensity interval training during chemotherapy resulted in lower hospitalization rates and a lower incidence of thrombocytopenia in women with breast cancer undergoing chemotherapy. However, no beneficial effects of either exercise program on chemotherapy completion rates were found, which is in contrast to previous findings in this population. The findings reported in the current article have positive implications for the health of women with breast cancer and costs associated with treatment‐related complications.

borstkanker, beweging, weerstandstraining, trombocytopenie, chemokuren, verlaging dosering, ziekenhuisopname


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