Mocht u kanker-actueel de moeite waard vinden en ons willen ondersteunen om kanker-actueel online te houden dan kunt u ook via uw lidmaatschapsnummer korting krijgen bij enkele bedrijven. 

En raadpleeg ook literatuurlijst niet-toxische middelen en behandelingen specifiek bij borstkanker van arts-bioloog drs. Engelbert Valstar

En zie ook onder preventie bij borstkanker bij fysieke activiteiten

19 september 2018: Bron: Breast Cancer Research and Treatment

Fysieke activiteit heeft grote invloed op de overall overleving van borstkankerpatienten blijkt uit verschillende grote studies. (zie in gerelateerde artikelen). In deze kleine studie (Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1 ) komt naar voren dat met name het gen L3MBTL1 een grote rol daarin speelt. Het gen L3MBTL1 staat bekend als een onderdrukker van het zogeheten DNA-methylatie proces, dus het ontstaan van mutaties. 

Gebaseerd op een lijst van veel voorkomende DNA mutaties, analyseerden de onderzoekers de genexpressie gerelateerd aan de algehele overleving bij borsttumoren. Uit die genen werden drie genen gevonden waarvan de methylatie na de training was verminderd en gunstig  bleek in verband met totale overleving, dwz hogere expressie geassocieerd met betere overleving.

Van de drie genen lijkt L3MBTL1 een vermoedelijk tumoronderdrukkend gen. Een gen dat in hoofdzaak wordt geactiveerd in kiemlijnstamcellen. De analyses van tumorkenmerken bij patiënten toonden aan dat een hoge expressie van L3MBTL1 werd geassocieerd met laaggradige en hormoonreceptorpositieve tumoren, evenals een laag risico op een recidief / terugkeer van de ziekte en het overlijden aan borstkanker.
De onderzoekers concluderen dan ook dat toenemende fysieke activiteit na een diagnose van borstkanker de epigenetische regulatie van tumoronderdrukkende genen kan beïnvloeden, die gunstige effecten hebben op de overlevingskansen van borstkankerpatiënten.

Afbeeldingsresultaat voor images of fysical activityBron afbeelding: https://www.123rf.com/stock-photo/physical_activity.html?sti=mprzucxxfwqmxoe765|

Voor het volledige studierapport: Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1 moet betaald worden dus kan niet zo heel veel meer uit deze studie halen, maar onder het abstract staat wel een referentielijst.

En zie dus ook in gerelateerde artikelen voor meta analyses. 

Hier het abstract van deze studie:

Breast Cancer Research and Treatment

, Volume 133, Issue 1, pp 127–135 | Cite as

Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1

  • Hongmei Zeng
  • Melinda L. Irwin
  • Lingeng Lu
  • Harvey Risch
  • Susan Mayne
  • Lina Mu
  • Qian Deng
  • Luca Scarampi
  • Marco Mitidieri
  • Dionyssios Katsaros
  • Herbert Yu
  • Hongmei Zeng
    • 1
    • 2
  • Melinda L. Irwin
    • 1
  • Lingeng Lu
    • 1
  • Harvey Risch
    • 1
  • Susan Mayne
    • 1
  • Lina Mu
    • 3
  • Qian Deng
    • 1
  • Luca Scarampi
    • 4
  • Marco Mitidieri
    • 4
  • Dionyssios Katsaros
    • 4
  • Herbert Yu
    • 1
  1. 1.Department of Epidemiology and Public HealthYale Cancer Center, Yale University School of Public HealthNew HavenUSA
  2. 2.Department of Cancer Epidemiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)Peking University School of Oncology, Beijing Cancer Hospital and InstituteBeijingChina
  3. 3.Department of Social and Preventive Medicine, School of Public Health and Health ProfessionsUniversity at Buffalo, The State University of New YorkBuffaloUSA
  4. 4.Department of Obstetrics and Gynecology, Gynecologic Oncology and Breast Cancer UnitUniversity of TurinTurinItaly
Preclinical study
First Online: 12 August 2011

Abstract

The study was conducted to determine the effect of physical activity on DNA methylation and to predict the consequence of this effect concerning gene expression and breast cancer survival. Blood samples, collected from 12 breast cancer patients who participated in a randomized clinical trial of exercise, were examined for exercise-related changes in DNA methylation using a methylation microarray. Tumor samples of 348 breast cancer patients were analyzed with qRT-PCR and qMSP to determine gene expression and methylation identified in the microarray analysis. Cox regression models were developed to predict survival outcomes in association with gene expression and methylation. After 6 months of moderate-intensity aerobic exercise, changes in DNA methylation (P < 5 × 10−5) in peripheral blood leukocytes were detected in 43 genes from a panel of 14 495. Based on the list, we analyzed gene expression in association with overall survival in breast tumors and found three genes whose methylation was reduced after exercise were favorably in association with overall survival, i.e., higher expression associated with better survival. Of the three genes, L3MBTL1 was a putative tumor suppressor gene with known function to repress chromatin for transcription, which is activated mainly in germline stem cells. Further analyses of tumor features among patients indicated that high expression of L3MBTL1 was associated with low grade and hormone receptor–positive tumors, as well as low risk of disease recurrence and breast cancer death. In conclusion, the study suggests that increasing physical activity after a breast cancer diagnosis may affect epigenetic regulation of tumor suppressor genes, which have favorable impacts on survival outcomes of breast cancer patients.

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Copyright information

© Springer Science+Business Media, LLC. 2011

borstkanker, tumoronderdrukkend gen L3MBTL1, DNA mutaties, overall overleving, fysieke activiteit, efectiviteit van wandelen en sporten


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