12 december 2012: lees ook dit artikel: 

https://kanker-actueel.nl/gezond-dieet-met-vloeibaar-eten-gedurende-3-tot-5-maanden-en-stapsgewijs-onder-begeleiding-terug-naar-vast-voedsel-en-gezonde-leefstijl-geneest-met-48-tot-73-procent-van-de-patienten-met-diabetes-2.html

24 juni 2012: Bron: ACTA Dermata Venereologica doi: 10.2340/00015555-1358

Melk en melkproducten en voeding met een hoge glycemische index - de snelheid waarmee koolhydraten worden afgebroken en als glucose in het bloed wordt opgenomen, spelen grote rol in de vorming van acne en staan aan de basis van veel immuunziektes als suikerziekte - diabetes 2, maar ook op langere termijn aan de basis van sommige vormen van kanker. (zie verder wat glycemische index betekent bij Wikipedia)
Dit blijkt uit 2 gerandomiseerde studies en onderstreept de rol van een westers voedingspatroon in de pathogenese van acne. Uit deze twee studies blijkt dat acne nagenoeg  afwezig is in de bevolking die eten en drinken volgens een voedingspatroon met voedingstoffen met een lage glycemische lading en weinig of geen koemelk of zuivelproducten gebruiken. Daarmee wordt volgens de onderzoekers bewezen dat een voedingspatroon met een lage glycemische lading gunstige therapeutische effecten kan hebben bij het voorkomen en behandelen  
van acne. Acne moet worden beschouwd als een door de zogeheten mTORC1 gedreven welvaartsziekten, zoals obesitas, diabetes type 2 en kanker en worden veelal veroorzaakt door een westers dieet. Vroege dieetadvisering van tieners met of zonder acne kan helpen bij het verbeteren van acne, maar kan ook op lange termijn schadelijke effecten van een westers voedingspatroon  op meer ernstige door mTORC1 gedreven welvaartsziekten voorkomen, aldus de onderzoekers. Op de website www.glycemische-index.com kunt u staatjes inzien van welke voeding een hoge en welke voeding een lage glycemische lading heeft.

Hier de abstracten van de 2 gerandomiseerde studies. Van 1 studie - Diet in Acne: Further Evidence for the Role of Nutrient Signalling in Acne Pathogenesis - is op de website van Medical Journals het volledige studierapport  gratis in te zien.

Further Evidence for the Role of Nutrient Signalling in Acne Pathogenesis

Bodo C. Melnik

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany

Recent evidence underlines the role of Western diet in the pathogenesis of acne. Acne is absent in populations consuming Palaeolithic diets with low glycaemic load and no consumption of milk or dairy products. Two randomized controlled studies, one of which is presented in this issue of Acta Dermato-Venereologica, have provided evidence for the beneficial therapeutic effects of low glycaemic load diets in acne. Epidemiological evidence confirms that milk consumption has an acne-promoting or acne-aggravating effect. Recent progress in understanding the nutrient-sensitive kinase mammalian target of rapamycin complex 1 (mTORC1) allows a new view of nutrient signalling in acne by both high glycaemic load and increased insulin-, IGF-1-, and leucine signalling due to milk protein consumption. Acne should be regarded as an mTORC1-driven disease of civilization, like obesity, type 2 diabetes and cancer induced by Western diet. Early dietary counselling of teenage acne patients is thus a great opportunity for dermatology, which will not only help to improve acne but may reduce the long-term adverse effects of Western diet on more serious mTORC1-driven diseases of civilization. Key words: acne; diet; glycaemic load; milk; mTORC1.

(Accepted February 29, 2012.)

Acta Derm Venereol 2012; 92: XX–XX.

Bodo C. Melnik, Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Sedanstrasse 115, DE-49090 Osnabrück, Germany. E-mail: melnik@t-online.de 

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Restriction of milk consumption or generation of less insulinotropic milk will have an enormous impact on the prevention of epidemic western diseases like obesity, diabetes mellitus, cancer, neurodegenerative diseases and acne

Nestle Nutr Workshop Ser Pediatr Program. 2011;67:131-45. Epub 2011 Feb 16.

Evidence for acne-promoting effects of milk and other insulinotropic dairy products.

Source

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.

Abstract

Acne vulgaris, the most common skin disease of western civilization, has evolved to an epidemic affecting more than 85% of adolescents. Acne can be regarded as an indicator disease of exaggerated insulinotropic western nutrition. Especially milk and whey protein-based products contribute to elevations of postprandial insulin and basal insulin-like growth factor-I (IGF-I) plasma levels. It is the evolutional principle of mammalian milk to promote growth and support anabolic conditions for the neonate during the nursing period. Whey proteins are most potent inducers of glucose-dependent insulinotropic polypeptide secreted by enteroendocrine K cells which in concert with hydrolyzed whey protein-derived essential amino acids stimulate insulin secretion of pancreatic β-cells. Increased insulin/IGF-I signaling activates the phosphoinositide-3 kinase/Akt pathway, thereby reducing the nuclear content of the transcription factor FoxO1, the key nutrigenomic regulator of acne target genes. Nuclear FoxO1 deficiency has been linked to all major factors of acne pathogenesis, i.e. androgen receptor transactivation, comedogenesis, increased sebaceous lipogenesis, and follicular inflammation. The elimination of the whey protein-based insulinotropic mechanisms of milk will be the most important future challenge for nutrition research. Both, restriction of milk consumption or generation of less insulinotropic milk will have an enormous impact on the prevention of epidemic western diseases like obesity, diabetes mellitus, cancer, neurodegenerative diseases and acne.

Copyright © 2011 S. Karger AG, Basel.

PMID:
 
21335995
 
[PubMed - indexed for MEDLINE]

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