Als u de informatie op kanker-actueel waardeert wilt u misschien donateur worden van onze Stichting Gezondheid Actueel. Wij zijn ook een ANBI organisatie. Als donateur kunt u korting krijgen op voedingssupplementen bij verschillende bedrijven.

 Bij Oriveda krijgen onze donateurs 25% korting op extracten van medicinale paddenstoelen. Nog een reden om donateur te worden als u extracten van medicinale paddenstoelen wilt gaan gebruiken misschien?

30 december 2018: lees ook dit artikel: 

https://kanker-actueel.nl/extracten-van-medicinale-paddenstoelen-worden-ook-in-reguliere-oncologie-meer-en-meer-gezien-als-een-natuurlijke-behandeling-van-verschillende-vormen-van-kanker-blijkt-uit-recente-reviewstudie.html

17 december 2018: lees ook dit artikel: 

https://kanker-actueel.nl/waar-moet-je-op-letten-bij-de-aankoop-van-extracten-van-medicinale-paddenstoelen-hier-wat-richtlijnen.html

1 maart 2018: zie ook dit artikel:  

https://kanker-actueel.nl/champignons-bewerkt-met-speciale-belichting-hebben-daarmee-veel-extra-vitamine-d-en-kunnen-vitamine-d-supplementen-vervangen.html

17 mei 2012: recent is verschenen het abstract van een review studie uit 2012 over de waarde van PSK - polysaccharide K (KRESTIN(®) bij vele vormen van kanker - Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN®): review of development and future perspectives - waaronder vooral ook bij vormen van spijsverteringskanker, zoals darmkanker, rectumkanker, maagkanker enz.. Zie ook in gerelateerde artikelen voor meer artikelen en informatie. Als u hier klikt kunt u het volledige studie rapport van deze review studie gratis inzien.

Hier het abstract van deze studie, onderaan meer algemene informatie. In linkerkolom staan artikelen met meer toegespitste informatie.

 Surg Today. 2012 January; 42(1): 8–28.
Published online 2011 December 6. doi:  10.1007/s00595-011-0075-7
PMCID: PMC3253283

Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN®): review of development and future perspectives

Abstract

The mechanism of action of protein-bound polysaccharide K (PSK; KRESTIN®) involves the following actions: (1) recovery from immunosuppression induced by humoral factors such as transforming growth factor (TGF)-β or as a result of surgery and chemotherapy; (2) activation of antitumor immune responses including maturation of dendritic cells, correction of Th1/Th2 imbalance, and promotion of interleukin-15 production by monocytes; and (3) enhancement of the antitumor effect of chemotherapy by induction of apoptosis and inhibition of metastasis through direct actions on tumor cells. The clinical effectiveness of PSK has been demonstrated for various cancers. In patients with gastric or colorectal cancer, combined use of PSK with postoperative adjuvant chemotherapy prolongs survival, and this effect has been confirmed in multiple meta-analyses. For small-cell lung carcinoma, PSK in conjunction with chemotherapy prolongs the remission period. In addition, PSK has been shown to be effective against various other cancers, reduce the adverse effects of chemotherapy, and improve quality of life. Future studies should examine the effects of PSK under different host immune conditions and tumor properties, elucidate the mechanism of action exhibited in each situation, and identify biomarkers.

De van mushrooms (paddestoelen) afgeleide middelen PSP en PSK worden algemeen beschouwd als zeer sterke antioxidanten en immuunversterkend. Zie bv. de literatuurlijst van dokter Valstar waarin een groot aantal wetenschappelijke fase III studies worden genoemd die de werking van PSK met name bevestigen. Ook de Maitake schijnt therapeutische waarde te hebben en in Japan is een grote tienjarige fase III studie gedaan met AHCC, een mix van medicinale paddestoelen bij levertumoren met groot significant positief effect . Van een Chinese arts kregen wij uitstekende informatie over PSK en PSP opgestuurd. Beschrijvingen ook bij welke soorten kanker dit middel goed werkte en alles met officiële literatuur gestaafd. Zie ook studieresultaten PSK en maagkanker op pagina onderzoek en voeding.

Een paar citaten van de site in het Engels:

Mushroom Immunoceuticals ­ An Overview

Immunoceuticals isolated from more than 30 mushroom species have shown anticancer action in animals.2 Only a handful have been taken to the next step: objective clinical assessment for anticancer potential in humans. Of these relative few, all are chemically ß-D-glucan in nature (i.e., linear polymers of d-glucose with other monosaccharides) or ß-D-glucans linked to proteins (so-called polysaccharide-peptides, more formally termed "proteoglycans"). As a rule, the protein-linked glucans have greater immuno-potentiation activity than the corresponding free glucans.3

The basic ß-D-glucan is a repeating structure, with its D-glucose molecules joined together in linear chains by beta-bonds (ß). These can extend from the carbon 1 of one saccharide ring to the carbon 3 of the next (ß1-3), from carbon 1 to carbon 4 (ß1-4), or from carbon 1 to carbon 6 (ß1-6). Most often there is a main chain which is either ß1-3, ß1-4, or mixed ß1-3, ß1-4 with ß1-6 side chains. The basic repeating structure of a ß1-3 glucan with ß1-6 side chains is shown in figure 1 and figure 2 (Noot redactie: wie afbeeldingen en schema's wil inzien dat kan mail ons voor informatie) Hetero-ß-D-glucans, i.e., linear polymers of glucose with other D-monosaccharides, can have anticancer activity, but alpha-D-glucans from mushrooms usually lack anticancer activity.6

Six mushroom preparations have shown clinically significant efficacy against human cancers: lentinan, schizophyllan, Active Hexose Correlated Compound (AHCC), Maitake D-Fraction, Polysaccharide-K, and Polysaccharide-P. Since lentinan and schizophyllan have limited oral bioavailability, and therefore fail to meet the definition of immunoceutical, they will only be given a cursory review. AHCC and Maitake D-Fraction are still in the early stages of investigation. The remaining two have been subjected to in-depth application against cancers in humans.

PSK Constituents

PSK is prepared from strain CM-101 of Coriolus versicolor by water extraction and salting out. It is approximately 62-percent polysaccharide and 38-percent protein, although the content of both can vary. The glucan portion of PSK consists of a ß1-4 main chain and ß1-3 side chains, with ß1-6 side chains that bond to a polypeptide moiety through O- or N-glycosidic bonds. The polypeptide portion is relatively rich in aspartic, glutamic, and other acidic amino acids. PSK is a set of molecules whose molecular weight ranges from 94,000 to 100,000 daltons, and is bioavailable by the oral route.23 Studies with C14-labeled PSK in mice confirmed its full molecular spectrum is absorbed within 24 hours following administration. Conventional toxicological assessments indicate PSK is non-toxic: its oral LD50 is low and no abnormalities have been observed in subacute and chronic toxicity tests.

Studieverslagen PSK en darmkanker:

PSK and Colorectal Cancer

As its benefits to stomach cancer became established (Noot redactie: zie studieverslagen pagina onderzoek en voeding-PSK en maagkanker), PSK was assessed for its potential anticancer activity in patients with advanced colorectal cancer. In an eight-year, double-blind trial,36 111 patients with colorectal cancer (pathologic stages III and IV, Dukes Stage C) were randomized into two groups, then administered PSK or placebo in decreasing doses over time, as per Kondo and Torisu's earlier gastric cancer study. PSK, 3 grams/day, was given until two months after surgery, followed by 2 grams/day until 24 months, and 1 gram/day thereafter. PSK significantly improved both the eight-year survival rate (to 40% vs. 25%, p<0.05) and the disease-free interval (to 25% vs 8%, p<0.05).

In 1992, Mitomi et al, in the Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum, published the results of a large multicenter trial with PSK in colorectal cancer.37 They recruited 448 patients from 35 institutions in Japan, randomized them into two groups, then put them through surgery and chemotherapy plus or minus PSK. After the third year, PSK had significantly improved survival and the disease-free period in the colon group (p<0.05 in both)(see Figure 4c), but not in the rectal cancer group (p=0.12).

  Voor wie de volledige informatie wilt lezen kunnen we die ook digitaal opsturen.


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