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Helicobacter. 2005 Apr;10(2):139-45.
Een dubbelblinde gerandomiseerde studie bij 189 patiënten met een reeds aangetoonde infectie met de Heliobactor pylori bewijst dat een dagelijks glas cranberrysap de uitbreiding van de Heliobactor bacterie significant remt en zelfs mensen ervan af helpt. 11 patiënten waren na resp. 35 en 90 dagen vrij van de bacterie tegenover slechts 2 uit de placebogroep. Dit is een significant resultaat (p < .05> Maagkanker wordt heel vaak veroorzaakt door deze bacterie en cranberrysap werkt dus preventief en wellicht zelfs therapeutisch tegen ontstaan of behandelen van maagkanker.
Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial. Zhang L, Ma J, Pan K, Go VL, Chen J, You WC. School of Oncology, Peking University, Beijing Institute for Cancer Research, China. BACKGROUND: Helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer. This study postulated that cranberry juice would be effective in the suppression of H. pylori in an endemically infected population at high risk for gastric cancer.
MATERIALS AND METHODS: A prospective, randomized, double-blind, placebo-controlled trial was conducted in Linqu County of Shandong Province, China, where 189 adults aged 48.9 +/- 11.2 years (mean +/- SD) with H. pylori infection were randomly divided into two groups: cranberry juice (n = 97) and placebo (n = 92). Participants were assigned to orally receive two 250-ml juice boxes of cranberry juice or matching placebo beverage daily for 90 days. The degree of H. pylori infection was determined using the 13C-urea breath test before randomization at 35 and 90 days of intervention to assess the efficacy of cranberry juice in alleviating infection.
RESULTS: A total of 189 subjects with positive 13C-urea breath test results prior to randomization completed the study. At day 35 of intervention, 14 of the 97 (14.43%) from the the cranberry juice treatment group and 5 of the 92 (5.44%) of the placebo recipients had negative 13C-urea breath test results. After 90 days, the study concluded that 14 of the 97 subjects in the cranberry juice treatment group versus 5 of the 92 in the placebo group yielded negative test results. Eleven individuals from the cranberry juice treatment group and only two from the placebo group were negative at 35 and 90 days of experiment. These results are significant (p < .05).
CONCLUSIONS: Regular consumption of cranberry juice can suppress H. pylori infection in endemically afflicted populations.
PMID: 15810945 [PubMed - in process]
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