Zie ook in gerelateerde artikelen

Raadpleeg ook literatuurlijst niet-toxische middelen en behandelingen specifiek bij borstkanker van arts-bioloog drs. Engelbert Valstar

25 maart 2024: als aanvulling op onderstaande studieresultaten hier de resultaten uit een kleinschalige studie waarin 21 borstkankerpatiënten met gevorderde borstkanker 8 weken lang onder begeleiding een plantaardig dieet volgden en cardiometabolische, hormonale en tumormarkers werden beoordeeld bij aanvang, op 4 weken en op 8 weken en werden vergeleken met 11 vrouwen die alleen beste zorg kregen.

Resultaten:

Binnen de interventiegroep daalde het gemiddelde gewicht na 8 weken met 6,6% (p < 0,01). De nuchtere insuline daalde van 16,8 uIU/l naar 11,2 uIU/l (p < 0,01), gelijktijdig met een significant verminderde insulineresistentie. Het totale cholesterol daalde van 193,6 mg/dl naar 159 mg/dl (p < 0,01), en lipoproteïne-cholesterol met lage dichtheid (LDL) daalde van 104,6 mg/dl naar 82,2 mg/dl (p < 0,01). Het totale testosteron bleef onveranderd, maar het vrije testosteron vertoonde een lagere trend binnen de interventiegroep (p = 0,08), aangezien het geslachtshormoonbindende globuline toenam van 74,3 nmol/l naar 98,2 nmol/l (p < 0,01). Er waren geen significante verschillen in kankerprogressiemarkers in week 8, hoewel de gemiddelde CA 15-3, CA 27,29 en CEA lager waren in de interventiegroep (respectievelijk p = 0,53, p = 0,23 en p = 0,54) vergeleken met de controlegroep. , indien aangepast voor de basislijn.

Volledige abstract staat onderaan dit artikel

6 december 2023: Bron: Journal of Clinical Oncology 41, no. 34 (December 01, 2023) 5285-5295.

De Leanerstudie, een gerandomiseerde studie bij 173 operabele borstkankerpatiënten met stadium I tot III, laat zien dat wanneer deze patiënten tijdens hun preoperatieve chemo onder begeleiding een half jaar een plantaardig dieet volgen plus extra beweging dagelijks dit van grote invloed is op het aantal complete remissies op moment van de operatie. 53% van de dieetgroep versus 28% van de beste zorggroep bereikten een complete remissie op moment dat de operatie plaatsvond.

De onderzoekers evalueerden bij 173 vrouwen ( 86 vs 87 patiënten) met stadium I tot III borstkanker die chemotherapie kregen. Zij zagen bij de operatie sterk verbeterde pathologische complete responspercentages in de interventiegroep vergeleken met die in de gebruikelijke beste zorggroep (53% versus 28%; P = .037).

De begeleiding in de interventiegroep werd individueel gegeven door geregistreerde diëtisten en omvatte vier wekelijkse sessies in de eerste maand, twee tweewekelijkse sessies gedurende de tweede en derde maand, en daarna 3 maandelijkse sessies.

Hier het belang van deze studie:

CONTEXT

Belangrijkste doelstelling

Verbetert lichaamsbeweging en het eten van een gezond dieet de voltooiing van de chemotherapie en de pathologische complete respons (pCR) bij vrouwen met de diagnose borstkanker en die chemotherapie krijgen?
Kennis gegenereerd
De interventie leidde tot verbeteringen in de kwaliteit van het dieet, de fysieke activiteitsniveaus en de pCR-percentages vergeleken met de gebruikelijke zorg (UC). De voltooiingspercentages van chemotherapie waren vergelijkbaar voor vrouwen die willekeurig waren toegewezen aan interventie versus UC.
Relevantie
Er zijn veel redenen om een gezond dieet en regelmatige lichaamsbeweging aan te moedigen bij vrouwen met borstkanker die chemotherapie nodig hebben. Deze studie toont aan dat het mogelijk is en mogelijk de pCR verhoogt. Niet-farmacologische interventies verdienen grote aandacht en passende onderzoeken.*
(Relevantiegedeelte geschreven door JCO Senior Deputy Editor, Kathy D. Miller, MD.)

Een grafiek die het verschil in complete remissies aanduidt tussen de twee groepen:

Het studierapport is gratis in te zien. Klik op de titel van het abstract:

ORIGINAL REPORTS

Cancer Prevention and Control

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Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study

Tara Sanft

, MD1,2; Maura Harrigan, RD, MS, CSO3; Courtney McGowan, RD, CSO3; Brenda Cartmel

, PhD2,3; Michelle Zupa

, BS3; Fang-Yong Li

, MS3; ...Show More

Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: http://creativecommons.org/licenses/by-nc-nd/4.0/

WFPB dietary - Whole Food Plant Based dietary changes during treatment for metastatic breast cancer are well tolerated and significantly improve weight, cardiometabolic and hormonal parameters. Longer studies are warranted to assess the durability of changes.

A whole-food, plant-based randomized controlled trial in metastatic breast cancer: weight, cardiometabolic, and hormonal outcomes

Clinical trial
Open access
Published: 06 March 2024

(2024)
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Abstract

Purpose

Breast cancer treatment is associated with weight gain, and obesity and its related cardiometabolic and hormonal risk factors have been associated with poorer outcomes. Dietary intervention may address these risk factors, but limited research has been done in the setting of metastatic breast cancer requiring systemic therapy.

Methods

Women with metastatic breast cancer on stable treatment were randomized 2:1 to an 8-week intervention (n = 21) or control (n = 11). The intervention included weekly assessment visits and an ad libitum whole-food, plant-based (WFPB) diet with provided meals. Cardiometabolic, hormonal, and cancer markers were assessed at baseline, 4 weeks, and 8 weeks.

Results

Within the intervention group, mean weight decreased by 6.6% (p < 0.01) after 8 weeks. Fasting insulin decreased from 16.8 uIU/L to 11.2 uIU/L (p < 0.01), concurrent with significantly reduced insulin resistance. Total cholesterol decreased from 193.6 mg/dL to 159 mg/dL (p < 0.01), and low-density lipoprotein (LDL) cholesterol decreased from 104.6 mg/dL to 82.2 mg/dL (p < 0.01). Total testosterone was unchanged, but free testosterone trended lower within the intervention group (p = 0.08) as sex hormone binding globulin increased from 74.3 nmol/L to 98.2 nmol/L (p < 0.01). There were no significant differences in cancer progression markers at week 8, although mean CA 15-3, CA 27.29, and CEA were lower in the intervention group (p = 0.53, p = 0.23, and p = 0.54, respectively) compared to control, when adjusted for baseline.

Conclusion

WFPB dietary changes during treatment for metastatic breast cancer are well tolerated and significantly improve weight, cardiometabolic and hormonal parameters. Longer studies are warranted to assess the durability of changes.

Trial registration First registered at Clinicaltrials.gov (NCT03045289) on February 7, 2017.

Conclusion

Our whole-food, plant-based intervention among women with metastatic breast cancer is feasible and results in clinically significant improvements in weight and related cardiometabolic and hormonal risk factors. This is one of the first RCTs to demonstrate that dietary changes during systemic treatment are well tolerated and result in these clinically important improvements. This is particularly relevant for this population, which is highly interested in nutrition and concerned with treatment-related weight gain, its comorbid conditions, and its implications for cancer-related outcomes. Trials of longer duration are required to understand the sustainability of these findings as well as their effects on cancer progression and mortality.

Data availability

The data underlying this article are available by request at https://gitlab-public.circ.rochester.edu/WFPB-breast-cancer/biomarkers.

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Groene thee extract (EFGG) stopt significant groei borstkankercellen blijkt uit gerandomiseerde dierstudies.

Intraveneus curcumine in combinatie met chemo (paclitaxel) bij borstkankerpatienten met uitgezaaide borstkanker geeft betere respons (plus 23 procent) en lichamelijk welbevinden in vergelijking met een placebo na 12 weken chemokuren copy 1

Japanse leefstijl en voeding geeft voor Japanese vrouwen met borstkanker 29% grotere overlevingskans (10 jaar) in vergelijking met vrouwen in de USA. Recent studie rapport toegevoegd.

Lijnzaad stimuleert significant borstkankercel sterfte en heeft therapeutisch positief effect op borsttumormarkers, blijkt uit kleinschalige (32 patiënten) , maar wel gerandomiseerde dubbelblinde placebo gecontroleerde studie

Melkzuurbacterien - probiotica aanwezig in gezond borstweefsel beschermt vrouwen tegen borstkanker blijkt uit kleinschalige studie copy 2

Olijfolie verdubbelt effect van Herceptin bij borstkanker en beschermt tegen recidief van borstkanker.

Sojabonen, tofu en isoflavonen geven een significant preventief effect op lager risico van krijgen van borstkanker bij vrouwen in de leeftijdsfase voor de overgang

Vlees: Meisjes die in hun adolescentietijd veel rood vlees eten hebben een significant vergroot risico op het krijgen van borstkanker voor de overgang

Vrouwen die te zwaar zijn (veel en slecht eten), dagelijks alcohol drinken en roken hebben sterk verhoogde kans op recidief van hormoongevoelige borstkanker in tweede borst.

Visolie: Vrouwen die borstkanker overleven hebben baat bij dagelijks een extra dosis Omega-3 vetten in de vorm van visolie capsules of extra vis eten om chronische vermoeidheid tegen te gaan

Wetenschappelijke artikelen met een medisch technische analyse over het effect van voeding en natuurlijke voedingssuppletie door drs. E.F.G. Woerlee.

Zeewier - eetbaar - heeft effect op niveau van oestrogeen bij vrouwen voor de overgang en beinvloedt lengte van menstruatiecyclus welke positief effect kan hebben op risico's van borst- en eierstokkanker.

Voeding en voedingstoffen bij borstkanker. Een aantal artikelen en studies over effecten van voeding en voedingstoffen als preventie of therapeutisch bij borstkanker bij elkaar gezet.

ORIGINAL REPORTS

Cancer Prevention and Control

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Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study

ABSTRACT

WFPB dietary - Whole Food Plant Based dietary changes during treatment for metastatic breast cancer are well tolerated and significantly improve weight, cardiometabolic and hormonal parameters. Longer studies are warranted to assess the durability of changes.

A whole-food, plant-based randomized controlled trial in metastatic breast cancer: weight, cardiometabolic, and hormonal outcomes

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