12 mei 2012: inmiddels wordt RFA - Radio frequency Ablation ook met de Ultra Sound techniek meer en meer toegepast. Zie voor meer recente informatie onder RFA - Radio Frequency Ablation informatie

 

31 mei 2006: Bron: 1: Br J Cancer. 2005 Oct 17;93(8):890-5.

Opereren van levertumoren en niertumoren met HIFU = High Dose Focused Ultrasound blijkt een veilig en met een beter resultaat, significante minder bijwerkingen, uit te voeren behandeling blijkt uit een gerandomiseerde fase II studie. Bij levertumoren werd een 100% verwijdering bereikt tegenover 67% bij niertumoren, maar ook in dit laatste geval nog beter dan bij andere traditionele operatieve technieken. Deze studie is gepubliceerd in het toonaangevende Britisch Journal of Cancer.

Als u hier klikt kunt u van onderstaande studie het volledige studie rapport gratis inzien. Onderaan dit artikel staat een referentielijst van studies gerelateerd aan HIFU - Ultra Sound en onderstaande studie

 

The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population

 Br J Cancer. 2005 October 17; 93(8): 890–895.
Published online 2005 September 27. doi:  10.1038/sj.bjc.6602803
PMCID: PMC2361666
The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population
R O Illing,1* J E Kennedy,1 F Wu,2 G R ter Haar,3 A S Protheroe,4 P J Friend,1 F V Gleeson,1 D W Cranston,1 R R Phillips,1 and M R Middleton4
1HIFU Unit, Churchill Hospital, Oxford OX3 7LJ, UK
2Clinical Center for Tumor Therapy, Chongqing University of Medical Sciences, People's Republic of China
3Institute of Cancer Research, Sutton, UK
4Cancer Research UK, Medical Oncology Unit, University of Oxford, Oxford, UK
*Author for correspondence: rowland@doctors.org.uk
Received May 3, 2005; Revised August 25, 2005; Accepted August 25, 2005.
High-intensity focused ultrasound (HIFU) provides a potential noninvasive alternative to conventional therapies. We report our preliminary experience from clinical trials designed to evaluate the safety and feasibility of a novel, extracorporeal HIFU device for the treatment of liver and kidney tumours in a Western population. The extracorporeal, ultrasound-guided Model-JC Tumor Therapy System (HAIFU™ Technology Company, China) has been used to treat 30 patients according to four trial protocols. Patients with hepatic or renal tumours underwent a single therapeutic HIFU session under general anaesthesia. Magnetic resonance imaging 12 days after treatment provided assessment of response. The patients were subdivided into those followed up with further imaging alone or those undergoing surgical resection of their tumours, which enabled both radiological and histological assessment. HIFU exposure resulted in discrete zones of ablation in 25 of 27 evaluable patients (93%). Ablation of liver tumours was achieved more consistently than for kidney tumours (100 vs 67%, assessed radiologically). The adverse event profile was favourable when compared to more invasive techniques. HIFU treatment of liver and kidney tumours in a Western population is both safe and feasible. These findings have significant implications for future noninvasive image-guided tumour ablation.
References
  • Blana A, Walter B, Rogenhofer S, Wieland WF. High-intensity focused ultrasound for the treatment of localized prostate cancer: 5-year experience. Urology. 2004;63:297–300. [PubMed]
  • den Brok MH, Sutmuller RP, van der Voort R, Bennink EJ, Figdor CG, Ruers TJ, Adema GJ. In situ tumor ablation creates an antigen source for the generation of antitumor immunity. Cancer Res. 2004;64:4024–4029. [PubMed]
  • Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR. Renal cell carcinoma: clinical experience and technical success with radio-frequency ablation of 42 tumors. Radiology. 2003;226:417–424. [PubMed]
  • Goldberg SN, Charboneau JW, Dodd GD, III, Dupuy DE, Gervais DA, Gillams AR, Kane RA, Lee FT, Jr, Livraghi T, McGahan JP, Rhim H, Silverman SG, Solbiati L, Vogl TJ, Wood BJ. Image-guided tumor ablation: proposal for standardization of terms and reporting criteria. Radiology. 2003;228:335–345. [PubMed]
  • Hill CR, Rivens IH, Vaughan MG, ter Haar G. Lesion development in focused ultrasound surgery: a general model. Ultrasound Med Biol. 1994;20:259–269. [PubMed]
  • Kennedy J. High intensity focused ultrasound in the treatment of solid tumours. Nat Rev Cancer. 2005;5:321–327. [PubMed]
  • Kennedy JE, Ter Haar GR, Cranston D. High intensity focused ultrasound: surgery of the future. Br J Radiol. 2003;76:590–599. [PubMed]
  • Kennedy JE, Wu F, Ter Haar GR, Gleeson FV, Phillips RR, Middleton MR, Cranston D. High-intensity focused ultrasound for the treatment of liver tumours. Ultrasonics. 2004;42:931–935. [PubMed]
  • Livraghi T, Giorgio A, Marin G, Salmi A, de Sio I, Bolondi L, Pompili M, Brunello F, Lazzaroni S, Torzilli G. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology. 1995;197:101–108. [PubMed]
  • Lynn JG, Zwemer RL, Chick AJ, Miller AG. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol. 1942;26:179–193.
  • Oosterhof GON, Cornel EB, Smits GAHJ, Debruyne FMJ, Schalken JA. Influence of high-intensity focused ultrasound on the development of metastases. Eur Urol. 1997;32:91–95. [PubMed]
  • Shibata T, Iimuro Y, Yamamoto Y, Maetani Y, Ametani F, Itoh K, Konishi J. Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy. Radiology. 2002;223:331–337. [PubMed]
  • Sotsky TK, Ravikumar TS. Cryotherapy in the treatment of liver metastases from colorectal cancer. Semin Oncol. 2002;29:183–191. [PubMed]
  • Stewart EA, Gedroyc WM, Tempany CM, Quade BJ, Inbar Y, Ehrenstein T, Shushan A, Hindley JT, Goldin RD, David M, Sklair M, Rabinovici J. Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol. 2003;189:48–54. [PubMed]
  • Vogl TJ, Straub R, Eichler K, Sollner O, Mack MG. Colorectal carcinoma metastases in liver: laser-induced interstitial thermotherapy: local tumor control rate and survival data. Radiology. 2004;230:450–458. [PubMed]
  • Wu F, Wang Z-B, Chen W-Z, Zou J-Z, Bai J, Zhu H, Li K-Q, Jin C-B, Xie F-L, Su H-B. Advanced hepatocellular carcinoma: treatment with high intensity focused ultrasound ablation combined with transcatheter arterial embolization. Radiology. 2005a;235:659–667. [PubMed]
  • Wu F, Wang ZB, Chen WZ, Zou JZ, Bai J, Zhu H, Li KQ, Xie FL, Jin CB, Su HB, Gao GW. Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience. Ultrasound Med Biol. 2004;30:245–260. [PubMed]
  • Wu F, Wang Z-B, Zhu H, Chen W-Z, Zou J-Z, Bai J, Li K-Q, Jin C-B, Xie F-L, Su H-B. Feasibility of ultrasound-guided high intensity focused ultrasound treatment in patients with advanced pancreatic cancer – initial experience. Radiology. 2005b;236:1034–1040. [PubMed]
  • Yang R, Reilly CR, Rescorla FJ, Sanghvi NT, Fry FJ, Franklin TD, Jr, Grosfeld JL. Effects of high-intensity focused ultrasound in the treatment of experimental neuroblastoma J Pediatr Surg 1992. 27246–250.250discussion 250–251. [PubMed]


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