20 november 2017: lees ook dit artikel: 

https://kanker-actueel.nl/hifu-high-intensity-focused-ultrasound-is-uitstekende-behandeling-voor-niet-uitgezaaide-prostaatkanker-waarom-blijft-dit-een-experimentele-behandeling-en-wordt-hifu-niet-vergoed-vanuit-basisverzekering.html

6 november 2017: De verwijzingen naar de studies in het UMC van zowel Ultra Sound (MR-HIFU) bij borstkanker als bij botuitzaaiingen bij prostaatkanker (zie hieronder) geven geen website pagina meer. De studie bij borstkanker is afgesloten, die bij botmetastases waarschijnlijk ook want vind deze niet meer op de website van het UMC Utrecht en ook niet meer in clinical trials.

Maar voor de studie bij borstkanker zie deze publicatie:Nieuw onderzoek toont potentie MR-HIFU technologie voor nieuwe kankertherapie waarin de studie met borstkanker is verwerkt. Zie ook in dit verband deze studie: Nicole Hijnen et al., Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound, (PNAS, 31 mei 2017).

Een studie van Ultra Sound (MR-HIFU) bij botuitzaaiingen van de Nederlandse onderzoekers betrokken bij onderstaand omschreven onderzoek bij prostaatkankerpatiënten is deze: Quality of MR thermometry during palliative MR-guided high-intensity focused ultrasound (MR-HIFU) treatment of bone metastases

Het volledige studierapport is gratis in te zien met gedetailleerde omschrijvingen van hoe Ultra Sound werkt en ook grafieken van behandelde patienten. En uitstekende referentielijst.

Onderaan dit artikel staat abstract plus referentielijst

13 augustus 2013: Bron: UMC Utrecht

HIFU bij prostaatkanker in muizen

Foto: behandeling van botmetastase in bot via HIFU

Wat veel mensen niet weten en waar patiënten ook zelden op wordt gewezen is deze studie in het UMC Utrecht die al enkele jaren loopt en waarvoor nog steeds patiënten worden aangenomen, zie ook meer info over HIFU in gerelateerde artikelen:

MR-HIFU bij pijnlijke botuitzaaiingen

UMC Utrecht

MR-HIFU (Magnetic Resonance Imaging-guided High Intensity Focused Ultrasound) is een nieuwe behandelmethode voor pijnlijke botuitzaaiingen. Het gaat om een behandeling, met het doel de pijn te verminderen en kwaliteit van leven te behouden of waar mogelijk te verbeteren. De behandeling wordt alleen toegepast bij patiënten in de palliatieve fase, dit wil zeggen dat zij met de reguliere behandelingen niet meer beter kunnen worden. MR-HIFU is goedgekeurd als veilige behandeling voor patiënten met pijnlijke botuitzaaiingen.

Op deze website in dit PDF document staat in het Engels beschreven hoe de MRI-HIFU werkt: Klik hier voor dit document.

HIFU werkingsmechanisme

Quality of MR thermometry during palliative MR-guided high-intensity focused ultrasound (MR-HIFU) treatment of bone metastases

  • Mie K LamEmail author,
  • Merel Huisman,
  • Robbert J Nijenhuis,
  • Maurice AAJ van den Bosch,
  • Max A Viergever,
  • Chrit TW Moonen and
  • Lambertus W Bartels
Journal of Therapeutic Ultrasound20153:5

https://doi.org/10.1186/s40349-015-0026-7

Received: 21 November 2014

Accepted: 7 March 2015

Published: 24 March 2015

Abstract

Background

Magnetic resonance (MR)-guided high-intensity focused ultrasound has emerged as a clinical option for palliative treatment of painful bone metastases, with MR thermometry (MRT) used for treatment monitoring. In this study, the general image quality of the MRT was assessed in terms of signal-to-noise ratio (SNR) and apparent temperature variation. Also, MRT artifacts were scored for their occurrence and hampering of the treatment monitoring.

Methods

Analyses were performed on 224 MRT datasets retrieved from 13 treatments. The SNR was measured per voxel over time in magnitude images, in the target lesion and surrounding muscle, and was averaged per treatment. The standard deviation over time of the measured temperature per voxel in MRT images, in the muscle outside the heated region, was defined as the apparent temperature variation and was averaged per treatment. The scored MRT artifacts originated from the following sources: respiratory and non-respiratory time-varying field inhomogeneities, arterial ghosting, and patient motion by muscle contraction and by gross body movement. Distinction was made between lesion type, location, and procedural sedation and analgesic (PSA).

Results

The average SNR was highest in and around osteolytic lesions (21 in lesions, 27 in surrounding muscle, n = 4) and lowest in the upper body (9 in lesions, 16 in surrounding muscle, n = 4). The average apparent temperature variation was lowest in osteolytic lesions (1.2°C, n = 4) and the highest in the upper body (1.7°C, n = 4). Respiratory time-varying field inhomogeneity MRT artifacts occurred in 85% of the datasets and hampered treatment monitoring in 81%. Non-respiratory time-varying field inhomogeneities and arterial ghosting MRT artifacts were most frequent (94% and 95%) but occurred only locally. Patient motion artifacts were highly variable and occurred less in treatments of osteolytic lesions and using propofol and esketamine as PSA.

Conclusions

In this study, the general image quality of MRT was observed to be higher in osteolytic lesions and lower in the upper body. Respiratory time-varying field inhomogeneity was the most prominent MRT artifact. Patient motion occurrence varied between treatments and seemed to be related to lesion type and type of PSA. Clinicians should be aware of these observed characteristics when interpreting MRT images.

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Copyright

© Lam et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


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