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3 april 2021: Bron: Nutrients

Wanneer vrouwen met eierstokkanker of kanker in het buikvlies (endometriosekanker) een kytogeen dieet - koolhydraatarm dieet volgen dan heeft dat een goed effect op de kwaliteit van leven. Het vergroot het lichamelijk functioneren, het verhoogt de energie, vermindert de vermoeidheid en vermindert ook het hongergevoel naar specifieke voedingsmiddelen. Dit blijkt uit een vergelijkende studie bij patiënten met eierstokkanker en kanker in het buikvlies (endometriosekanker), waarvan sommigen wel en anderen geen chemo kregen tijdens de studie. De verschillen waren statistisch significant op meting na 12 weken volgen van het dieet ongeacht of er wel of geen chemo werd ondergaan.

De onderzoekers vergeleken twee vormen van dieet met elkaar. het kytogene dieet ((veel energie uit vet (70%), energie uit eiwit (25%) en 5% uit koolhydraten) en een dieet zoals aanbevolen door de American Cancer Society ( vezelrijk, vetarm)

Table 1

Dietary guidelines for patients.

Kytogene DietACS diet
  • Avoid all grains, fruits, and starchy vegetables

  • Eat at least 2 cups leafy green vegetables and 1 cup non-starchy vegetables daily

  • Fat sources may include olive oil, coconut oil, avocados, butter, cream, mayonnaise, and small amounts of nuts

  • Limit full-fat cheese to 4 ounces per day

  • Permitted protein foods include (un-breaded) meat, poultry, fish, and eggs

  • Emphasize foods rich in sodium, potassium, and magnesium

  • Incorporate fruits and vegetables into meals and snacks as often as possible

  • Limit or avoid saturated fats from meats, cheeses, and margarines.

  • Small amounts of fat from avocados, vegetable oils, and nuts are permitted.

  • Eat an abundance of high-fiber foods, such as whole grains, beans, fruits, and vegetables

  • Consume foods with added sugar in moderation

In totaal werden 182 potentiële kandidaten gescreend op deelname aan dit onderzoek, 73 vrouwen werden gerandomiseerd (ACS: n = 36; KD: n = 37) en 45 vrouwen (ACS: n = 20; KD: n = 25) voltooiden hun toegewezen dieetinterventie van 12 weken. Na randomisatie schreven 16 vrouwen zich niet in vanwege planningsproblemen, en 6 vrouwen in elke dieetgroep (n = 12) trokken zich in de loop van het onderzoek terug vanwege planningsproblemen (n = 4), of niet langer wilden voldoen aan dieetwensen (n = 3), door terugkeer van kanker (n = 3) en door overlijden (n = 2). Van de 45 deelnemers die uiteindelijk het onderzoek voltooiden, was de gemiddelde leeftijd van de patiënten bij aanvang 60,2 jaar (31-79 jaar) en de gemiddelde BMI 31,7 kg / m2 (18,9-56,1 kg / m2).

De onderzoeksgroep bestond voornamelijk uit blanke vrouwen (87%), waarbij respectievelijk 11% en 2% uit Afro-Amerikaanse en Aziatische vrouwen bestond. Bij meer dan de helft (62%) was eierstokkanker vastgesteld, terwijl bij de overige 17 patiënten buikvlieskanker - endometriosekanker was vastgesteld.

Van de 45 deelnemers die het onderzoek voltooiden, kregen 11 (24%) gelijktijdig chemotherapie terwijl ze deze dieetinterventie ondergingen. Er waren geen significante verschillen tussen de dieetgroepen (KD vs. ACS) in leeftijd, BMI, raciale verdeling, kankertype, percentage dat gelijktijdig chemotherapie kreeg of tijd sinds de eerste diagnose van kanker. In totaal voltooiden 4 vrouwen met diabetes type 2 het onderzoek (ACS: n = 1; KD: n = 3).

Na 12 weken werden deze verschillen gemeten in zowel lichamelijke conditie als mentale conditie:

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Figure 1

(A) Physical component summary scores at 12 weeks by diet group and (B) mental component summary at 12 weeks. Values are adjusted means ± SEM. * Denotes a significant between-group difference (p < 0.05) from ACS arm by ANCOVA, using baseline values and chemotherapy status as covariates. ACS, n = 20; KD, n = 23.

De onderzoekers concluderen dat bij vrouwen met eierstok- of endometriumkanker een Ketogeen dieet de kwaliteit van leven niet vermindert; het kan inderdaad de fysieke functie verbeteren, de energie verhogen en het hunkeren naar specifiek voedsel verminderen. Deze bevindingen kunnen generaliseren naar andere kankers die verband houden met obesitas, zoals vormen van darmkanker of postmenopauzale borstkanker. Er is echter verder onderzoek nodig om te bepalen voor welke kankertypes en behandelingsregimes een Ketogeen dieet het meest geschikt kan zijn en om te onderzoeken hoe een langdurige Ketogeen dieet het dagelijkse leven van kankerpatiënten kan beïnvloeden.

Het studierapport is gratis en volledig te downloaden of in te zien met veel meer grafieken enz.. Hier het abstract met referentielijst. 

Randomized Controlled Trial
 
2018 Aug 30;10(9):1187.
 doi: 10.3390/nu10091187.

Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial

Affiliations 
Free PMC article

Abstract

Ketogenic diets (KDs) are gaining attention as a potential adjuvant therapy for cancer, but data are limited for KDs' effects on quality of life. We hypothesized that the KD would (1) improve mental and physical function, including energy levels, (2) reduce hunger, and (3) diminish sweet and starchy food cravings in women with ovarian or endometrial cancer. Participants were randomized to a KD (70:25:5 energy from fat, protein, and carbohydrate) or the American Cancer Society diet (ACS: high-fiber, lower-fat). Questionnaires were administered at baseline and after 12 weeks on the assigned diet to assess changes in mental and physical health, perceived energy, appetite, and food cravings. We assessed both between-group differences and within-group changes using ANCOVA and paired t-tests, respectively. After 12 weeks, there was a significant between-group difference in adjusted physical function scores (p < 0.05), and KD participants not receiving chemotherapy reported a significant within-group reduction in fatigue (p < 0.05). There were no significant between-group differences in mental function, hunger, or appetite. There was a significant between-group difference in adjusted cravings for starchy foods and fast food fats at 12 weeks (p < 0.05 for both), with the KD group demonstrating less frequent cravings than the ACS. In conclusion, in women with ovarian or endometrial cancer, a KD does not negatively affect quality of life and in fact may improve physical function, increase energy, and diminish specific food cravings. This trial was registered at ClinicalTrials.gov as NCT03171506.

Keywords: endometrial cancer; fatigue; food cravings; ketogenic diet; mental function; ovarian cancer; physical function; quality of life.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

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