14 juli 2021: Bron:  2021 Apr; 13(4): 1241

Uit een 18 jaar durende studie blijkt dat dagelijks een kop koffie de kans op overlijden door alle oorzaken met 27% kan verminderen. Bij meer dan 1 kopje was dat zelfs 44%. Uit eerdere onderzoekers blijkt dat deze resultaten in overeenstemming zijn met wat eerder is gevonden. Zie ook paar artikelen op onze site daarover.

Waarom koffie zo goed zou zijn is nog niet duidelijk. Onderzoekers denken dat dit komt omdat koffie veel antioxidanten bevat of een gunstig effect op het microbioom van de darmen heeft. Uit dit recente onderzoek blijkt wel dat je ook weer niet teveel koffie moet drinken want al bij dagelijks 3 – 4 koppen koffie blijkt het geen voordeel meer op te leveren maar eerder een nadeel.  De hoeveelheid ligt dus wel gevoelig.

De onderzoekers gebruikten gegevens over koffieconsumptie en andere persoonlijke variabelen, en het aantal sterfgevallen gedurende een follow-up periode van 18 jaar, voor 1567 deelnemers van 20 jaar en ouder uit de Valencia Nutrition Study in Spanje.

De totale consumptie van koffie, cafeïnehoudende koffie en cafeïnevrije koffie werd bepaald met behulp van een erkende voedselfrequentievragenlijst. Gedurende de 18-jarige follow-up periode overleden 317 personen, waarvan 115 aan hart- en vaatziektes en 82 aan kanker. Vergeleken met geen consumptie, was de consumptie van dagelijks 1 kop koffie en meer dan 1 kop koffie per dag geassocieerd met een lager risico van sterfte aan alle oorzaken, HR = 0,73 (95% CI: 0,56-0,97) en HR 0,56 (95% CI: 0,41-0,77), respectievelijk.

Een lagere kankersterfte werd waargenomen bij drinkers van meer dan 1 kopje per dag vergeleken met niet-drinkers, HR 0,41 (95% CI 0,20-0,86). Wat het type koffie betreft, was alleen de algemene consumptie van cafeïnehoudende koffie geassocieerd met een lagere sterfte aan alle oorzaken na 12 en 18 jaar follow-up, HR = 0,66 (95% CI: 0,46-0,94) en HR = 0,59 (95% CI: 0,44-0,79), respectievelijk. 

Conclusie van de onderzoekers:

Deze studie suggereert dat een matige consumptie van koffie, met name van cafeïnehoudende koffie geassocieerd is met een lagere sterfte aan alle oorzaken en kanker na een lange follow-up periode. (bereik 1-6,5 kopjes per dag)

Het studierapport is gratis in te zien. Hier het abstract van de studie:


We assessed the association between usual coffee consumption and all-cause, cardiovascular (CV), and cancer mortality in an adult population in Spain, taking into account both the amount and type of coffee consumed. We used baseline data on coffee consumption and other personal variables, and the number of deaths during an 18-year follow-up period, for 1567 participants aged 20 years and older from the Valencia Nutrition Study in Spain. Total, caffeinated, and decaffeinated coffee consumption was assessed using a validated food frequency questionnaire. Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). During the 18-year follow-up period, 317 died; 115 due to CV disease and 82 due to cancer. Compared with no-consumption, the consumption of ≤1 cup per day and >1 cup per day of coffee was associated with a lower risk of all-cause mortality, HR = 0.73 (95% CI: 0.56–0.97) and HR 0.56 (95% CI: 0.41–0.77), respectively. A lower cancer mortality was observed among drinkers of more than 1 cup per day compared with nondrinkers, HR 0.41 (95% CI 0.20–0.86). Regarding the type of coffee, only the overall consumption of caffeinated coffee was associated with lower all-cause mortality at 12 and 18 years of follow-up, HR = 0.66 (95% CI:0.46–0.94) and HR = 0.59 (95% CI: 0.44–0.79), respectively.

In conclusion, this study suggests that the moderate consumption of coffee, particularly caffeinated coffee (range 1–6.5 cups per day), is associated with a lower all-cause and cancer mortality after a long follow-up period. No significant association was found between coffee consumption and CVD mortality.

5. Conclusions

In conclusion, this study suggests that the moderate consumption of coffee, particularly caffeinated coffee (range 1–6.5 cups per day), is associated with a lower all-cause and cancer mortality after a long follow-up period. These findings are consistent with previous studies, although they add new evidence from a Mediterranean adult population. Thus, coffee consumption could be promoted as part of a healthy Mediterranean lifestyle, although further long-term longitudinal studies collecting information on the amount and type of coffee should add valuable information regarding its beneficial effects.


The authors thank the VNS participants for their valuable contribution to this research. We appreciate the English revision of the manuscript made by Jessica Gorlin.

Author Contributions

Conceptualization, J.V. and M.G.-d.l.H.; formal analysis, L.T.-C.; data curation, L.T.-C. and J.V.; writing—original draft preparation, L.T.-C.; writing—review and editing, L.T.-C., L.M.C.-G., S.G.-P., L.N.-B., and A.O.-C.; supervision, J.V. and M.G.-d.l.H. All authors have read and agreed to the published version of the manuscript.


The VNS study was supported by a grant from the Dirección General de Salud Pública, Generalitat Valenciana 1994 and the Fondo Investigacion Sanitaria (FIS 00/0985). This study has also received support from the Instituto de Salud Carlos III and FEDER funds (FIS PI13/00654).

Institutional Review Board Statement

The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the local Ethical Committees of the Hospital of San Juan and the Miguel Hernandez University.

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

The data presented in this study are available on request from the corresponding author. The data are not publicly available due to confidentiality and ethical reasons.

Conflicts of Interest

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.


Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.


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1 Reactie op "Koffie bevordert gezondheid en enkele koppen per dag vermindert risico op sterfte door alle oorzaken met 27 procent. Blijkt uit grote langjarige studie"

  • teun :
    het lijkt mij erg sterk wand koffie verzuurt en kanker cellen leven graag in een verzuurde omgeving

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