16 januari 2012: bron: PLoS One. 2011;6(6):e19881. Epub 2011 Jun 16.

De afgelopen weken is wereldwijd grote beroering ontstaan door fraude van een wetenschapper, Dr. Dipak Das,  met een studie met resveratrol. En daarmee komt resveratrol ook in een dubieus daglicht te staan. Echter een overzichtstudie afgelopen jaar liet nog eens zien dat resveratrol wel degelijk eigenschappen heeft die kunnen helpen kanker te bestrijden c.q. te voorkomen. Klik hier voor een studie abstract over effect van resveratrol bij prostaatkanker. Hier het abstract van de overzichtsstudie, maar als u hier klikt kunt u het volledige studierapport gratis inzien . Onderaan dit artikel staat een referentielijst van 144 studies gedaan met resveratrol. De studies van Dr. Dipak Das uit de lijst zijn dus bljikbaar gemanipuleerd.

What is new for an old molecule? Systematic review and recommendations on the use of resveratrol

PLoS One. 2011; 6(6): e19881.
Published online 2011 June 16. doi:  10.1371/journal.pone.0019881
PMCID: PMC3116821
Copyright This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol
Ole Vang,1* Nihal Ahmad,2 Clifton A. Baile,3 Joseph A. Baur,4 Karen Brown,5 Anna Csiszar,6 Dipak K. Das,7 Dominique Delmas,8 Carmem Gottfried,9 Hung-Yun Lin,10 Qing-Yong Ma,11 Partha Mukhopadhyay,12 Namasivayam Nalini,13 John M. Pezzuto,14 Tristan Richard,15 Yogeshwer Shukla,16 Young-Joon Surh,17 Thomas Szekeres,18 Tomasz Szkudelski,19 Thomas Walle,20 and Joseph M. Wu21
1Department of Science, System and Models, Roskilde University, Roskilde, Denmark
2Department of Dermatology, University of Wisconsin, Madison, Wisconsin, United States of America
3Department of Animal and Dairy Science, University of Georgia, Athens, Georgia, United States of America
4Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
5Department of Cancer Studies and Molecular Medicine, The Biocentre, University of Leicester, Leicester, Great Britain, United Kingdom
6Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
7Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut, United States of America
8INSERM U866, University of Burgundy, Dijon, France
9Department of Biochemistry, Postgraduate Programme of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
10Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America
11Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China
12Laboratory of Physiological Studies, Section on Oxidative Stress Tissue Injury, National Institutes of Health, Rockville, Maryland, United States of America
13Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India
14College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii, United States of America
15UFR Pharmacie, University of Bordeaux, Villenave d'Ornon, France
16Proteomics Laboratory, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India
17College of Pharmacy, Seoul National University, Seoul, South Korea
18Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
19Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Poznan, Poland
20Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, United States of America
21Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, United States of America
Jose Vina, Editor
University of Valencia, Spain
* E-mail: ov@ruc.dk
Conceived and designed the experiments: OV. Analyzed the data: OV NA CAB JAB KB AC DKD DD CG H-YL Q-YM PM NN JMP TR YS Y-JS T. Szekeres T. Szkudelski TW JMW. Wrote the paper: OV. Evaluation of the cancer preventive effect: NA KB H-YL NN JMP YS T. Szekeres. Evaluation of the CHD preventive effect: DKD PM JMW. Evaluation of the obesity/diabetes effect: CAB T. Szkudelski. Evaluation of the anti-aging/anti-inflammatory effect: JAB AC Q-YM. Evaluation of the neuroprotective effect: CG TR. Metabolism and pharmacokinetic of resveratrol: DD TW.
Received January 21, 2011; Accepted April 6, 2011.
Abstract
Background
Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark.
Methodology
Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed “side effects” caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented?
Conclusions/Significance
The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.
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