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30 april 2019: Oncotarget december 2018

Een reviewstudie gepubliceerd december 2018 in Oncotarget: Green tea extract for prevention of prostate cancer progression in patients on active surveillance bewijst dat een groene thee extract van grote waarde kan zijn voor prostaatkankerpatiënten die op een wait-and-see programma zitten. Lees het studierapport. (Abstract en referentielijst staat onderaan artikel

Ook een nieuwe kleinschalige studie bewijst dat een groene thee extract de PSA kan doen dalen bij prostaatkankerpatienten. Omdat de studie met slechts 44 patienten (22 vs 22) gerandomiseerd werd uitgevoerd was het verschil niet statistisch significant. Hoewel in de groene thee groep de PSA waarden op 6 maanden en 12 maanden bij  de patienten beduidend lager waren dan in de placebogroep.  

Lees het volledige studierapport: Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial in PDF formaat.

30 april 2019: lees ook dit artikel: 

https://kanker-actueel.nl/groene-thee-en-in-het-bijzonder-egcg-in-relatie-tot-gezondheid-en-ziekte-waaronder-kanker-een-review-van-arts-bioloog-drs-engelbert-valstar-aan-de-hand-van-de-literatuur.html

Systematically evaluating the effectiveness and safety of novel agents such as green tea catechins, which have been well characterized in laboratory and early phase clinical trials, may inform the development of phase III clinical trials and ultimately provide strategies for chemoprevention in men on active surveillance for prostate cancer, for whom, currently, there are no options for reducing their risk.

. 2018 Dec 28; 9(102): 37798–37806.
Published online 2018 Dec 28. doi: 10.18632/oncotarget.26519
PMCID: PMC6340872
PMID: 30701033

Green tea extract for prevention of prostate cancer progression in patients on active surveillance

Abstract

Background

Active surveillance (AS) has evolved as a management strategy for men with low grade prostate cancer (PCa). However, these patients report anxiety, doubts about the possible progression of the disease as well as higher decisional conflict regarding selection of active surveillance, and have been reported to ultimately opt for treatment without any major change in tumor characteristics. Currently, there is a paucity of research that systematically examines alternate strategies for this target population.

Methods

We conducted a review the evidence from epidemiological, in vitro, preclinical and early phase trials that have evaluated green tea catechins (GTC) for secondary chemoprevention of prostate cancer, focused on men opting for active surveillanceof low grade PCa.

Results

Results of our review of the in vitro, preclinical and phase I-II trials, demonstrates that green tea catechins (GTC) can modulate several relevant intermediate biological intermediate endpoint biomarkers implicated in prostate carcinogenesis as well as clinical progression of PCa, without major side effects.

Discussion

Although clinical trials using GTC have been evaluated in early phase trials in men diagnosed with High-Grade Prostatic Intraepithelial Neoplasia, Atypical Small Acinar Proliferation and in men with localized disease before prostatectomy, the effect of GTC on biological and clinical biomarkers implicated in prostate cancer progression have not been evaluated in this patient population.

Conclusion

Results of these studies promise to provide a strategy for secondary chemoprevention, reduce morbidities due to overtreatment and improve quality of life in men diagnosed with low-grade PCa.

Footnotes

CONFLICTS OF INTEREST

None of the authors have any potential or competing interests.

FUNDING

This is supported by National Institute of Health Grant 5P30CA076292-20.

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