Aan dit artikel is enkele uren gewerkt. Opzoeken, vertalen, plaatsen enz. Als u ons wilt ondersteunen dan kan dat via een al of niet anonieme donatie. Elk bedrag is welkom hoe klein ook. Klik hier als u ons wilt helpen kanker-actueel online te houden. Wij zijn een ANBI organisatie dus in principe is uw donatie aftrekbaar voor de belasting.

17 mei 2012:  Bron: Am J Med 2012.

Mensen die regelmatig vis eten zouden daarmee het risico op ontwikkelen van darmkanker en vooral endeldarmkanker - rectumkanker verkleinen. Aldus de resultaten uit een meta analyse van 41 cohortstudies en case control studies in de periode van 1990 tot 2011. De studie is uitgevoerd door onderzoekers van de University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School.
De onderzoekers tekenen er wel bij aan dat niet duidelijk is of mensen die reeds regelmatig vis eten nog wel gebaat zouden zijn met nog meer vis eten. Verder heeft de studie alleen het effect onderzocht van het eten van verse vis en niet van visolie capsules bv. Ook is onduidelijk of een bepaalde leefstijl en andere gezonde gewoontes invloed hebben op het voordeel van vis eten. Uit de studie komt wel naar voren dat wie veel rood vlees of bewerkt vlees eet het ontwikkelen van kanker kan bevorderen. Maar dat is al heel lang duidelijk, zie onder rood vlees schadelijk voor gezondheid. Wie dus gewend is veel rood vlees te eten kan met een vermindering daarvan en regelmatig, zeg twee keer per week, een verse vis daarvoor in de plaats neemt, de kans op ontwikkelen van darmkanker echt verminderen. Die vis moet dan niet op de barbeque of grill gebakken worden want dan schijnt het effect te niet gedaan te worden, aldus de onderzoekers.

In de studie wordt gecorrigeerd naar leeftijd, alcohol, erfelijkheid en andere risico factoren een significant verschil van 12% gevonden voor het risico op het ontwikkelen van alle vormen van darmkanker. Uitgesplitst naar hoogste en laagste gebruik van verse vis blijkt voor dikke darmkanker het verschil 4%, voor rectumkanker - endeldarmkanker blijkt dat verschil 21% te zijn.
De onderzoekers vermoeden dat de Omega-3 vetzuren  hiervoor verantwoordelijk kunnen zijn, maar zeggen er wel bij dat hun studiegegevens dit niet bewijzen. ook bewijst de studie niet dat visolie capsules hetzelfde effect zouden hebben dan het eten van verse vis, dat was geen studiedoel van deze meta analyse. Wie in de artikeln in linkerkolom klikt ziet dat ook visolie capsules wel degelijk een groot effect hebben op onze gezondheid. Klik hier voor recepten met verse vis

Als u hier klikt kunt U het volledige studierapport tegen betaling inzien. Hier het abstract van de studie. Onderaan 89 referenties van studies gerelateerd aan deze meta analyse

Meta-analysis suggest that fish consumption is inversely associated with colorectal cancer

Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis

  • Shengjun Wu

      Affiliations

    • Department of Psychology, Fourth Military Medical University, Xi'an, China
    • SW, BF and KL contributed equally to this article.
    • ,
  • Bin Feng

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • SW, BF and KL contributed equally to this article.
    • ,
  • Kai Li

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • ,
  • Xia Zhu

      Affiliations

    • Department of Psychology, Fourth Military Medical University, Xi'an, China
    • ,
  • Shuhui Liang

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • ,
  • Xufeng Liu

      Affiliations

    • Department of Psychology, Fourth Military Medical University, Xi'an, China
    • ,
  • Shuang Han

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • ,
  • Biaoluo Wang

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • ,
  • Kaichun Wu

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • ,
  • Danmin Miao

      Affiliations

    • Department of Psychology, Fourth Military Medical University, Xi'an, China
    • ,
  • Jie Liang

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • SW, BF and KL contributed equally to this article.
    • ,
  • Daiming Fan

      Affiliations

    • State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
    • Corresponding Author InformationRequests for reprints should be addressed to Jie Liang or Daiming Fan, 127 West Chang-Le Road, Xi'an, Shaanxi, 710032, China

published online 18 April 2012.
Corrected Proof

Abstract 

Background

Fish consumption may protect against colorectal cancer, but results from observational studies are inconsistent; therefore, a systematic review with a meta-analysis was conducted.

Methods

Relevant studies were identified by a search of MEDLINE and EMBASE databases to May 2011, with no restrictions. Reference lists from retrieved articles also were reviewed. Studies that reported odds ratio (OR) or relative risk estimates with 95% confidence intervals (CIs) for the association between the consumption of fish and the risk of colorectal, colon, or rectal cancer were included. Two authors independently extracted data and assessed study quality. The risk estimate (hazard ratio, relative risk, or OR) of the highest and lowest reported categories of fish intake were extracted from each study and analyzed using a random-effects model.

Results

Twenty-two prospective cohort and 19 case-control studies on fish consumption and colorectal cancer risk met the inclusion criteria and were included in the meta-analysis. Our analysis found that fish consumption decreased the risk of colorectal cancer by 12% (summary OR, 0.88; 95% CI, 0.80-0.95). The pooled ORs of colorectal cancer for the highest versus lowest fish consumption in case-control studies and cohort studies were 0.83 (95% CI, 0.72-0.95) and 0.93 (95% CI, 0.86-1.01), respectively. There was heterogeneity among case-control studies (P<.001) but not among cohort studies. A significant inverse association was found between fish intake and rectal cancer (summary OR, 0.79; 95% CI, 0.65-0.97), and there was a modest trend seen between fish consumption and colon cancer (summary OR, 0.96; 95% CI, 0.81-1.14). This study had no publication bias.

Conclusion

Our findings from this meta-analysis suggest that fish consumption is inversely associated with colorectal cancer.

References 

  1. Parkin DM , Bray F , Ferlay J , et al.  Global cancer statistics, 2002 . CA Cancer J Clin . 2005;55:74–108
  2. National Cancer Institute. 2009 . http://www.cancer.gov/cancertopics/commoncancers Accessed January 27, 2012
  3. Nisa H , Kono S , Yin G , et al.  Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study . BMC Cancer . 2010;10:274
  4. Rehm J , Baliunas D , Borges GL , et al.  The relation between different dimensions of alcohol consumption and burden of disease: an overview . Addiction . 2010;105:817–843
  5. Larsson SC , Orsini N , Wolk A . Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies . JAMA . 2010;303:1077–1083
  6. World Cancer Research Fund/American Institute for Cancer Research . Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective . Washington DC: American Institute for Cancer Research; 2007;
  7. Kune GA , Bannerman S , Watson LF . Attributable risk for diet, alcohol, and family history in the Melbourne Colorectal Cancer Study . Nutr Cancer . 1992;18:231–235
  8. Albanes D , Virtamo J . Diet and risk of colorectal cancer in a cohort of Finnish men . Cancer Causes and Control . 1999;10:387–396
  9. Mikoczy Z , Rylander L . Mortality and cancer incidence in cohorts of Swedish fishermen and fishermen's wives: updated findings . Chemosphere . 2009;74:938–943
  10. Kato I , Akhmedkhanov A , Koenig K , et al.  Prospective study of diet and female colorectal cancer: the New York University Women's Health Study . Nutr Cancer . 1997;28:276–281
  11. Norat T , Bingham S , Ferrari P , et al.  Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition . J Natl Cancer Inst . 2005;97:906–916
  12. Tiemersma EW , Kampman E , Bueno de Mesquita HB , et al.  Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study . Cancer Causes Control . 2002;13:383–393
  13. Benito E , Obrador A , Stiggelbout A , et al.  A population-based case-control study of colorectal cancer in Majorca (I. Dietary factors) . Int J Cancer . 1990;45:69–76
  14. Bidoli E , Franceschi S , Talamini R , et al.  Food consumption and cancer of the colon and rectum in north-eastern Italy . Int J Cancer . 1992;50:223–229
  15. Peters RK , Pike M , Garabrant D , et al.  Diet and colon cancer in Los Angeles County, California . Cancer Causes Control . 1992;3:457–473
  16. Kampman E , Verhoeven D , Sloots L , et al.  Vegetable and animal products as determinants of colon cancer risk in Dutch men and women . Cancer Causes Control . 1995;6:225–234
  17. Daniel CR , McCullough ML , Patel RC , et al.  Dietary intake of omega-6 and omega-3 fatty acids and risk of colorectal cancer in a prospective cohort of U.S. men and women . Cancer Epidemiol Biomarkers Prev . 2009;18:516–525
  18. Bathen TF , Holmgren K , Lundemo AG , et al.  Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice . Anticancer Res . 2008;28:3717–3723
  19. van Beelen VA , Spenkelink B , Mooibroek H , et al.  An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats . Food Chem Toxicol . 2009;47:316–320
  20. Larsson SC , Kumlin M , Ingelman-Sundberg M , et al.  Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms . Am J Clin Nutr . 2004;79:935–945
  21. Reddy BS . Omega-3 fatty acids in colorectal cancer prevention . Int J Cancer . 2004;112:1–7
  22. Habermann N , Schön A , Lund EK , et al.  Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo . Apoptosis . 2010;15:621–630
  23. Caygill CP , Charlett A , Hill MJ . Fat, fish, fish oil and cancer . Br J Cancer . 1996;74:159–164
  24. Geelen A , Schouten JM , Kamphuis C , et al.  Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies . Am J Epidemiol . 2007;166:1116–1125
  25. Hall MN , Chavarro JE , Lee IM , et al.  A 22-year prospective study of fish, n-3 fatty acid intake, and colorectal cancer risk in men . Cancer Epidemiol Biomarkers Prev . 2008;17:1136–1143
  26. Jedrychowski W , Maugeri U , Pac A , et al.  Protective effect of fish consumption on colorectal cancer risk (Hospital-based case-control study in Eastern Europe) . Ann Nutr Metab . 2008;53:295–302
  27. Pauwels EK , Kairemo K . Fatty acid facts, part II: role in the prevention of carcinogenesis, or, more fish on the dish? . Drug News Perspect . 2008;21:504–510
  28. Huxley RR , Ansary-Moghaddam A , Clifton P , et al.  The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence . Int J Cancer . 2009;125:171–180
  29. Sharma S , Iwasaki M , Kunieda C , et al.  Development of a quantitative food frequency questionnaire for assessing food, nutrient, and heterocyclic aromatic amines intake in Japanese Brazilians for a colorectal adenoma case-control study . Int J Food Sci Nutr . 2009;60(Suppl 7):128–139
  30. Williams CD , Satia JA , Adair LS , et al.  Dietary patterns, food groups, and rectal cancer risk in Whites and African-Americans . Cancer Epidemiol Biomarkers Prev . 2009;18:1552–1561
  31. Nayak SP , Sasi MP , Sreejayan MP , et al.  A case-control study of roles of diet in colorectal carcinoma in a South Indian Population . Asian Pac J Cancer Prev . 2009;10:565–568
  32. Sugawara Y , Kuriyama S , Kakizaki M , et al.  Fish consumption and the risk of colorectal cancer: the Ohsaki Cohort Study . Br J Cancer . 2009;101:849–854
  33. Ganesh B , Talole SD , Dikshit R . A case-control study on diet and colorectal cancer from Mumbai, India . Cancer Epidemiol . 2009;33:189–193
  34. Bosetti C , Pelucchi C , La Vecchia C . Diet and cancer in Mediterranean countries: carbohydrates and fats . Public Health Nutr . 2009;12:1595–1600
  35. Béjar L , Gili M , Díaz V , et al.  Incidence and mortality by colorectal cancer in Spain during 1951-2006 and its relationship with behavioural factors . Eur J Cancer Prev . 2009; Sep 11. [Epub ahead of print]
  36. Pot GK , Majsak-Newman G , Geelen A , et al.  FISHGASTRO Study Group (Fish consumption and markers of colorectal cancer risk: a multicenter randomized controlled trial) . Am J Clin Nutr . 2009;90:354–361
  37. Pot GK , Habermann N , Majsak-Newman G , et al.  Increasing fish consumption does not affect genotoxicity markers in the colon in an intervention study . Carcinogenesis . 2010;31:1087–1091
  38. Yee YK , Tan VP , Chan P , et al.  Epidemiology of colorectal cancer in Asia . J Gastroenterol Hepatol . 2009;24:1810–1816
  39. Béjar Prado LM , Gili M , Ramírez G , et al.  Dietary changes and colorectal cancer trends in Spain during 1951-2007 . Rev Esp Enferm Dig . 2010;102:159–168
  40. Spencer EA , Key TJ , Appleby PN , et al.  Meat, poultry and fish and risk of colorectal cancer: pooled analysis of data from the UK dietary cohort consortium . Cancer Causes Control . 2010;21:1417–1425
  41. Bostick RM , Potter JD , Kushi LH , et al.  Sugar, meat, and fat intake, and non-dietary risk factors for colon cancer incidence in Iowa women (United States) . Cancer Causes Control . 1994;5:38–52
  42. Busstra MC , Siezen CL , Grubben MJ , et al.  Tissue levels of fish fatty acids and risk of colorectal adenomas: a case-control study (Netherlands) . Cancer Causes Control . 2003;14:269–276
  43. Chiu BC , Ji BT , Dai Q , et al.  Dietary factors and risk of colon cancer in Shanghai, China . Cancer Epidemiol Biomarkers Prev . 2003;12:201–208
  44. Diergaarde B , Tiemersma EW , Braam H , et al.  Dietary factors and truncating APC mutations in sporadic colorectal adenomas . Int J Cancer . 2005;113:126–132
  45. Engeset D , Andersen V , Hjartåker A , et al.  Consumption of fish and risk of colon cancer in the Norwegian Women and Cancer (NOWAC) study . Br J Nutr . 2007;98:576–582
  46. English DR , MacInnis RJ , Hodge AM , et al.  Red meat, chicken, and fish consumption and risk of colorectal cancer . Cancer Epidemiol Biomarkers Prev . 2004;13:1509–1514
  47. Fernandez E , Chatenoud L , La Vecchia C , et al.  Fish consumption and cancer risk . Am J Clin Nutr . 1999;70:85–90
  48. Franceschi S , Favero A . The role of energy and fat in cancers of the breast and colon-rectum in a southern European population . Ann Oncol . 1999;10(Suppl 6):61–63
  49. Gaard M , Tretli S , Løken EB . Dietary factors and risk of colon cancer: a prospective study of 50,535 young Norwegian men and women . Eur J Cancer Prev . 1996;5:445–454
  50. Giovannucci E , Rimm EB , Stampfer MJ , et al.  Intake of fat, meat, and fiber in relation to risk of colon cancer in men . Cancer Res . 1994;54:2390–2397
  51. Hsing AW , McLaughlin JK , Chow WH , et al.  Risk factors for colorectal cancer in a prospective study among U.S. white men . Int J Cancer . 1998;77:549–553
  52. Hu J , La Vecchia C , DesMeules M , et al.  Canadian Cancer Registries Epidemiology Research Group (Meat and fish consumption and cancer in Canada) . Nutr Cancer . 2008;60:313–324
  53. Iscovich JM , L'Abbé KA , Castelleto R , et al.  Colon cancer in Argentina (I: Risk from intake of dietary items) . Int J Cancer . 1992;51:851–857
  54. Kampman E , Slattery ML , Bigler J , et al.  Meat consumption, genetic susceptibility, and colon cancer risk: a United States multicenter case-control study . Cancer Epidemiol Biomarkers Prev . 1999;8:15–24
  55. Kato I , Tominaga S , Matsuura A , et al.  A comparative case-control study of colorectal cancer and adenoma . Jpn J Cancer Res . 1990;81:1101–1108
  56. Khan MM , Goto R , Kobayashi K , et al.  Dietary habits and cancer mortality among middle aged and older Japanese living in Hokkaido, Japan by cancer site and sex . Asian Pac J Cancer Prev . 2004;5:58–65
  57. Kimura Y , Kono S , Toyomura K , et al.  Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study . Cancer Sci . 2007;98:590–597
  58. Knekt P , Järvinen R , Dich J , et al.  Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N-nitroso compounds: a follow-up study . Int J Cancer . 1999;80:852–856
  59. Kojima M , Wakai K , Tamakoshi K , et al.  Japan Collaborative Cohort Study Group (Diet and colorectal cancer mortality: results from the Japan Collaborative Cohort Study) . Nutr Cancer . 2004;50:23–32
  60. Larsson SC , Rafter J , Holmberg L , et al.  Red meat consumption and risk of cancers of the proximal colon, distal colon and rectum: the Swedish Mammography Cohort . Int J Cancer . 2005;113:829–834
  61. Le Marchand L , Wilkens LR , Hankin JH , et al.  A case-control study of diet and colorectal cancer in a multiethnic population in Hawaii (United States): lipids and foods of animal origin . Cancer Causes Control . 1997;8:637–648
  62. Lee SA , Shu XO , Yang G , et al.  Animal origin foods and colorectal cancer risk: a report from the Shanghai Women's Health Study . Nutr Cancer . 2009;61:194–205
  63. Lüchtenborg M , Weijenberg MP , de Goeij AF , et al.  Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands) . Cancer Causes Control . 2005;16:1041–1054
  64. Ma J , Giovannucci E , Pollak M , et al.  Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men . J Natl Cancer Inst . 2001;93:1330–1336
  65. Pietinen P , Malila N , Virtanen M , et al.  Diet and risk of colorectal cancer in a cohort of Finnish men . Cancer Causes Control . 1999;10:387–396
  66. Ramadas A , Kandiah M . Food intake and colorectal adenomas: a case-control study in Malaysia . Asian Pac J Cancer Prev . 2009;10:925–932
  67. Sanjoaquin MA , Appleby PN , Thorogood M , et al.  Nutrition, lifestyle and colorectal cancer incidence: a prospective investigation of 10998 vegetarians and non-vegetarians in the United Kingdom . Br J Cancer . 2004;90:118–121
  68. Steinmetz KA , Potter JD . Food-group consumption and colon cancer in the Adelaide Case-Control Study (II. Meat, poultry, seafood, dairy foods and eggs) . Int J Cancer . 1993;53:720–727
  69. Willett WC , Stampfer MJ , Colditz GA , et al.  Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women . N Engl J Med . 1990;323:1664–1672
  70. Yang CX , Takezaki T , Hirose K , et al.  Fish consumption and colorectal cancer: a case-reference study in Japan . Eur J Cancer Prev . 2003;12:109–115
  71. Zhang B , Li X , Nakama H , et al.  A case-control study on risk of changing food consumption for colorectal cancer . Cancer Invest . 2002;20:458–463
  72. Brink M , Weijenberg MP , de Goeij AF , et al.  Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study . Br J Cancer . 2005;92:1310–1320
  73. Diergaarde B , van Geloof WL , van Muijen GN , et al.  Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study . Carcinogenesis . 2003;24:283–290
  74. Franceschi S , Favero A , La Vecchia C , et al.  Food groups and risk of colorectal cancer in Italy . Int J Cancer . 1997;72:56–61
  75. Goldbohm RA , van den Brandt PAvan't Veer P , et al.  A prospective cohort study on the relation between meat consumption and the risk of colon cancer . Cancer Res . 1994;54:718–723
  76. Inoue M , Tajima K , Hirose K , et al.  Subsite-specific risk factors for colorectal cancer: a hospital-based case-control study in Japan . Cancer Causes Control . 1995;6:14–22
  77. DerSimonian R , Laird N . Meta-analysis in clinical trials . Control Clin Trials . 1986;7:177–188
  78. Higgins JP , Thompson SG , Deeks JJ , et al.  Measuring inconsistency in meta-analyses . BMJ . 2003;327:557–560
  79. Hedges LV , Pigott TD . The power of statistical tests in meta-analysis . Psychol Method . 2001;6:203–217
  80. Thornton A , Lee P . Publication bias in meta-analysis: its causes and consequences . J Clin Epidemiol . 2000;53:207–216
  81. Egger M , Davey Smith G , et al.  Bias in meta-analysis detected by a simple, graphical test . BMJ . 1997;315:629–634
  82. Li M , Li JY , Zhao AL , et al.  Colorectal cancer or colon and rectal cancer? (Clinicopathological comparison between colonic and rectal carcinomas) . Oncology . 2007;73:52–57
  83. Kalady MF , Sanchez JA , Manilich E , et al.  Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas . Dis Colon Rectum . 2009;52:1039–1045
  84. Cunningham D , Atkin W , Lenz HJ , et al.  Colorectal cancer . Lancet . 2010;375:1030–1047
  85. Araki K , Furuya Y , Kobayashi M , et al.  Comparison of mucosal microvasculature between the proximal and distal human colon . J Electron Microsc (Tokyo) . 1996;45:202–206
  86. Berlin JA , Longnecker MP , Greenland S . Meta-analysis of epidemiologic dose-response data . Epidemiology . 1993;4:218–228
  87. Hirayama T . A large scale cohort study on the effect of life styles on the risk of cancer by each site. (In Japanese) . Gan No Rinsho . 1990; spec no:233-242
  88. Fira-Mladinescu C , Fira-Mladinescu O , Doroftei S , et al.  [Food intake and colorectal cancers; an ecological study in Romania] . Rev Med Chir Soc Med Nat Iasi . 2008;112:805–811 Romanian
  89. Ngoan le T , Thu NT , Lua NT , et al.  Cooking temperature, heat-generated carcinogens, and the risk of stomach and colorectal cancers . Asian Pac J Cancer Prev . 2009;10:83–86

rectumkanker, darmkanker, omega-3 vetzuren, visolie, vis, endeldarmkanker


Plaats een reactie ...

Reageer op "Regelmatig verse vis eten kan darmkanker en vooral rectumkanker - endeldarmkanker voorkomen"


Gerelateerde artikelen
 

Gerelateerde artikelen

Visolie suppletie vermindert >> Omega-3 vetzuren - visolie >> Visolie vermindert de bijwerkingen >> Visolie aanvullend op chemo >> Visolie zou effectiviteit >> Omega-3 vetzuren en soja / >> Visolie heeft een positief >> Visolie gegeven naast chemo >> Vis eten - 2x per week - verbetert >> Regelmatig verse vis eten >>