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30 augustus 2016: Bron: Chen WT et al; Nutr Res 2014 Jul;34(7):585-94:PMID 25150117

Wanneer patiënten met uitgezaaide darmkanker naast een chemokuur ( FOLFOX = leucovorin, 5-fluorouracil, en oxaliplatin) een voedingssupplement (MP-6) met 6 verschillende voedingsstoffen erbij innemen gedurende 16 weken dan blijkt op 1,5 jaars-meting (77 weken) de progressievrije ziekte (0.0% vs 15.8%, P = .026) en het bijwerkingenprofiel (28.9% vs 2.9%, respectievelijk, P = .004) veel beter te zijn voor de MP-6 groep dan voor de placebogroep.
Ook bleek een statistisch hoger niveau van creatine in het bloed (wat duidt op verslechtering van de ziekte en lichamelijike conditie) in de placebogroep in vergelijking met de MB-6 group (29% vs 5.9%, P = .014).

Het MP-6 voedingssupplement gebruikt in deze studie bestond uit een gefermenteerd soja extract, groene thee extract, Antrodia camphorata mycelia, spirulina, grapefruit extract, en een curcumin extract.

MP-6 voedingssupplement

Foto: Enkele van de voedingstoffen met medicinale werking verwerkt in MP-voedingssupplement

Alle genoemde voedingstoffen zijn in afzonderlijke studies ook wel bewijzen gevonden voor therapeutische effecten, zie onze literatuurlijst - darmkanker, maar na 1,5 jaar (77 weken) nog geen progressie van de ziekte is wel uitzonderlijk te noemen bij deze groep van patiënten met uitgezaaide darmkanker. En dan te bedenken dat patiënten die het voedingssupplement namen na 16 weken zijn gestopt met innemen daarvan. 

In respons en overall overleving zat nog geen verschil maar dat is ook moeilijk aan te tonen in een studie die nog slechts 1,5 jaar duurde. Wordt hopelijk vervolgd met ook verschillen in overall overleving en minder kansen op recidief.

Het volledige studieverslag: Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer. is tegen betaling in te zien.

Hier het originele abstract met referentielijst gerelateerd aan deze studie:

MB-6 is a promising botanical supplement that may increase the effectiveness of chemotherapy in patients with metastatic colorectal cancer.

Nutr Res. 2014 Jul;34(7):585-94. doi: 10.1016/j.nutres.2014.06.010. Epub 2014 Jun 24.

Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer.

Chen WT1, Yang TS2, Chen HC3, Chen HH4, Chiang HC5, Lin TC3, Yeh CH6, Ke TW5, Chen JS2, Hsiao KH7, Kuo ML8.

Author information

Abstract

Natural products, such as fermented soybeans, have been used to treat various physical conditions, including cancer. MB-6 is a botanical preparation composed of fermented soybean extract, green tea extract, Antrodia camphorata mycelia, spirulina, grape seed extract, and curcumin extract. Based on this, we hypothesized that MB-6 would increase the effectiveness of chemotherapy in patients with colon cancer. In a rodent study, MB-6, in combination with leucovorin/5-fluorouracil chemotherapy, increased the survival rate and life span of colon cancer tumor-bearing BALB/c mice as compared with treatment with chemotherapy alone. In a proof-of-concept clinical study, 72 patients with metastatic colorectal cancer were randomized to receive leucovorin, 5-fluorouracil, and oxaliplatin in combination with either MB-6 or placebo for 16 weeks. The primary outcome was the best overall response, and secondary outcomes included progression-free survival, overall survival, and adverse effects. Up to 77 weeks after treatment, there was follow-up with the patients. No significant difference in the best overall response rate and overall survival was observed between the 2 groups. Patients in the MB-6 group had a significantly lower disease progression rate than patients in the placebo group, during the study period (0.0% vs 15.8%, P = .026). The placebo group had a significantly higher incidence of adverse events at least grade 4 compared with the MB-6 group (28.9% vs 2.9%, respectively, P = .004) and a significantly higher occurrence of increased serum creatinine compared with the MB-6 group (29% vs 5.9%, P = .014). MB-6 is a promising botanical supplement that may increase the effectiveness of chemotherapy in patients with metastatic colorectal cancer.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

BALB/c mice; Herbal medicine; MB-6; Metastatic colorectal cancer; Overall survival; Progression-free survival; Tolerability

PMID:
25150117
DOI:
10.1016/j.nutres.2014.06.010
[PubMed - indexed for MEDLINE]

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complementair, voeding, bijwerkingen, progressievrije ziekte, uitgezaaide darmkanker, FOLFOX, voedingssupplement MP 6, gefermenteerd soja extract, groene thee extract, Antrodia camphorata mycelia, spirulina, grape fruit extract, curcumin extract, placebo


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1 Reactie op "Voedingssupplement met 6 voedingstoffen - MP 6 aanvullend op FOLFOX geeft langere progressievrije ziekte en minder ernstige bijwerkingen bij uitgezaaide gevorderde darmkanker."

  • Janneke Brederveld :
    02/04/2017
    Ik zou graag MP-6 willen gebruiken, maar hoe kom ik eraan? Is het ergens te koop?

    Vriendelijke groeten,

    Janneke
    Comment

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