8 november 2018: Lees ook dit verslag van een man met uitgezaaide darmkanker die alnsog geneest d.m.v. immuuntherapie met het RIGVIR virus: 

https://kanker-actueel.nl/man-met-uitgezaaide-darmkanker-stadium-4-kras-pos-geneest-alsnog-met-combinatie-van-immuuntherapie-met-rigvir-virus-plus-folfox-en-bevacizumab-en-is-al-7-jaar-kankervrij.html

8 november 2018: Bron: European Journal of Pharmacology Volume 837, 15 October 2018, Pages 117-126

Immuuntherapie met gemoduleerde oncologische virussen is een snelgroeiend veld binnen de oncologie. Verschillende virussen zijn al vele malen in klinische trials onderzocht en een aantal daarvan zijn ook door FDA en EMU erkend als geregistreerd behandelingsvirus. Een van de eerste virussen, het Rigvir virus is een immuunstimulerend virus met bewezen therapeutische effecten bij o.a. melanomen, , lokale behandeling van huidkanker en onderhuidse uitzaaiingen van melanomen voor de preventie van uitzaaiingen en geregistreerd in o.a. Letland, Georgië, Armenië en Oezbekistaan.

Het doel van deze  overzichtsstudie is om een overzicht te geven van de ontwikkeling van het Rigvir virus en van andere virussen in het algemeen.

Uit de inleiding en abstract vertaald:

De veiligheid van het geselecteerde en aan het melanoom aangepaste ECHO-7-virus Rigvir werd getest bij meer dan 180 patiënten zonder ernstige bijwerkingen. Voordat de registratie een feit werd werden meer dan 700 kankerpatiënten behandeld met het RIGVIR virus: meer dan 540 melanoompatiënten en patiënten met late stadium maagkanker (ca. 90),  darmkanker (ca. 60 patiënten) en andere vormen van kanker met solide tumoren. Patiënten werden gedurende 3 jaar na de operatie met Rigvir behandeld en vergeleken met immunotherapie. 

De mediane 3- en 5-jaars totale overleving bleek beduidend hoger te zijn bij met het Rigvir virus behandelde patiënten. In opeenvolgende retrospectieve studies vertoonden de met Rigvir behandelde patiënten met stadium II-melanoom een 6,67-voudig verlaagd risico op ziekteprogressie in vergelijking met de patiënten die volgens de standaard richtlijnen waren behandeld, en stadium-IB en stadium-II melanoompatiënten die Rigvir-therapie hadden gekregen hadden een  4.39-6.57-voudig lager risico op overlijden. Deze resultaten worden bevestigd en uitgebreid met casestudies. 

Een andere studie:

In this study 44 Rigvir treated stage II melanoma patients were included, and 36 patients that had only been observed according to current international melanoma guidelines. Age and sex was not statistically significantly different between the groups (P > 0.05) (calculated from the data of Doniņa et al. (2012)).

The progression-free survival was analysed by Kaplan-Meier analysis (Fig. 5). The results show that the risk for disease progression (calculated as hazard ratio) was statistically significantly (P < 0.001) decreased 6.67-fold by Rigvir treatment compared to observation (Doniņa et al., 2012).

Fig. 5
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Fig. 5. Kaplan-Meier analysis plot of the effect of Rigvir on progression-free survival in stage II (A,B,C) melanoma patients following surgery. Rigvir N = 44

, Observation N = 36
. Statistical difference between groups: P < 0.001 (from Doniņa et al. (2012), with permission)

Lees ook dit studierapport van drie patienten (melanoom, longkanker en een botsarcoom) die allemaal succesvol hun kanker onder controle kregen met het RIGVIR virus: 

Long‐term treatment with the oncolytic ECHO‐7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient‐three case reports

Uit het studieverslag:

De hier beschreven patiënten werden 3,5, 7,0 en 6,6 jaar geleden gediagnosticeerd en hun toestand is verbeterd en stabiel gebleven gedurende respectievelijk 1,5, 6,5 en 4 jaar. Deze observaties suggereren dat virotherapie met behulp van Rigvir met succes kan worden gebruikt bij langdurige behandeling van patiënten met melanoom stadium IV M1c, kleincellig longkanker stadium IIIA en histiocytisch sarcoom stadium IV en daarom zouden kunnen worden opgenomen in prospectieve klinische onderzoeken.

image
Figure 4
Cytology of biopsy samples of the small cell lung cancer patient. Lymph node small cell cancer cells (purple) and erythrocytes (blue‐green). Light microscopy. Giemsa stain. Scale bar is 100 μm.

Bovenstaande is een verkorte versie van de introductie van deze grote reviewstudie: The advent of oncolytic virotherapy in oncology: The Rigvir® story

en beschrijft niet alleen de effecten van het RIGVIR virus bij melanomen maar bij veel andere verschillende vormen van kanker. Met overal studieverwijzingen enz. 

M.i. geeft deze overzichtsstudie een mooi beeld van de ontwikkeling van het RIGVIR virus maar ook van andere gemoduleerde virussen en wat immuuntherapie met een gemoduleerd virus kan betekenen in een behandeling van kanker.

Hier het abstract van de studie met referentielijst.

Rigvir is a promising immunotherapy medicine for the treatment of melanoma and prevention of metastases as a monotherapy, and potentially also in other cancers as well as in combination therapy.

European Journal of Pharmacology

Volume 837, 15 October 2018, Pages 117-126
European Journal of Pharmacology
Review

The advent of oncolytic virotherapy in oncology: The Rigvir® story

Abstract

Oncolytic viruses are a fast-developing cancer treatment field. Numerous viruses have been tested in clinical trials and three are approved. The first, Rigvir, is an immunomodulator with anti-tumour effect for treatment of melanoma, local treatment of skin and subcutaneous metastases of melanoma, for prevention of relapse and metastasis after radical surgery registered in Latvia, Georgia, Armenia and Uzbekistan. The aim of the present review is to summarize the development of Rigvir. Approximately 60 viruses were screened preclinically. Clinical safety and efficacy trials were with 5 oncolytic enteroviruses. Safety of the selected and melanoma-adapted ECHO-7 virus Rigvir was tested in over 180 patients with no severe adverse events observed. Pre-registration efficacy studies involved over 700 cancer patients: over 540 melanoma patients, and patients with late stage stomach (ca. 90), colorectal cancer (ca. 60), and other cancers. Patients were treated with Rigvir for 3 years after surgery and compared to immunotherapy: 3- and 5-year overall survival appeared to be increased in Rigvir treated patients. In post-marketing retrospective studies, Rigvir-treated stage II melanoma patients showed a 6.67-fold decreased risk for disease progression in comparison to those that had been observed according to guidelines, and stage IB and stage II melanoma patients that had received Rigvir therapy had 4.39–6.57-fold lower mortality. The results are confirmed and extended by case reports. Several immunological markers have been measured. In conclusion, Rigvir is an oncotropic and oncolytic virus for treatment of melanoma; the results will be confirmed and updated by modern clinical studies.

6. Conclusions

The present results suggest that Rigvir is the first oncolytic virotherapy that is approved for treatment of melanoma. It has been used also in several other cancers, for example, gastric and rectal cancer. Rigvir is a genetically non-modified, oncotropic and oncolytic ECHO-7 virus; the side effects are low grade and well tolerated. The first Rigvir marketing authorization was approved in 2004 and Rigvir has been reimbursed in Latvia since the middle of 2011, where over 2/3 of the reimbursed melanoma patients have been treated with Rigvir. Since most of the clinical studies were performed before 1991, the results would benefit from updated, modern safety and efficacy clinical studies. As a part of this, also appropriate biomarkers are being sought to more accurately identify the right target patient population to increase the response rate. Rigvir is a promising immunotherapy medicine for the treatment of melanoma and prevention of metastases as a monotherapy, and potentially also in other cancers as well as in combination therapy.

Conflicts of interest

AT, AR, KB, DV, and PA are employees of the International Virotherapy Center or its affiliates.

References

Abidi et al., 2007
M.H. Abidi, I. Tove, R.B. Ibrahim, D. Maria, E. PeresThalidomide for the treatment of histiocytic sarcoma after hematopoietic stem cell transplant
Am. J. Hematol., 82 (2007), pp. 932-933, 10.1002/ajh.20913
Alberts et al., 2016
P. Alberts, E. Olmane, L. Brokāne, Z. Krastiņa, M. Romanovska, K. Kupčs, S. Isajevs, G. Proboka, R. Erdmanis, J. Nazarovs, D. VenskusLong-term treatment with the oncolytic ECHO-7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient-three case reports
APMIS, 124 (2016), pp. 896-904, 10.1111/apm.12576
Aleksandrova and Garklāva, 1969a
M.A. Aleksandrova, R. GarklāvaDetermination of sensitivity of malignant tumours in laboratory animals to human enteroviruses by immunofluorescence method
T. Stūris, A. Mucenicece, M. Aleksandrova, I. Chernobayeva, A. Volrāte (Eds.), Viral Oncotropism (In Russian), Microbiology Institute of the Latvian Academy of Sciences, Riga (1969), pp. 35-40
Aleksandrova et al., 1969b
M.A. Aleksandrova, R. Garklāva, Z.I. VeselersDetermination of viral spectrum of some human tumors by laboratory methods
T. Stūris, A. Mucenicece, M. Aleksandrova, I. Chernobayeva, A. Volrāte (Eds.), Viral Oncotropism (In Russian), Microbiology Institute of the Latvian Academy of Sciences, Riga (1969), pp. 53-60
Asada, 1974
T. AsadaTreatment of human cancer with mumps virus
Cancer, 36 (1974), pp. 1907-1928, 10.1002/1097-0142(197412)34:6<1907::AID-CNCR2820340609>3.0.CO;2-4
Austin and Boone, 1979
F.C. Austin, C.W. BooneVirus augmentation of the antigenicity of tumor cell extracts
G. Klein, S. Weinhouse (Eds.), Advances in Cancer Research, Academic Press, New York, San Francisco, London (1979), pp. 301-346
Bartlett et al., 2013
D.L. Bartlett, Z. Liu, M. Sathaiah, R. Ravindranathan, Z. Guo, Y. He, Z.S. GuoOncolytic viruses as therapeutic cancer vaccines
Mol. Cancer, 12 (2013), p. 103, 10.1186/1476-4598-12-103
Bergelson et al., 1994
J.M. Bergelson, M. Chan, K.R. Solomon, N.F. St John, H. Lin, R.W. FinbergDecay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses
Proc. Natl. Acad. Sci. USA, 91 (1994), pp. 6245-6248, 10.1073/pnas.91.13.6245
Boldt and Armstrong, 1976
D.H. Boldt, J.P. ArmstrongRosette formation between human lymphocytes and sheep erythrocytes. inhibition of rosette formation by specific glycopeptides
J. Clin. Investig., 57 (1976), pp. 1068-1078, 10.1172/JCI108349
Bommareddy et al., 2017
P.K. Bommareddy, A. Patel, S. Hossain, H.L. KaufmanTalimogene Laherparepvec (T-VEC) and other oncolytic viruses for the treatment of melanoma
Am. J. Clin. Dermatol., 18 (2017), pp. 1-15, 10.1007/s40257-016-0238-9
Brokāne et al.,
Brokāne, L., Jaunalksne, I., Tilgase, A., Kojalo, U., Alberts, P., Unpublished results. Statistical analysis of changes in immunological parameters of oncological patients between day 1 and Day 5 of Rigvir treatment. pp. 1–35.
Brūvere et al., 1980
R. Brūvere, L. Vītoliņa, R. Garklāva, I. Priedīte, A. MucenieceInfluence of a viral immunomodulator (Rigvir®) on cellular composition and topographic characteristics of the infiltration of the stroma of primary tumours of colorectal cancer (In Russian)
Proc. Latv. Acad. Sci., 396 (1980), pp. 137-142
Brūvere et al., 2002a
R. Brūvere, O. Heisele, A. Ferdats, A. Rupais, A. MucenieceEchovirus-mediated biotherapy for malignant tumours: 40 years of investigation
Acta Med. Litu. Suppl., 9 (2002), pp. 97-100
Brūvere et al., 2002b
Brūvere, R., Heisele, O., Ferdats, A., Rupais, A., Muceniece, A., 2002b. Echovirus-mediated biotherapy for malignant tumours: 40 years of investigation. In: Proceedings of the Third Baltic Congress of Oncology, 2–4 May, Vilnius, Lithuania, 251.
Brūvere et al., 2006
Brūvere, R., Feldmane, G., Ferdats, A., Heisele, O., Muceniece, A., 2006. Adjuvant immunotheraphy with virus-mediated biomodulators developed in Latvia: experimental and clinical data. Abstracts of the Perspectives in Melanoma X and The Third Annual International Melanoma Research Congress 14–16 September, Noordwijk, The Netherlands. Melanoma Research 16, S34-ABS-0058.
Carson et al., 2010
J. Carson, D. Haddad, M. Bressman, Y. FongOncolytic herpes simplex virus 1 (HSV-1) vectors: increasing treatment efficacy and range through strategic virus design
Drugs Future, 35 (2010), pp. 183-195, 10.1358/dof.2010.35.3.1470166
Čēma et al., 2001
Čēma, I., Proboka, G., Tārs, J., Skağers, A., Kornevs, E., Muceniece, A., Bīgestāns, A., Lauskis, G., 2001. Melanoma of the facial skin and oral mucosa (In Latvian). In: Proceedings of the 4th Latvian Congress of Physicians, Riga, Latvia, 52.
Cheng et al., 2015
P.-H. Cheng, S.L. Wechman, K.M. McMasters, H.S. ZhouOncolytic replication of E1b-Deleted Adenoviruses
Viruses, 7 (2015), pp. 5767-5779, 10.3390/v7112905
Chernobayeva and Muceniece, 1966
Chernobayeva, I., Muceniece, A., 1966. Pathomorphology of the transplantable human tumour treated with chemotherapeutic agents and viruses. In: Proceedings of Section II-03-c. Ninth International Cancer Congress, 23–29 Oct., Tokyo, Japan., 453.
Cherry, 2004
J.D. CherryEnteroviruses and parechoviruses
R. Feigin, J.D. Cherry, G.J. Demmler, S.L. Kaplan (Eds.), Feigin and Cherry's Textbook of Pediatric Infectious Diseases (5th ed.) (2004), pp. 1984-2041
Cherry and Krogstad, 2014
J.D. Cherry, P. KrogstadEnteroviruses, parechoviruses and saffold viruses
J. Cherry, G.J. Demmler-Harrison, S.L. Kaplan, W.J. Steinbach, P.J. Hotez (Eds.), Feigin and Cherry’s Textbook of Pediatric Infectious Diseases (7th ed.) (2014), pp. 2051-2108
Choi et al., 2016
A.H. Choi, M.P. O’Leary, Y. Fong, N.G. ChenFrom benchtop to bedside: a review of Oncolytic Virotherapy
Biomedicines, 4 (2016), p. 18, 10.3390/biomedicines4030018
Choudhary, 2017
Choudhary, M.C., 2017. Echovirus infection. In: Cunha, B.A. (Ed.), Medscape. Available at: 〈https://emedicine.medscape.com/article/216564-overview#showall〉 (Accessed 4 April 2018).
Clarkson et al., 1995
N.A. Clarkson, R. Kaufman, D.M. Lublin, T. Ward, P.A. Pipkin, P.D. Minor, D.J. Evans, J.W. AlmondCharacterization of the echovirus 7 receptor: domains of CD55 critical for virus binding
J. Virol., 69 (1995), pp. 5497-5501
Conry et al., 2018
R.M. Conry, B. Westbrook, S. McKee, T.G. NorwoodTalimogene laherparepvec: first in class oncolytic virotherapy
Hum. Vaccin. Immunother., 14 (2018), pp. 839-846, 10.1080/21645515.2017.1412896
Curti et al., 2017
B. Curti, J. Richards, S. Hallmeyer, M. Faries, R. Andtbacka, G. Daniels, M. Grose, D.R. ShafrenAbstract CT114: the MITCI (Phase 1b) study: a novel immunotherapy combination of intralesional Coxsackievirus A21 and systemic ipilimumab in advanced melanoma patients with or without previous immune checkpoint therapy treatment
Cancer Res. (2017), p. 77
DePace, 1912
N. DePaceSulla scomparsa di un enorme vegetante del collo dell’utero senza cura chirugica cancro
La Ginecol., 9 (1912), pp. 82-88
Dock, 1904
G. DockThe influence of complicating diseases upon leukaemia
Am. J. Med. Sci., 127 (1904), pp. 563-592
Doniņa et al., 2012
S. Doniņa, O. Holodņuka, I. Strēle, G. ProbokaAvailable pharmaceutical therapies for cutaneous melanoma in Latvia (In Latvian)
Latv. Ārsts (2012), pp. 39-42
Doniņa et al., 2015
S. Doniņa, I. Strēle, G. Proboka, J. Auziņš, P. Alberts, B. Jonsson, D. Venskus, A. MucenieceAdapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in melanoma patients after surgical excision of the tumour in a retrospective study
Melanoma Res., 25 (2015), pp. 421-426, 10.1097/CMR.0000000000000180
〈https://journals.lww.com/melanomaresearch/Fulltext/2015/10000/Adapted_ECHO_7_virus_Rigvir_immunotherapy.7.aspx〉
Duffy et al., 2017
M.R. Duffy, K.D. Fisher, L.W. SeymourMaking Oncolytic virotherapy a clinical reality: the European contribution
Hum. Gene Ther., 28 (2017), pp. 1033-1046, 10.1089/hum.2017.112
Dummer et al., 2015
R. Dummer, A. Hauschild, N. Lindenblatt, G. Pentheroudakis, U. KeilholzCutaneous melanoma: ESMO clinical practice Guidelines for diagnosis, treatment and follow-up
Ann. Oncol., 26 (Suppl. 5) (2015), pp. v126-v132, 10.1093/annonc/mdv297
Dupuytren, 1829
G. DupuytrenDe la gangrène spontanèe générale et partielle des tumeurs cancéreuses du sein
J. Hebdom Med., 4 (1829), pp. 38-41
Edge et al., 2010
S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, A.I. Trotti
American Joint Committee on Cancer (AJCC) Cancer Staging Manual (7th ed.), Springer, New York, NY (2010)
Ferdats et al., 1993
A. Ferdats, A. Volrāte, O. Heisele, L. Glinkina, A. MucenieceInduction of alloimmunity to the melanoma associated antigen by enterovirus ECHO-7
Proc. Latv. Acad. Sci., B550 (1993), pp. 65-67
Ferdats et al., 1999
Ferdats, A., Heisele, O., Brūvere, R., Rupais, A., Desjatnikova, I., Petrovska, R., Muceniece, A., 1999. Adjuvant immunotherapy with Echovirus vaccine for malignant melanoma. In: Proceedings of the Abstract 3rd International Conference.The Adjuvant Therapy of Malignant Melanoma, London, UK, P-17, p. 23.
Fiola et al., 2006
C. Fiola, B. Peeters, P. Fournier, A. Arnold, M. Bucur, V. SchirrmacherTumor selective replication of Newcastle disease virus: association with defects of tumor cells in antiviral defence
Int. J. Cancer, 119 (2006), pp. 328-338, 10.1002/ijc.21821
Foster, 2002
J.R. FosterOne hundred years of virology: a chief's perspective
Commun. Dis. Public Health, 5 (2002), pp. 78-86
Fukuhara et al., 2016
H. Fukuhara, Y. Ino, T. TodoOncolytic virus therapy: a new era of cancer treatment at dawn
Cancer Sci., 107 (2016), pp. 1373-1379, 10.1111/cas.13027
Garbe et al., 2016
C. Garbe, K. Peris, A. Hauschild, P. Saiag, M. Middleton, L. Bastholt, J.J. Grob, J. Malvehy, J. Newton-Bishop, A.J. Stratigos, H. Pehamberger, A.M. EggermontEuropean Dermatology Forum (ED), European Association of Dermato-Oncology (EADO), European Organisation for Research Treatment of Cancer (EORTC), 2016. Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline - Update
Eur. J. Cancer, 63 (2016), pp. 201-217, 10.1016/j.ejca.2016.05.005
Garber, 2006
K. GarberChina APproves World's First Oncolytic Virus therapy for cancer treatment
J. Natl. Cancer Inst., 98 (2006), pp. 298-300, 10.1093/jnci/djj111
Garklāva, 1969
R. GarklāvaThe adsorption of some enteroviruses in tissues of human stomach and breast cancer (In Russian)
T. Stūris, A. Mucenicece, M. Aleksandrova, I. Chernobayeva, A. Volrāte (Eds.), Viral Oncotropism, Microbiology Institute of the Latvian Academy of Sciences, Riga (1969), pp. 41-52
Garklāva and Muceniece, 1966
R. Garklāva, A. MucenieceComparative data on the sensitivity of human angiosarcoma tumour cells to enteroviruses in vivo and in vitro (In Russian)
R. Kukaine, A. Muceniece, L. Nagajeva, T. Stūris, I. Chernobayeva (Eds.), Viruses in Oncology (In Russian), Microbiology Institute of the Latvian Academy of Sciences, Riga (1966), pp. 305-310
Garklāva et al., 1979
R. Garklāva, R. Brūvere, L. Vītoliņa, I. Priedīte, A. MucenieceMorphological and clinical parallels of changing rectal cancer during combined treatment (In Russian)
A. Muceniece (Ed.), Immunological Aspects of Viral Oncotropism, Zinātne, Riga (1979), pp. 114-120
Garklāva et al., 1981
R. Garklāva, I. Priedīte, A. MucenieceLong-term results of surgical treatment of patients with gastric and rectal cancer after immunostimulation with a nonpathogenic enterovirus., immunocompetence and immunotherapy of cancer patients (In Russian)
Kemerovo (1981), pp. 77-91
Gelfand et al., 1963
H.M. Gelfand, A.H. Holguin, G.E. Marchetti, P.M. FeorinoA continuing surveillance of enterovirus infections in healthy children in Six United States cities. I. Viruses isolated during 1960 and 1961
Am. J. Hyg., 78 (1963), pp. 358-375
Glinkina, 1993
Glinkina, L., 1993. Effect of Rigvir® on systemic and local manifestations of immunity in patients with melanoma and gastric cancer (In Russian). Thesis., pp. 1–171.
Glinkina and Brūvere, 1992
L.S. Glinkina, R.Z. BrūvereThe reaction of the T-immunity system in patients with malignant skin melanoma and stomach cancer to active non-specific immunotherapy (In Russian)
Vopr. Onkol., 38 (1992), pp. 659-666
Glinkina et al., 1992a
L.S. Glinkina, R.Z. Brūvere, D.R. Venskus, R.R. Garklāva, A.J. MucenieceCellular immunity indices of patients with malignant melanoma using the viral immunomodulator Rigvir (In Russian)
Vopr. Onkol., 38 (1992), pp. 540-547
Glinkina et al., 1992b
L.S. Glinkina, O.G. Heisele, R.R. Garklāva, A.J. MucenieceHumoral immunity indices of patients with malignant skin melanoma using the viral immunomodulator Rigvir (In Russian)
Vopr. Onkol., 38 (1992), pp. 534-540
Goodfellow et al., 2000
I.G. Goodfellow, R.M. Powell, T. Ward, O.B. Spiller, J.W. Almond, D.J. EvansEchovirus infection of rhabdomyosarcoma cells is inhibited by antiserum to the complement control protein CD59
J. Gen. Virol., 81 (2000), pp. 1393-1401, 10.1099/0022-1317-81-5-1393
Gounder et al., 2015
M. Gounder, V. Desai, D. Kuk, N. Agaram, M. Arcila, B. Durham, M.L. Keohan, M.A. Dickson, S.P. D'Angelo, N. Shukla, C. Moskowitz, A. Noy, R.G. Maki, D.A. Herrera, A. Sanchez, A. Krishnan, A. Pourmoussa, L.X. Qin, W.D. TapImpact of surgery, radiation and systemic therapy on the outcomes of patients with dendritic cell and histiocytic sarcomas
Eur. J. Cancer, 51 (2015), pp. 2413-2422, 10.1016/j.ejca.2015.06.109
Greene et al., 2002
F.L. Greene, D.L. Page, I.D. Fleming, A.G. Fritz, C.M. Balch, D.G. Haller, M. Morrow
American Joint Committee on Cancer (AJCC) Cancer Staging Manual (Part I) (6th ed.), Springer, New York (2002)
Grigalinovičs and Petrovska, 1988
H. Grigalinovičs, R. PetrovskaMorphological changes of human osteosarcoma cells in cell culture caused by viral immunomodulator (Rigvir®) (In Russian)
Proc. Latv. Acad. Sci., 497 (1988), pp. 69-71
Grigalinovičs et al., 1988
H. Grigalinovičs, M. Rudzītis, M. Skudra, B. Popēna, I. Desjatnikova, R. GarklāvaThe effect of viral immunomodulator (Rigvir®) on the morphology and survival of cutaneous melanoma patients (In Russian)
Proc. Latv. Acad. Sci., 497 (1988), pp. 72-75
Grogan et al., 2008
T.M. Grogan, S.A. Pileri, J.K.C. Chan, L.M. Weiss, C.D.M. FletcherHistiocytic sarcoma
S.H., C.E. Swerdlow, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein, J. Thiele, J.W. Vardiman (Eds.), WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (4th ed.), International Agency for Research on Cancer, WHO Press, Geneva, Switzerland (2008), pp. 356-357
Hastie et al., 2016
E. Hastie, M. Cataldi, M.J. Moerdyk-Schauwecker, S.A. Felt, N. Steuerwald, V.Z. GrdzelishviliNovel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Oncotarget, 7 (2016), pp. 61601-61618, 10.18632/oncotarget.11202
He et al., 2002
Y. He, F. Lin, P.R. Chipman, C.M. Bator, T.S. Baker, M. Shoham, R.J. Kuhn, M.E. Medof, M.G. RossmannStructure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex
Proc. Natl. Acad. Sci. USA, 99 (2002), pp. 10325-10329, 10.1073/pnas.152161599
Heisele et al., 2000
O. Heisele, A. Ferdats, L. EngeleMelanoma associated antigens as additional markers of tumor progression
J. Tumor Marker Oncol., 15 (2000), pp. 147-153
Heisele et al., 2001
O. Heisele, A. Ferdats, L. Engele, A. RupaisClinical value of melanoma associated antigens
J. Tumor Marker Oncol. Abstr., A8 (16) (2001)
(106-106)
Hietanen et al., 2018
E. Hietanen, T. Smura, M. Hakanen, J. Chansaenroj, P. Merilahti, J. Nevalainen, S. Pandey, S. Koskinen, L. Tripathi, Y. Poovorawan, J. Pursiheimo, P. SusiGenome sequences of RIGVIR Oncolytic virotherapy Virus and five other Echovirus 7 isolates
Genome Announc. (2018), p. 6, 10.1128/genomeA.00317-18
Hoption Cann et al., 2006
S.A. Hoption Cann, J.P. van Netten, C. van NettenAcute infections as a means of cancer prevention: opposing effects to chronic infections?
Cancer Detect. Prev., 30 (2006), pp. 83-93, 10.1016/j.cdp.2005.11.001
Hoster et al., 1949
H.A. Hoster, R.P. Zanes, E. von HaamStudies in Hodgkin's syndrome IX. The association of “Viral” Hepatitis and Hodgkin's disease (a preliminary report)
Cancer Res., 9 (1949), pp. 473-480
Ismailov et al., 2018
Ismailov, Z., Rasa, A., Bandere, K., Brokāne, L., Tilgase, A., Olmane, E., Nazarovs, J., Alberts, P., 2018. Metastatic Chromophobe Renal Cell Carcinoma (Stage IV) Treatment with the Oncolytic Virus Rigvir® (submitted for publication).
Januškevičs et al., 1988
V.J. Januškevičs, B. Popēna, I. PriedītePostoperative immunostimulation of patients with colorectal cancer (In Russian)
A. Muceniece (Ed.), Modulation of Postoperative Anti-tumor Immunity, Zinātne, Riga (1988), pp. 95-101
Kelly and Russell, 2007
E. Kelly, S.J. RussellHistory of oncolytic viruses: genesis to genetic engineering
Mol. Ther., 15 (2007), pp. 651-659, 10.1038/sj.mt.6300108
Kogon et al., 1969
A. Kogon, I. Spigland, T.E. Frothingham, L. Elveback, C. Williams, C.E. Hall, J.P. FoxThe virus watch program: a continuing surveillance of viral infections in metropolitan New York families. VII. Observations on viral excretion, seroimmunity, intrafamilial spread and illness association in coxsackie and echovirus infections
Am. J. Epidemiol., 89 (1969), pp. 51-61, 10.1093/oxfordjournals.aje.a120915
Kukaine, 1962
R. KukainePoliomyelitis Prophylaxis (In Latvian)
Microbiology Institute of the Latvian Academy of Sciences, Riga (1962)
Lam et al., 2011
H.Y. Lam, S.K. Yeap, M.R. Pirozyan, A.R. Omar, K. Yusoff, S. Abd-Aziz, N.B. AlitheenSafety and clinical usage of Newcastle disease virus in cancer therapy
J. Biomed. Biotechnol., 2011 (2011), p. 718710, 10.1155/2011/718710
Levaditi and Nicolau, 1922
C. Levaditi, S. NicolauSur le culture du virus vaccinal dans les neoplasmes epithelieux
CR Soc. Biol., 86 (1922), p. 928
Lichty et al., 2014
B.D. Lichty, C.J. Breitbach, D.F. Stojdl, J.C. BellGoing viral with cancer immunotherapy
Nat. Rev. Cancer, 14 (2014), pp. 559-567, 10.1038/nrc3770
Limatibul et al., 1978
S. Limatibul, A. Shore, H.M. Dosch, E.W. GelfandTheophylline modulation of E-rosette formation: an indicator of T-cell maturation
Clin. Exp. Immunol., 33 (1978), pp. 503-513
Lin et al., 2018
C.-Z. Lin, G.-L. Xiang, X.-H. Zhu, L.-L. Xiu, J.-X. Sun, X.-Y. ZhangAdvances in the mechanisms of action of cancer-targeting oncolytic viruses
Oncol. Lett., 15 (2018), pp. 4053-4060, 10.3892/ol.2018.7829
Liu et al., 2007
T.C. Liu, E. Galanis, D. KirnClinical trial results with oncolytic virotherapy: a century of promise, a decade of progress
Nat. Clin. Pract. Oncol., 4 (2007), pp. 101-117, 10.1038/ncponc0736
Marsden et al., 2010
J.R. Marsden, J.A. Newton-Bishop, L. Burrows, M. Cook, P.G. Corrie, N.H. Cox, M.E. Gore, P. Lorigan, R. MacKie, P. Nathan, H. Peach, B. Powell, C. WalkerRevised U.K. guidelines for the management of cutaneous melanoma 2010
Br. J. Dermatol., 163 (2010), pp. 238-256, 10.1111/j.1365-2133.2010.09883.x
Moore, 1952
A.E. MooreViruses with oncolytic properties and their adaptation to tumors
Ann. N. Y. Acad. Sci., 54 (1952), pp. 945-952, 10.1111/j.1749-6632.1952.tb39969.x
Muceniece, 1972
A. MucenieceOncotropism of Viruses and the Problem of Virotherapy of Malignant Tumours (In Russian)
Zinātne, Riga (1972)
Muceniece, 1987
Aina MucenieceUnpublished.
Data on file., na (1987), p. na
Muceniece, 1988
A. MucenieceThe sensitivity of melanoma to adapted and non-adapted enteroviruses (In Russian)
A. Muceniece (Ed.), Viruses and Tumour Therapies, Zinātne, Riga (1988), pp. 175-189
Muceniece, 2005
A. MucenieceCancer virotherapy. 1. retrospection and justification (In Latvian)
Doctus Nov. (2005), pp. 40-44
Muceniece and Chernobayeva, 1963
A. Muceniece, I.D. ChernobayevaSome data on the relationship of cancer cells and infectious viruses (In Russian)
R. Kukaine, M. Indulēna, A. Muceniece, T. Veinbergs (Eds.), Problems in Virology, Latvian Academy of Sciences, Riga (1963), pp. 3-11
Muceniece and Ferdats, 1985
Muceniece, A., Ferdats, A., 1985. Virology (In Latvian). pp. 1–200.
Muceniece and Venskus, 2007a
Muceniece, A., Venskus, D., 2007a. How to Assess Immunity - the Melanoma Model. (In Latvian). Riga. p. 122.
Muceniece and Venskus, 2007b
Muceniece, A., Venskus, D., 2007b. How to Assess Immunity - the Melanoma Model. (In Latvian). Riga. pp. 116–117.
Muceniece et al., 1989a
Muceniece, A., Rudzītis, M., Brūvere, R., Desjatnikova, I., Ferdats, A., Garklāva, R., Heisele, O., Popēna, B., Volrāte, A., 1989a. A specially selected and adapted human enterovirus as a biological response modifier with antitumor activity in the treatment of human malignant skin melanoma. In: Proceedings of the Second International Conference on Melanoma, Venice, Italy, Poster Sessions, 16–19 October, 316.
Muceniece et al., 1989b
Muceniece, A., Volrāte, A., Rudzītis, M., Heisele, O., Popēna, B., Garklāva, R., 1989b. Treatment of skin melanoma patients with Rigvir (In Russian). In: Poverennij, A.M., Jershov, F.I., Pelevina, I.I., Neizvestnaja, L.S., Hoptinskaja, S.K. (Eds.), Interferon Inductors and Other Immunomodulators in Radiology and Oncology. A Book of Proceedings (In Russian), Obninsk, pp. 71–74.
Mullen and Tanabe, 2002
J.T. Mullen, K.K. TanabeViral oncolysis
Oncologist, 7 (2002), pp. 106-119, 10.1634/theoncologist.7-2-106
Nalin, 2006
P. NalinWhat causes a fever?
Sci. Am., 294 (2006), p. 104
NCCN, 2018
NCCNNational comprehensive cancer network. Clinical practice guidelines in oncology
Melanoma, 3 (2018), pp. 1-172
〈https://www.nccn.org/professionals/physician_gls/pdf/melanoma.pdf〉
NICE, 2015
NICE, 2015. National Collaborating Centre for Cancer. Melanoma. Assessment and management. NG14, pp. 1–246. 〈https://www.nice.org.uk/guidance/ng14〉.
Ornoy and Tenenbaum, 2006
A. Ornoy, A. TenenbaumPregnancy outcome following infections by coxsackie, echo, measles, mumps, hepatitis, polio and encephalitis viruses
Reprod. Toxicol., 21 (2006), pp. 446-457, 10.1016/j.reprotox.2005.12.007
Ozoliņš, 1995
P. OzoliņšScience in an occupied country
Nature, 378 (1995), p. 533
Pandha et al., 2017
H.S. Pandha, C. Ralph, K. Harrington, B.D. Curti, R.E. Sanborn, W.L. Akerley, S. Gupta, C.M. Rudin, J.E. Rosenberg, D.R. Kaufman, E.V. Schmidt, M. Grose, D. ShafrenKeynote-200 phase 1b: a novel combination study of intravenously delivered coxsackievirus A21 and pembrolizumab in advanced cancer patients
J. Clin. Oncol., 35 (2017), 10.1200/JCO.2017.35.15_suppl.TPS3108
(TPS3108-TPS3108)
Parato et al., 2012
K.A. Parato, C.J. Breitbach, B.F. Le, J. Wang, C. Storbeck, C. Ilkow, J.S. Diallo, T. Falls, J. Burns, V. Garcia, F. Kanji, L. Evgin, K. Hu, F. Paradis, S. Knowles, T.H. Hwang, B.C. Vanderhyden, R. Auer, D.H. Kirn, J.C. BellThe oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers
Mol. Ther., 20 (2012), pp. 749-758, 10.1038/mt.2011.276
Plevka et al., 2010
P. Plevka, S. Hafenstein, K.G. Harris, J.O. Cifuente, Y. Zhang, V.D. Bowman, P.R. Chipman, C.M. Bator, F. Lin, M.E. Medof, M.G. RossmannInteraction of decay-accelerating factor with echovirus 7
J. Virol., 84 (2010), pp. 12665-12674, 10.1128/JVI.00837-10
Pol et al., 2016
J. Pol, A. Buque, F. Aranda, N. Bloy, I. Cremer, A. Eggermont, P. Erbs, J. Fucikova, J. Galon, J.M. Limacher, X. Preville, C. Sautes-Fridman, R. Spisek, L. Zitvogel, G. Kroemer, L. GalluzziTrial Watch-Oncolytic viruses and cancer therapy
Oncoimmunology, 5 (2016), p. e1117740
〈https://doi.org10.1080/2162402X.2015.1117740〉
Power and Bell, 2007
A.T. Power, J.C. BellCell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer
Mol. Ther., 15 (2007), pp. 660-665, 10.1038/sj.mt.6300098
Priedīte et al., 1971
Priedīte, I., Garklāva, R., Brūvere, R., Vītoliņa, L., Muceniece, A., 1971. Results from treatment of rectal cancer (In Russian). In: Proceedings of the III Conference of Estonian, Lithuanian and Latvian oncologists, Riga, Latvia, p. 325.
Proboka et al., 2018
G. Proboka, A. Tilgase, S. Isajevs, A. Rasa, P. AlbertsMelanoma unknown primary brain metastasis treatment with ECHO-7 Oncolytic Virus Rigvir: a case report
Front. Oncol., 8 (2018), p. 43, 10.3389/fonc.2018.00043
Ribas et al., 2017
A. Ribas, R. Dummer, I. Puzanov, A. VanderWalde, R.H.I. Andtbacka, O. Michielin, A.J. Olszanski, J. Malvehy, J. Cebon, E. Fernandez, J.M. Kirkwood, T.F. Gajewski, L. Chen, K.S. Gorski, A.A. Anderson, S.J. Diede, M.E. Lassman, J. Gansert, F.S. Hodi, G.V. LongOncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy
Cell, 170 (2017), pp. 1109-1119, 10.1016/j.cell.2017.08.027
(e1110)
Romero, 2007
J.R. RomeroEnteroviruses and parechoviruses
P.R. Murray (Ed.), Manual of Clinical Microbiology (9th ed.), ASM Press, Washington D.C (2007), pp. 1392-1404
Romero and Modlin, 2015
J.R. Romero, J.F. ModlinCoxsackieviruses, Echoviruses, and numbered Enteroviruses
J.E. Bennett, R. Dolin, M.J. Blaser (Eds.), Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (8th ed.), Elsevier Saunders, Philadelphia (2015), pp. 2080-2090
Rossmann et al., 2002
M.G. Rossmann, Y. He, R.J. KuhnPicornavirus-receptor interactions
Trends Microbiol., 10 (2002), pp. 324-331, 10.1016/S0966-842X(02)02383-1
Rudzītis et al., 1988
Rudzītis, M., Garklāva, R., Popēna, B., Desjatnikova, I., 1988. Increased five-year survival of skin melanoma patients undergoing surgical treatment followed by immunomodulator treatment (In Russian). In: Proceedings of All-Union Symposium Current issues of immunotherapy of tumours, Jūrmala, Latvia 19–21 April, 2, pp. 19–20.
Russell and Peng, 2018
L. Russell, K.W. PengThe emerging role of oncolytic virus therapy against cancer
Chin. Clin. Oncol., 7 (2018), p. 16, 10.21037/cco.2018.04.04
Russell and Peng, 2017
S.J. Russell, K.W. PengOncolytic virotherapy: a contest between apples and oranges
Mol. Ther., 25 (2017), pp. 1107-1116, 10.1016/j.ymthe.2017.03.026
Russell et al., 2012
S.J. Russell, K.W. Peng, J.C. BellOncolytic virotherapy
Nat. Biotechnol., 30 (2012), pp. 658-670, 10.1038/nbt.2287
Sabin, 1981
A.B. SabinParalytic poliomyelitis: old dogmas and new perspectives
Rev. Infect. Dis., 3 (1981), pp. 543-564, 10.1093/clinids/3.3.543
Salk and Salk, 1977
J. Salk, D. SalkControl of influenza and poliomyelitis with killed virus vaccines
Science, 195 (1977), pp. 834-847, 10.1126/science.320661
Sandru et al., 2014
A. Sandru, S. Voinea, E. Panaitescu, A. BlidaruSurvival rates of patients with metastatic malignant melanoma
J. Med. Life, 7 (2014), pp. 572-576
Schreiber et al., 2011
R.D. Schreiber, L.J. Old, M.J. SmythCancer immunoediting: integrating immunity's roles in cancer suppression and promotion
Science, 331 (2011), pp. 1565-1570, 10.1126/science.1203486
Schwartz, 2018
Schwartz, R.A., 2018. Enteroviruses. In: Bronze, M.S. (Ed.), Medscape. Available at: 〈https://emedicine.medscape.com/article/217146-overview#showall〉 (Accessed 4 April 2018).
Shore et al., 1978
A. Shore, H. Dosch, E.W. GelfandInduction and separation of antigen-dependent T helper and T suppressor cells in man
Nature, 274 (1978), pp. 586-587, 10.1038/274586a0
Shores, 2016
T. ShoresUnderstanding Viruses
Jones & Bartlett Publishers, Burlington, Massachusetts (2016)
Southam, 1960
C.M. SouthamDivision of microbiology: present status of oncolytic virus studies
Trans. N. Y. Acad. Sci., 22 (1960), pp. 657-673, 10.1111/j.2164-0947.1960.tb00739.x
Southam and Moore, 1952
C.M. Southam, A.E. MooreClinical studies of viruses as antineoplastic agents, with particular reference to Egypt 101 virus
Cancer, 5 (1952), pp. 1025-1034, 10.1002/1097-0142(195209)5:5<1025::AID-CNCR2820050518>3.0.CO;2-Q
Spiller et al., 2000
O.B. Spiller, I.G. Goodfellow, D.J. Evans, J.W. Almond, B.P. MorganEchoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF
J. Infect. Dis., 181 (2000), pp. 340-343, 10.1086/315210
ta-Scan-Fact-sheet, 2017
ta-Scan-Fact-sheet, 2017. Oncolytic virus therapies in clinical trials, pp. 1–2. 〈https://s20687.pcdn.co/wp-content/uploads/2017/08/ta-Scan-Fact-sheet-6-Oncolytic-Virus-Therapies-in-Clinical-Trials-us-letter-web-1.pdf〉 (Accessed 28 Apr.2018).
Tayeb et al., 2015
S. Tayeb, Z. Zakay-Rones, A. PanetTherapeutic potential of oncolytic Newcastle disease virus: a critical review
Oncolytic Virother., 4 (2015), pp. 49-62, 10.2147/OV.S78600
Tilgase et al.,
Tilgase, A., Proboka, G., Kojalo, U., Alberts, P., Unpublished results. Retrospective statistical analysis of immunological parameters of melanoma patients during and after Rigvir treatment. pp. 1–71.
Tilgase et al., 2018
A. Tilgase, E. Olmane, J. Nazarovs, L. Brokāne, R. Erdmanis, A. Rasa, P. AlbertsMultimodality Treatment of A Colorectal Cancer Stage IV Patient with FOLFOX-4, Bevacizumab, Rigvir Oncolytic Virus and Surgery
Case Rep Gastroenterol, 12 (2018), pp. 457-465
Tilgase et al., 2018b
A. Tilgase, L. Patetko, I. Blāķe, A. Ramata-Stunda, M. Borodušķis, P. AlbertsEffect of the oncolytic ECHO-7 virus Rigvir® on the viability of cell lines of human origin in vitro
J. Cancer, 9 (2018), pp. 1033-1049, 10.7150/jca.23242
Volrāte, 1960
A. VolrāteEnterovirus presence in healthy children (In Latvian)
Proc. Latv. Acad. Sci. (1960), pp. 155-158
Volrāte, 1962
Volrāte, A., 1962. Distribution of Enteroviruses among Healthy Children during Vaccination with Live Poliomyelitis Vaccine. (In Russian). Riga, Latvia. Thesis, pp. 1–267.
Ward et al., 1994
T. Ward, P.A. Pipkin, N.A. Clarkson, D.M. Stone, P.D. Minor, J.W. AlmondDecay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method
EMBO J., 13 (1994), pp. 5070-5074, 10.1002/j.1460-2075.1994.tb06836.x
Ward et al., 1998
T. Ward, R.M. Powell, P.A. Pipkin, D.J. Evans, P.D. Minor, J.W. AlmondRole for beta2-microglobulin in echovirus infection of rhabdomyosarcoma cells
J. Virol., 72 (1998), pp. 5360-5365
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Rigvir virus, immuuntherapie, overzichtsstudie, overall overleving, complete remissies, gemoduleerd virus


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