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26 oktober 2014: Bron: J. Nutr. vol. 136 no. 3 821S-826S

Een knoflook extract met een dosis van 2.4 mL/d vermindert duidelijk het aantal aanwezige poliepen en de omvang ervan in vergelijking met een knoflookextract met een lage dosis, 0.16 mL/d.

Dit blijkt uit een gerandomiseerde studie bij totaal 51 patiënten met aangetoonde darmpoliepen.

knoflook bij darmpoliepen grafiek

Epidemiologische en dierstudies suggereren dat oude knoflook extract (AGE) en zijn organische substituten / vervangers zoals S-allylcysteine en S-allylmercaptocysteine anti-kanker effecten hebben. Knoflook lijkt dus invloed te hebben op het ontstaan van kanker of de groei van tumoren. Interessant is dat knoflook in feite een  middel zou kunnen zijn voor een bepaalde pathway van kanker, want een middel dat zowel darmpoliepen laat verdwijnen c.q. de poliepen in omvang kleiner maakt grijpt in in een proces van ontstaan van kanker, want polipen zijn vaak een voorbode van ontstaan van darmkanker.

Japanse onderzoekers hebben op basis van eerdere gegevens een gerandomiseerde studie opgezet waarbij er twee doses van het knoflookextract werden gebruikt om te kijken of de dosis van het knoflook extract ook een verschillende invloed zou hebben.

Studieresultaten:

Totaal 51 mensen met aantoonbare darmpoliepen werden gerandomiseerd ingedeeld in twee groepen. In eerste instantie werden alle poliepen groter dan 5 mm. operatief verwijderd bij alle deelnemende mensen, daarna kregen zij een knoflook extract. Of een lage dosis, 0.16 mL/d. of een hoge dosis, 2.4 mL/d. 37 mensen voltooiden uiteindelijk de studie. 19 in de behandelgroep (hoge dosis) , 18 in de controlegroep (lage dosis)

Op 6 maanden en 12 maanden werden de omvang en de aantallen van poliepen vastgesteld. In de knoflook lage dosis groep bleek de groei enz. na 12 maanden gelijk in beide groepen. maar in de knoflook hoge dosis groep verminderde het aantal poliepen en ook de omvang van de poliepen die nog niet verdwenen significant, (P = 0.04).

Het volledige studierapport: Aged Garlic Extract Has Potential Suppressive Effect on Colorectal Adenomas in Human is gratis in te zien met grafieken en ook referenties van andere studies met knoflook enz.

Hier het abstract van de studie:

The results suggest AGE (Aged Carlic Extract) suppresses progression of colorectal adenomas in humans. It appears that AGE (Aged Garlic Extract) has multiple pathways to reduce cancer incidence and suppress its growth and proliferation

Aged Garlic Extract Has Potential Suppressive Effect on Colorectal Adenomas in Humans1

  1. Kazuaki Chayama**

+ Author Affiliations

  1. *Department of Endoscopy, Hiroshima University Hospital, Minami-ku, Hiroshima 734–8551, Japan, †Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki 701–0192, Japan, **Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Hiroshima 734–8551, Japan, ‡Health Service Center, Hiroshima University, Higashihiroshima 739–8521, Japan, ††Onomichi General Hospital, Onomichi 722–8508, Japan, ‡‡Wakunaga Pharmaceutical Co., Ltd., Akitakata 739–1195, Japan, and #Wakunaga of America Co., Ltd., Mission Viejo, CA 92691
  1. ↵3To whom correspondence should be addressed. E-mail: colon@hiroshima-u.ac.jp.
 
Next Section

Abstract

Epidemiological and animal studies suggest AGE and its organosulfur constituents, such as S-allylcysteine and S-allylmercaptocysteine have anticarcinogenic effects. To confirm these effects in humans, a preliminary double-blind, randomized clinical trial using high-dose AGE (AGE 2.4 mL/d) as an active treatment and low-dose AGE (AGE 0.16 mL/d) as a control was performed on patients with colorectal adenomas—precancerous lesions of the large bowel. The study enrolled 51 patients who were diagnosed as carrying colorectal adenomas. The patients were randomly assigned to the two groups after adenomas larger than 5 mm in diameter were removed by polypectomy. The number and size of adenomas right before intake (0 mo) and at 6 and 12 mo after intake were measured using colonoscopy. Thirty-seven patients (19 in the active group, 18 in the control group) completed the study and were evaluated for the efficacy of AGE. The number of adenomas increased linearly in the control group from the beginning (the baseline), but AGE significantly suppressed both the size and number of colon adenomas in patients after 12 mo of high-dose treatment (P = 0.04). The results suggest AGE suppresses progression of colorectal adenomas in humans. It appears that AGE has multiple pathways to reduce cancer incidence and suppress its growth and proliferation.

knoflook bij darmpoliepen grafiek

LITERATURE CITED

  1. 1.↵
    Caragay AB. Cancer-preventive foods and ingredients. Food Technol. 1992;46:65–8.
  2. 2.↵
    Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S, Biserni R, Cipriani F, Cocco P, et al. A case-control study of gastric cancer and diet in Italy. Int J Cancer. 1989;44:611–6.
    Medline
  3. 3.↵
    You W, Blot WJ, Chang Y, Ershow A, Yang ZT, An Q, Henderson BE, Fraumeni JF, Wang T. Allium vegetables and reduced risk of stomach cancer. J Natl Cancer Inst. 1989;81:162–4.
    Abstract/FREE Full Text
  4. 4.↵
    Steinmetz KA, Kushi LH, Bostick RM, Folsom AR, Potter JD. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Am J Epidemiol. 1994;139:1–15.
    Abstract/FREE Full Text
  5. 5.↵
    Fleischauer AT, Arab L. Garlic and cancer: a critical review of the epidemiologic literature. J Nutr. 2001;131:1032S–40S.
    Abstract/FREE Full Text
  6. 6.↵
    Amagase H, Petesch B, Matsuura H, Kasuga S, Itakura Y. Intake of garlic and its bioactive components. J Nutr. 2001;131:955S–62S.
    Abstract/FREE Full Text
  7. 7.↵
    United States Pharmacopeia-National Formulary (USP25 NF20). Garlic Fluidextract, 2002. Rockville, Maryland: United States Pharmacopeial Convention; 2002. p. 2553.
  8. 8.↵
    Niihara Y, Borek C, Amagase H. A double blind, randomized, placebo-controlled study of the safety of using aged garlic extract (Kyolic) for patients on oral anticoagulation (coumadin) therapy. FASEB J. 2004;18:A911.
  9. 9.
    Rozenfeld V, Sisca T, Callahan A, Crain J. Double-blind, randomized, placebo-controlled trial of aged garlic extract in patients stabilized on warfarin therapy. Proceedings of the American Society of Health-System Pharmacists; 2000 Dec 3–7; Las Vegas, Nevada.
  10. 10.
    Rozenfeld V, Sisca T, Crain J, Callahan K. Double-blind, randomized, placebo controlled trial of garlic in patients stabilized on warfarin therapy. Proceedings of the 18th Annual Eastern States Conference for Pharmacy Residents and Preceptors; 1999 Apr 21–24; Baltimore, Maryland.
  11. 11.↵
    Budoff MJ, Takasu J, Flores FR, Niihara Y, Lu B, Lau BH, Rosen RT, Amagase H. Inhibiting progression of coronary calcification using aged garlic extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004;39:985–91.
    CrossRefMedline
  12. 12.↵
    Nishino H, Iwashima A, Itakura Y, Matsuura H, Fuwa T. Antitumor-promoting activity of garlic extracts. Oncology. 1989;46:277–80.
    Medline
  13. 13.↵
    Sumiyoshi H, Wargovich MJ. Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds. Cancer Res. 1990;50:5084–7.
    Abstract/FREE Full Text
  14. 14.↵
    Liu J, Lin RI, Milner JA. Inhibition of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and DNA adducts by garlic powder. Carcinogenesis. 1992;13:1847–51.
    Abstract/FREE Full Text
  15. 15.↵
    Kyo E, Uda N, Suzuki A, Kakimoto M, Ushijima M, Kasuga S, Itakura Y. Immunomodulation and antitumor activities of aged garlic extract. Phytomedicine. 1998;5:259–67.
    Medline
  16. 16.↵
    Alberts DS, Martinez ME, Roe DJ, Guillen-Rodriguez JM, Marshall JR, van Leeuwen JB, Reid ME, Ritenbaugh C, Vargas PA, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. N Engl J Med. 2000;342:1156–62.
    CrossRefMedline
  17. 17.↵
    Schatzkin A, Lanza E, Corel D, Lance P, Iber, Caan B, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. N Engl J Med. 2002;342:1149–1155.
  18. 18.↵
    Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med. 1999;340:101–7.
    CrossRefMedline
  19. 19.↵
    Greenberg ER, Baron JA, Tosteston TD, Freeman DH, Beck GJ, Bond JH, Colacchio TA, Coller JA, Frankl HD, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med. 1994;331:141–7.
    CrossRefMedline
  20. 20.↵
    Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R, Petrelli N, Pipas JM, Karp DD, et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med. 2003;348:883–90.
    CrossRefMedline
  21. 21.↵
    Giardiello FM, Hamilton SR, Krush AJ, Piantadosi S, Hylind LM, Celano P, Booker SV, Robinson CR, Offerhaus GJ. Treatment of colonic and rectal adenomas with sulinac in familial adenomatous polyposis. N Engl J Med. 1993;328:1313–6.
    CrossRefMedline
  22. 22.↵
    Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 2000;342:1946–52.
    CrossRefMedline
  23. 23.↵
    Tanaka S, Haruma K, Kunihiro M, Nagata S, Kitadai Y, Manabe N, Sumii M, Yoshihara M, Kajiyama G, et al. Effects of aged garlic (AGE) on colorectal adenomas: a double-blinded study. Hiroshima J Med Sci. 2004;53:39–45.
    Medline
  24. 24.↵
    Amagase H, Milner J. Impact of various sources of garlic and their constituents on 7,12-dimethylbenz[a]anthracene binding to mammary cell DNA. Carcinogenesis. 1993;14:1627–31.
    Abstract/FREE Full Text
  25. 25.↵
    Wargovich MJ. Diallyl sulfide, a flavor component of garlic (Allium sativum) inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis. 1987;8:487–9.
    Abstract/FREE Full Text
  26. 26.↵
    Sumiyoshi H, Wargovich MJ. Effect of Organosulfur compounds on 1,2-dimethyl-hydrazine-induced nuclear toxicity and GST activity in mouse colon. Proc Am Assoc Cancer Res. 1989;30:181.
  27. 27.↵
    Hatono S, Jimenez A, Wargovich MJ. Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase. Carcinogenesis. 1996;17:1041–4.
    Abstract/FREE Full Text
  28. 28.↵
    Hatono S, Wargovich MJ. Role of garlic in disease prevention—preclinical models. In: Lachance PP, editor. Nutraceuticals: Designer Foods III Garlic, Soy and Licorice. Connecticut: Food & Nutrition Press; 1997. p. 139–151.
  29. 29.↵
    Uda N, McKee K, Velasco MA, Montoya RG, Woods C, Wargovich MJ. Chemoprotective effects of aged garlic extract on the phase of colon carcinogenesis. Proc Am Assoc Cancer Res. 1996;37:274.
  30. 30.↵
    Gudi VA, Singh SV. Effect of diallyl sulfide, a naturally occurring anti-carcinogen, on glutathione-dependent detoxification enzymes of female CD-1 mouse tissues. Biochem Pharmacol. 1991;42:1261–5.
    CrossRefMedline
  31. 31.↵
    Dion ME, Milner JA. Garlic inhibits cytochrome P450 2E1 mediated chlorzoxazone metabolism. FASEB J. 1997;11:A370.
  32. 32.↵
    Milner JA, Schaffer EM, Dion M. Anticarcinogenic effects of garlic and associated constituents on chemically induced carcinogenesis. Proceedings of the 2nd International Congress on Phytomedicine; 1996 Sep 11–14; Munich, Germany. p. S-110.
  33. 33.↵
    Sigounas G, Hooker J, Anagnostou A, Steiner M. S-allylmercaptocysteine, a stable thioallyl compound, induces apoptosis in erythroleukemia cell lines. Nutr Cancer. 1997;28:153–9.
    Medline
  34. 34.↵
    Pinto JT, Qiao C, Xing J, Rivlin RS, Protomastro ML, Weissler ML, Tao Y, Thaler H, Heston WD, et al. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture. Am J Clin Nutr. 1997;66:398–405.
    Abstract/FREE Full Text
  35. 35.↵
    Hageman GJ, van Herwijnen MH, Schilderman PA, Rhijnsburger EH, Moonen EJ, Kleinjans JC. Reducing effects of garlic constituents on DNA adduct formation in human lymphocytes in vitro. Nutr Cancer. 1997;27:177–85.
    Medline
  36. 36.↵
    Schaffer EM, Liu JZ, Milner JA. Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. Nutr Cancer. 1997;27:162–8.
    CrossRefMedline
  37. 37.↵
    Weisberger AS, Pensky J. Tumor-inhibiting effects derived from an active principle of garlic (Allium sativum). Science. 1957;126:1112–4.
    FREE Full Text
  38. 38.↵
    Kyo E, Uda N, Kasuga S, Itakura Y. Immunomodulatory effects of aged garlic extract. Proceedings of the Recent Advances on the Nutritional Benefits Accompanying the Use of Garlic as a Supplement. The Pennsylvania State University and the National Cancer Institute; 1998 Nov 15–17; Newport Beach, California.
  39. 39.↵
    Riggs DR, DeHaven JI, Lamm DL. Allium sativum (garlic) treatment for murine transitional cell carcinoma. Cancer. 1997;79:1987–94.
    CrossRefMedline
  40. 40.↵
    Riggs DR, Lamm DL, Campbell PF, Dehaven JL. Antitumor effects of orally administered aged garlic extract in the MBT2 murine bladder cancer model. J Urol. 1995;153:1029.
  41. 41.↵
    Lau BH, Yamasaki T, Gridley DS. Garlic compounds modulate macrophage and T-lymphocyte functions. Mol Biother. 1991;3:103–7.
    CrossRefMedline
  42. 42.↵
    Hirao Y, Sumioka I, Nakagami S, Yamamoto M, Hatono S, Yoshida S, Fuwa T, Nakagawa S. Activation of immunoresponder cells by the protein fraction from aged garlic extract. Phytother Res. 1987;1:161–4.
  43. 43.↵
    Morioka N, Sze LL, Morton DL, Irie RF. A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A. Cancer Immunol Immunother. 1993;37:316–22.
    CrossRefMedline
  44. 44.↵
    Dion ME, Milner JA. Formation and bioactivation of nitrosomorpholine is inhibited by S-allyl cysteine. FASEB J. 1996;10:A498.
  45. 45.↵
    Tsai SJ, Jenq SN, Lee H. Naturally occurring diallyl disulfide inhibits the formation of carcinogenic heterocyclic aromatic amines in boiled pork juice. Mutagenesis. 1996;11:235–40.
    Abstract/FREE Full Text
  46. 46.↵
    Yamasaki T, Teel RW, Lau BHS. Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1. Cancer Lett. 1991;59:89–94.
    Medline
  47. 47.↵
    Nishino H, Nishino A, Takayasu J, Iwashima A, Itakura Y, Kodera Y, Matsuura H, Fuwa T. Antitumor-promoting activity of allixin, a stress compound produced by garlic. Cancer J. 1990;3:20–1.
  48. 48.↵
    Das T, Roychoudhury A, Sharma A, Talukder G. Modification of clastogenicity of three known clastogens by garlic extract in mice in vivo. Environ Mol Mutagen. 1993;21:383–8.
    Medline
  49. 49.
    Lau BH, Woolley JL, Marsh CL, Barker GR, Koobs DH, Torrey RR. Superiority of intralesional immunotherapy with Corynebacterium parvum and Allium sativum in control of murine transitional cell carcinoma. J Urol. 1986;136:701–5.
    Medline
  50. 50.
    Lau BHS, Barker GR, Marsh CL. Intralesional immunotherapy of murine bladder tumor. Proceedings of the 85th Annual Meeting of the American Society for Microbiology; 1985 Mar 3–7; Las Vegas, Nevada. E-95.
  51. 51.
    Marsh CL, Torrey RR, Woolley JL, Barker GR, Lau BHS. Superiority of intralesional immunotherapy with Cornebacterium pravum and Allium sativum in control of murine bladder cancer. J Urol. 1987;137:359–62.
    Medline
  52. 52.
    Lamm DL, Riggs DR, Dehaven JL. Intralesional immunotherapy of murine transitional cell carcinoma using garlic extract. Proceedings of the 1st World Congress on the Health Significance of Garlic and Garlic Constituents; 1990 Aug 28–30; Washington, D.C. p. 30.
  53. 53.
    Tiwari RK, Pinto J, Lin RIS, Qiao CH, Guo L, Ito K, Osborne MP. Biochemical effects of garlic components in human breast epithelial cells. Breast Cancer Res Treat. 1993;27:80.
  54. 54.
    Li G, Qiao CH, Lin RI, Pinto J, Osborne MP, Tiwari RK. Anti-proliferative effects of garlic consitituents in cultured human breast cancer cells. Oncol Rep. 1995;2:787–91.
    Medline
  55. 55.
    Sigounas G, Hooker J, Anagnostou A, Steiner M. S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. Nutr Cancer. 1997;27:186–91.
    Medline
  56. 56.
    Milner JA, Liu JZ. Prevention of 7,12-dimethylbenz[a]anthracene induced mammary tumors by dietary garlic powder supplementation. Proceedings of the 1st World Congress on the Health Significance of Garlic and Garlic Constituents. 1990 Aug 28–30; Washington D.C. p. 25.
  57. 57.
    Zoumas C, Amagase H, Milner J. Impact of dietary lipid, protein and methionine on the ability of garlic to decrease binding of 7,12-dimethylbenz[a]anthracene to mammary DNA. FASEB J. 1992;6:A1392.
  58. 58.
    Schaffer EM, Milner JA. Garlic powder supplementation inhibits the enhancement of dietary fatty acids of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. Proceedings of the16th International Congress of Nutrition. 1997 Jul 27–Aug 1; IUNS; 1997. p. 67.
  59. 59.
    Amagase H, Milner J. Impact of dietary garlic sources on 7,12-dimethylbenz[a]anthracene binding to DNA. FASEB J. 1992;6:A1493.
  60. 60.
    Liu J, Milner J. Influence of dietary garlic powder with and without selenium supplementation on mammary carcinogen adducts. FASEB J. 1990;4:A1117.
  61. 61.
    Schaffer EM, Liu JZ, Milner JA. Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. Nutr Cancer. 1997;27:162–8.
    CrossRefMedline
  62. 62.
    Amagase H, Schaffer EM, Milner JA. Dietary components modify the ability of garlic to suppress 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. J Nutr. 1996;126:817–24.
    Abstract/FREE Full Text
  63. 63.
    Liu JZ, Lin XY, Milner JA. Dietary garlic powder increases glutathione content and glutathione S-transferase activity in rat liver and mammary tissues. FASEB J. 1992;6:A1493.
  64. 64.
    Lin XY, Liu JZ, Milner J. Dietary garlic suppresses DNA-adducts caused by N-nitroso compounds. Carcinogenesis. 1994;15:349–52.
    Abstract/FREE Full Text
  65. 65.
    Lin XY, Liu JZ, Milner JA. Dietary garlic powder suppresses the in vivo formation of DNA adducts induced by N-nitroso compounds in liver and mammary. FASEB J. 1992;6:A1392.
  66. 66.
    Liu JZ, Schaffer EM, Pegg AE, Milner JA. Dietary garlic inhibits mammary carcinogenesis induced by N-methylnitrosourea. FASEB J. 1995;9:A991.
  67. 67.
    Sundaram SG, Milner JA. Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett. 1993;74:85–9.
    CrossRefMedline
  68. 68.
    Sundaram SG, Milner JA. Antitumor effects of organosulfur compounds in garlic against canine mammary tumor cells. FASEB J. 1992;6:2639.
    Abstract
  69. 69.
    Sundaram S, Milner JA. Diallyl disulfide suppresses the growth of human colon tumor cell xenografts in athymic nude mice. J Nutr. 1996;126:1355–61.
    Abstract/FREE Full Text
  70. 70.
    Knowles L, Milner J. Garlic constituents alter cell cycle progression and proliferation. FASEB J. 1997;11:A1391.
  71. 71.
    Sigounas G, Hooker J, Anagnostou A, Steiner M. S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. Nutr Cancer. 1997;27:186–91.
    Medline
  72. 72.
    Wargovich MJ, Woods C, Eng VWS, Stephens LC, Gray K. Chemoprevention of N-nitrosomethyl-benzylamine-induced esphageal cancer in rats by the naturally occurring thioester, diallyl sulfide. Cancer Res. 1988;48:6872–5.
    Abstract/FREE Full Text
  73. 73.
    Tadi PP, Teel RW, Lau BH. Anticandidal and anticarcinogenic potentials of garlic. Int Clin Nutr Rev. 1990;10:423–9.
  74. 74.
    Tadi PP, Teel RW, Lau BHS. Organosulfur compounds of garlic modulate mutagenesis, metabolism, and DNA-binding of aflatoxin B1. Nutr Cancer. 1991;15:87–95.
    Medline
  75. 75.
    Sparnins VL, Mott AW, Barany G, Wattenberg LW. Effects of allyl methyl trisulfide on glutathione S-transferase activity in bp-induced neoplasia in the mouse. Nutr Cancer. 1986;8:211–5.
    Medline
  76. 76.
    Sparnins VL, Barany G, Wattenberg VW. Effects of organosulfur compounds from garlic and onions on benzo-[a]-pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis. 1988;9:131–4.
    Abstract/FREE Full Text
  77. 77.
    Wattenberg LW, Sparnins VL, Barany G. Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. Cancer Res. 1989;49:2689–92.
    Abstract/FREE Full Text
  78. 78.
    Hoon DSB, Sze L, Lin RI, Irie RF. Modulation of cancer antigens and growth of human melanoma by aged garlic extract. Proceedings of the 1st World Congress on the Health Significance of Garlic and Garlic Constituents; 1990 Aug 28–30; Washington, D.C. p. 26.
  79. 79.
    Takeyama H, Hoon DSB, Saxton RE. Morton Dl, Irie RF. Growth inhibition and modulation of cell markers of melanoma by S-allyl cysteine. Oncology. 1993;50:63–9.
    CrossRefMedline
  80. 80.
    Welch C, Wuarin L, Sidell N. Antiproliferative effect of the garlic compound S-allyl cysteine on human neuroblastoma cells in vitro. Cancer Lett. 1992;63:211–9.
    CrossRefMedline
  81. 81.
    Pinto JT, Qiao C, Xing J, Suffoletto B, Rivlin RS, Heston W. Garlic constituents modify expression of biomarkers for human prostatic carcinoma cells. FASEB J. 1997;11:A439.
  82. 82.
    Pinto J, Rivlin R. Garlic and prevention of prostate cancer. In: Lachance PP, editor. Nutraceuticals: Designer Foods III Garlic, Soy, and Licorice. Connecticut: Food & Nutrition Press;1997. p. 177–187.
  83. 83.
    Reeve VE, Bosnic M, Rozinova E, Boehm-Wilcox C. A garlic extract protects from ultraviolet B (280–320 nm) radiation-induced suppression of contact hypersensitivity. Photochem Photobiol. 1993;58:813–7.
    Medline

aanvullend, complementair, voedingsuppletie, voeding, geradomiseerde studie, preventie, darmpoliepen, knoflookextract


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