19 maart 2015: Wellicht is dit artikel ook interessant eens te lezen: 

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11 juli 2012: cryosurgery van bottumoren - waaronder chondrosarcoma's - wordt wel toegepast, ook in Nederland in het Radboud - Nijmegen. Het volledige studieverslag van onderstaand abstract: Cryosurgery in aggressive, benign, and low-grade malignant bone tumours  is tegen betaling bij The Lancet in te zien.

Onderaan artikel hebben we het abstract van een review studie: Curettage and cryosurgery for low-grade cartilage tumors is associated with low recurrence and high function geplaatst met deeplink naar volledige studierapport dat gratis is in te zien. Plus referentielijst van geraleerde studies

16 januari 2005: Bron: Lancet Oncol. 2005 Jan;6(1):25-34.

Cryosurgery bij goedaardige, maar ook bij kleine kwaadaardige botuitzaaiingen - bottumoren voor 95% succesvol en genezend toegepast in Nijmegen, gemeten na minimaal twee jaar followup. Aldus een studiepublicatie in The Lancet van 6 januari 2005. Jammer dat het abstract zo kort en summier is want welke grootte van bottumoren werden gehanteerd staat er niet bij en ook niet of er ook botuitzaaiïngen van bv. prostaatkanker of borstkanker zijn behandeld. Toch wel een opvallend resultaat omdat de onderzoekers praten over 95 tot 100% GENEZEND effect na twee jaar. En resultaat is aldus de onderzoekers minimaal vergelijkbaar met minimale operatieve verwijdering en superieur aan uitgebreidere operatieve verwijdering die eerstelijns is voor o.a. chrondosarcomen

Cryosurgery in aggressive, benign, and low-grade malignant bone tumours.

Veth PR, Schreuder B, Beem H, Pruszczynski M, Rooy J. Departments of Orthopaedics, University Medical Centre Nijmegen, Netherlands.

Cryosurgery is a method of treatment for various tumours that induces tissue necrosis with ablative intent. It is used in benign, aggressive, and low-grade malignant bone tumours such as chondrosarcoma grade 1. We describe the history of the technique and the issues associated with cryobiology, as well as the indications, technique, complications, and results of cryosurgery. At the University Medical Centre Nijmegen, Netherlands, 302 tumours have been treated by use of cryosurgery with at least 2 years' follow-up. 96-100% of patients were cured-the response depended on tumour type. Comparison of functional results with data from studies shows that these results concur with other studies on cryosurgery, and are at least equal to results of marginal excision and mostly better than those of wide excisions of grade 1 chondrosarcomas. Thus from an oncological point of view, cryosurgery combined with intralesional excision is equal to marginal excision.

PMID: 15629273 [PubMed - in process]

Curettage with cryosurgery is associated with low recurrence of Grade 1 chondrosarcoma and high functional scores

Clin Orthop Relat Res. 2010 Oct;468(10):2765-73. Epub 2010 Jun 24.

Curettage and cryosurgery for low-grade cartilage tumors is associated with low recurrence and high function.

Mohler DG, Chiu R, McCall DA, Avedian RS.

Source

Department of Orthopaedic Surgery, Stanford University Medical Center, 450 Broadway Street, M/C 6342, Redwood City, CA 94063, USA.

Abstract

BACKGROUND:

Chondrosarcomas of bone traditionally have been treated by wide or radical excision, procedures that may result in considerable lifelong disability. Grade 1 chondrosarcomas have little or no metastatic potential and are often difficult to distinguish from painful benign enchondromas. Curettage with adjuvant cryosurgery has been proposed as an alternative therapy for Grade 1 chondrosarcomas given the generally better function after the procedure. However, because it is an intralesional procedure, curettage and cryosurgery may be associated with higher rates of recurrence.

QUESTIONS/PURPOSES:

We asked whether Grade 1 chondrosarcomas and enchondromas of uncertain malignant potential treated by curettage and cryosurgery are associated with low recurrence rates and high functional scores.

PATIENTS AND METHODS:

We retrospectively reviewed the records of 46 patients with Grade 1 chondrosarcomas and enchondromas of uncertain malignant potential treated by curettage and cryosurgery. Forty-one patients had tumors of the long bones. Patients were followed a minimum of 18 months (average, 47.2. months; range, 18-134 months) for evidence of recurrence and for assessment of Musculoskeletal Tumor Society (MSTS) functional score.

RESULTS:

Two of the 46 patients had recurrences in the original tumor site (4.3% recurrence rate), which subsequently were removed by wide excision, and both patients were confirmed to be disease-free 36 and 30 months, respectively, after the second surgery. The mean MSTS score was 27.2 of 30 points (median, 29 points).

CONCLUSIONS:

Our observations show curettage with cryosurgery is associated with low recurrence of Grade 1 chondrosarcoma and high functional scores. Curettage with cryosurgery is a reasonable alternative to wide or radical excision as the treatment for Grade 1 chondrosarcomas, and allows for more radical surgery in the event of local recurrence.

LEVEL OF EVIDENCE:

Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

PMID:
20574801
[PubMed - indexed for MEDLINE]
PMCID:
PMC3049634

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kwaadaardig, goedaardig, bottumorne, chondrosarcomen, cryosrugery


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