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15 mei 2018: lees ook dit artikel: 

https://kanker-actueel.nl/synbiotica-vooraf-en-na-operatie-van-darmkanker-voorkomt-bijna-volledig-post-operatieve-infecties-in-vergelijking-met-placebo-1-vs-9-uit-90-patienten.html

12 juni 2015: lees ook dit artikel: probiotia-melkzuurbacterien-verminderen-significant-complicaties-bij-darmkanker-operatie-en-zorgen-voor-sneller-herstel-en-korter-verblijf-in-ziekenhuis

15 oktober 2011: Bron: Aliment Pharmacol Ther 2011; 33: 50–63

Wanneer patienten met darmkanker vooraf aan een operatie een week lang probiotica - melkzuurbacteriën krijgen voorkomen ze daarmee grotendeels infecties ten gevolge van die operatie en verbetert de darmflora en bevordert daarmee sneller herstel van een normale stoelgang. Dit blijkt uit een dubbelblinde placebo gecontroleerde gerandomiseerde studie met totaal 100 darmkanker patienten. Probiotica bleek verbetering te geven alle gestelde doelen uit deze studie. Hier het abstract van de studie, maar het volledige studierapport is gratis in te zien als u hier klikt op de website van Whiley library Onderaan staat een referentielijst die aantoont dat probiotica een bewezen middel is dat veel goed doet. 

En zie ook in gerelateerde artikelen meer artikelen die de waarde van probiotica aantonen.

Probiotics can improve the integrity of gut mucosal barrier by benefiting the faecal microbiota, and decreasing infectious complications in patients with colorectal cancer undergoing colorectomy

Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery – a double-blind study

  1. Z. Liu,
  2. H. Qin,
  3. Z. Yang,
  4. Y. Xia,
  5. W. Liu,
  6. J. Yang,
  7. Y. Jiang,
  8. H. Zhang,
  9. Z. Yang,
  10. Y. Wang,
  11. Q. Zheng

Article first published online: 25 OCT 2010

DOI: 10.1111/j.1365-2036.2010.04492.x

Abstract

Aliment Pharmacol Ther 2011; 33: 50–63

Summary

Background Infection following abdominal operation remains a major factor affecting the morbidity of patients after surgery.

Aim To determine the effects of perioperative administration of probiotics on the gut barrier function and the surgical outcome in patients undergoing elective colorectal surgery.

Methods One hundred patients with colorectal carcinoma were randomly divided into the control group (n = 50) and the probiotics group (n = 50). The probiotics were given orally for 6 days preoperatively and 10 days post-operatively. Outcomes were measured by bacterial translocation, gut permeability, the effect on the faecal microbiota, and the clinical outcomes such as infectious-related complications and gut defecation function.

Results Compared with the control group, probiotics group had increased transepithelial resistance (P < 0.05), reduced transmucosal permeation of horseradish peroxidase and lactulose/mannitol ratio, reduced bacterial translocation (P < 0.05), decreased ileal-bile acid binding protein (P < 0.05) and positive rate of blood bacterial DNA (P < 0.05) and an enhanced mucosal tight junction protein expression. They had decreased blood enteropathogenic bacteria and increased faecal bacterial variety. The post-operative recovery of peristalsis, incidence of diarrhoea, and infectious-related complications were also improved.

Conclusion Probiotics can improve the integrity of gut mucosal barrier by benefiting the faecal microbiota, and decreasing infectious complications in patients with colorectal cancer undergoing colorectomy. Read here the full studyreport>>>>>

References

  • 1
    Tran KTC, Smeenk HG, Van Eijck CHJ, et al. Pylorus preserving pancreaticoduodenectomy versus standard Whipple procedure – a prospective, randomized, multicenter analysis of 170 patients with pancreatic and periampullary tumors. Ann Surg 2004; 240: 738–45.
  • 2
    Schroeder RA, Marroquin CE, Bute BP, Khuri S, Henderson WG, Kuo PC. Predictive indices of morbidity and mortality after liver resection. Ann Surg 2006; 243: 373–9.
  • 3
    MacFie J, O’Boyle C, Mitchell CJ, Buckley PM, Johnstone D, Sudworth P. Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity. Gut 1999; 45: 223–8.
  • 4
    Reddy BS, Gatt M, Sowdi R, MacFie J. Surgical manipulation of the large intestine increases bacterial translocation in patients undergoing elective colorectal surgery. Colorectal Dis 2006; 8: 596–600.
    Direct Link:
  • 5
    Saadia R, Schein M, MacFarlane C, Boffard KD. Gut barrier function and the surgeon. Br J Surg 1990; 77: 487–92.
    Direct Link:
  • 6
    Welsh FKS, Ramsden CW, MacLennan K, et al. Increased intestinal permeability and altered mucosal immunity in cholestatic jaundice. Ann Surg 1998; 227: 205–12.
  • 7
    Lilly DM, Stillwell RH. Probiotics: growth-promoting factors produced by microorganisms. Science 1965; 147: 747–8.
  • 8
    Sugawara G, Nagino M, Nishio H, et al. Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. Ann Surg 2006; 244: 706–14.
  • 9
    Lin HC, Su BH, Chen AC, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics 2005; 115: 1–4.
  • 10
    D’Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 2002; 324: 1361.
  • 11
    Parkes GC, Sanderson JD, Whelan K. The mechanisms and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhoea. Lancet Infect Dis 2009; 9: 237–44.
  • 12
    McCarthy J, O’Mahony L, Dunne C, et al. An open trial of a novel probiotic as an alternative to steroids in mild/moderately active Crohn’s disease. Gut 2001; 49: A2447.
  • 13
    Qin HL, Zheng JJ, Tong DN, et al. Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis. Eur J Clin Nutr 2008; 62: 923–30.
  • 14
    Liu Q, Duan ZP, Ha DK, Bengmark S, Kurtovic J, Riordan SM. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004; 39: 1441–9.
    Direct Link:
  • 15
    Li Z, Yang S, Lin H, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37: 343–50.
    Direct Link:
  • 16
    Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001; 357: 1076–9.
  • 17
    Woodard GA, Encarnacion B, Downey JR, et al. Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial. J Gastrointest Surg 2009; 13: 1198–204.
  • 18
    Pitsouni E, Alexiou V, Saridakis V, Peppas G, Falagas ME. Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials. Eur J Clin Pharmacol 2009; 65: 561–70.
  • 19
    Correia MI, Nicoli JR. The role of probiotics in gastrointestinal surgery. Curr Opin Clin Nutr Metab Care 2006; 9: 618–21.
  • 20
    Van Santvoort HC, Besselink MG, Timmerman HM, Van Minnen LP, Akkermans LM, Gooszen HG. Probiotics in surgery. Surgery 2008; 143: 1–7.
  • 21
    Kinross J, Von Roon AC, Penney N, et al. The gut microbiota as a target for improved surgical outcome and improved patient care. Curr Pharm Des 2009; 15: 1537–45.
  • 22
    Reddy BS, Macfie J, Gatt M, Larsen CN, Jensen SS, Leser TD. Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy. Br J Surg 2007; 94: 546–54.
    Direct Link:
  • 23
    Rayes N, Seehofer D, Theruvath T, et al. Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial. Ann Surg 2007; 246: 36–41.
  • 24
    Kanazawa H, Nagino M, Kamiya S, et al. Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy. Langenbecks Arch Surg 2005; 390: 104–13.
  • 25
    Rayes N, Seehofer D, Theruvath T, et al. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation – a randomized, double-blind trial. Am J Transplant 2005; 5: 125–30.
    Direct Link:
  • 26
    Alberda C, Gramlich L, Meddings J, et al. Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2007; 85: 816–23.
  • 27
    Besselink MG, Van Santvoort HC, Buskens E, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 371: 651–9.
  • 28
    Lieberman JM, Sacchettini J, Marks C, Marks WH. Human intestinal fatty acid binding protein: report of an assay with studies in normal volunteers and intestinal ischemia. Surgery 1997; 121: 335–42.
  • 29
    Kiliaan AJ, Saunders PR, Bijlsma PB, et al. Stress stimulates transepithelial macromolecular uptake in rat jejunum. Am J Physiol 1998; 275(5 Pt 1): G1037–44.
  • 30
    Shang S, Fu J, Dong G, Hong W, Du L, Yu X. Establishment and analysis of specific DNA patterns in 16S-23S rRNA gene spacer regions for differentiating different bacteria. Chin Med J (Engl) 2003; 116: 129–33.
  • 31
    Qin HL, Shen TY, Gao ZG, et al. Effect of lactobacillus on the gut microflora and barrier function of the rats with abdominal infection. World J Gastroenterol 2005; 11: 2591–6.
  • 32
    Schwiertz A, Gruhl B, Lobnitz M, Michel P, Radke M, Blaut M. Development of the intestinal bacterial composition in hospitalized preterm infants in comparison with breast-fed, full-term infants. Pediatr Res 2003; 54: 393–9.
  • 33
    Qin H, Zhang Z, Hang X, Jiang YL. Plantarum prevents enteroinvasive Escherichia coli-induced tight junction proteins changes in intestinal epithelial cells. BMC Microbiol 2009; 9: 63.
  • 34
    McNaught CE, Woodcock NP, MacFie J, Mitchell CJ. A prospective randomised study of the probiotic Lactobacillus plantarum 299V on indices of gut barrier function in elective surgical patients. Gut 2002; 51: 827–31.
  • 35
    Anderson AD, McNaught CE, Jain PK, MacFie J. Randomised clinical trial of synbiotic therapy in elective surgical patients. Gut 2004; 53: 241–5.
  • 36
    Resta-Lenert S, Barrett KE. Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC). Gut 2003; 52: 988–97.
  • 37
    Resta-Lenert S, Barrett KE. Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Gastroenterology 2006; 130: 731–46.
  • 38
    Madsen K, Cornish A, Soper P, et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 2001; 121: 580–91.
  • 39
    Mennigen R, Nolte K, Rijcken E, et al. Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 2009; 296: G1140–9.
  • 40
    Zareie M, Johnson-Henry K, Jury J, et al. Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress. Gut 2006; 55: 1553–60.
  • 41
    Ewaschuk J, Endersby R, Thiel D, et al. Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis. Hepatology 2007; 46: 841–50.
    Direct Link:
  • 42
    Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003; 361: 512–9.
  • 43
    Jain PK, McNaught CE, Anderson AD, MacFie J, Mitchell CJ. Influence of synbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactis Bb 12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: a randomised controlled trial. Clin Nutr 2004; 23: 467–75.
  • 44
    Konstantinov SR, Awati A, Smidt H, Williams BA, Akkermans AD, De Vos WM. Specific response of a novel and abundant Lactobacillus amylovorus-like phylotype to dietary prebiotics in the guts of weaning piglets. Appl Environ Microbiol 2004; 70: 3821–30.
  • 45
    Langlands SJ, Hopkins MJ, Coleman N, Cummings JH. Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel. Gut 2004; 53: 1610–6.

darmkanker, infecties, operatie, melkzuurbacteriën, probiotica


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