Zie ook: ALFYTAL module suppletie, deze sponsor uit onze reclamecaroussel levert al heel lang voedingsupplementen van hoge kwaliteit tegen heel acceptabele prijzen. Zoals pure broccolisprouts. 

25 augustus 2025: zie ook dit artikel: https://kanker-actueel.nl/broccoli-blijkt-risico-op-kanker-sterk-te-verminderen-blijkt-uit-meta-analyse-van-37-studies-waaronder-23-case-control-studies.html

25 augustus 2025: Bron: BMC Gastroenterology volume 25, Article number: 575 (2025)

Uit een meta analyse van 17 studies met in totaal 639.539 deelnemers blijkt dat mensen die heel regelmatig kruisbloemige groenten zoals broccoli, bloemkool, spruitjes en kool aten de kans op het krijgen van vormen van darmkanker met tot 20 procent minder wordt. In vergelijking met mensen die weinig of geen van deze groenten aten. Als een of meerdere van de kruisbloemige groenten 20 tot 40 gram van het dagelijks eten bevatte gaf dit de beste preventieve resultaten op de risicovermindering voor het ontstaan van darmkanker. Boven de 60 gram gaf dit geen hoger beschermend effect meer.

Including brocolli in one's diet can have a protective effect against colon cancer, finds a recent study

Naast een rijke bron van gunstige fytochemicaliën, waaronder flavonoïden, vezels, vitamine C en carotenoïden, zitten kruisbloemige groenten ook boordevol glucosinolaten. Bij het kauwen worden deze verbindingen afgebroken tot bioactieve isothiocyanaten, met name sulforafaan (SFN) – een molecuul dat niet alleen verantwoordelijk is voor de sterke, kenmerkende geur van de groenten, maar ook voor hun beschermende, chemopreventieve effecten. Isothiocyanaten spelen een beschermende rol tegen kanker via verschillende mechanismen: ze kunnen enzymen / eiwitten blokkeren die kankerverwekkende stoffen activeren, apoptose (geprogrammeerde celdood) in kwaadaardige cellen op gang brengen, de vorming van nieuwe bloedvaten in tumoren remmen en de celcyclus stopzetten, waardoor ongecontroleerde groei van kankercellen wordt voorkomen.

Het volledige studierapport is gratis in te zien of te downloaden. Klik daarvoor op de titel van het abstract:
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Cruciferous vegetables intake and risk of colon cancer: a dose–response meta-analysis

BMC Gastroenterology volume 25, Article number: 575 (2025) Cite this article

Abstract

Background

Colon cancer (CC) is the third most diagnosed malignancy and second leading cause of cancer mortality globally, with ~ 1.9 million new cases and 903,859 deaths annually (Bray et al. in CA Cancer J Clin 68(6):394–424, 2018). Diet represents a key modifiable risk factor for CC pathogenesis (Herr and Buchler in Cancer Treat Rev 36:377–383, 2010). Cruciferous vegetables (CV)—rich in glucosinolates that hydrolyze into bioactive isothiocyanates (Willett in Cancer Epidem Biomar 10:3–8, 2001; Murillo and Mehta in Nutr Cancer. 41(1–2):17–28, 2001; Higdon et al. in Pharmacol Res 55:224–36, 2007)—exhibit chemopreventive properties through carcinogen detoxification, apoptosis induction, and cell cycle arrest (Zhang et al. in Proc Nutr Soc 65:68–75, 2006). While prior meta-analyses report an inverse association between CV intake and CC risk (Tse and Eslick in Nutr Cancer 66(1):128–39, 2014), the quantitative dose–response relationship remains uncharacterized, limiting translational insights for dietary guidance.

Methods

A thorough search of the literature was conducted in Embase, Scopus,Web of Science, PubMed, and Cochrane Library from inception to June 28, 2025, using a predetermined strategy encompassing both cohort and case–control studies. Two independent reviewers selected studies based on predefined inclusion criteria, with discrepancies resolved by consensus or senior investigator adjudication. Statistical analyses were performed using Stata (version 14.2). Subgroup analyses accounted for study design, geographic location, and potential confounders. Publication bias was assessed using Egger's test, the LFK index, and the trim-and-fill method. Sensitivity analyses employed the leave-one-out approach. The dose–response relationship was evaluated using restricted cubic spline models.

Results

Data from 17 research—including 7 cohort studies and 10 case–control studies—with 97,595 patients were methodically combined in this investigation.Consumption of CV was found to be inversely correlated with CC risk (odds ratios  = 0.8; 95% confidence interval 0.72–0.90) in the pooled analysis using a random-effects model. Furthermore, a progressive decrease in risk was shown by the non-linear dose–response analysis as consumption levels increased.

Conclusion

This meta-analysis suggests a potential inverse association between higher CV intake and CC incidence. However, these findings should be interpreted cautiously due to methodological limitations, including heterogeneity in study designs, dietary assessment methods and potential residual confounding.

Peer Review reports

Data availability

Data is provided within the manuscript or supplementary information files.

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Acknowledgements

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Funding

All authors announced that they had not received any fund support.

Author information

Authors and Affiliations

  1. Department of Interventional Radiology, Inner Mongolia Forestry General Hospital, The Second Clinical Medical School of Inner Mongolia University for the Nationalities, No.81, Lincheng Road, 022150, Yakeshi, China

    Bo Lai & Junjie Li

  2. Department of Medical Imaging, Inner Mongolia Forestry General Hospital, The Second Clinical Medical School of Inner Mongolia University for the Nationalities, Yakeshi, China

    Zhong Li

Contributions

(I) Conception and design:Bo Lai. (II) Administrative support:Zhong Li. (III) Provision of study materials or patients:Junjie Li. (IV) Collection and assembly of data:Bo Lai. (V) Data analysis and interpretation:Bo Lai. (VI) Manuscript writing: Bo Lai,Zhong Li,Junjie Li. (VII) Final approval of manuscript: Bo Lai, Zhong Li, Junjie Li

Corresponding author

Correspondence to Junjie Li.

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As this meta-analysis exclusively synthesized aggregated data from previously published studies, no direct involvement of human participants occurred. Consequently, neither ethics re-approval nor additional informed consent was required, in accordance with international guidelines for evidence synthesis research. All original studies included in this analysis declared compliance with ethical standards in their respective publications, including appropriate ethics board approvals and participant consent procedures.An ethics statement is not applicable because this study is based exclusively on published literature. The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Lai, B., Li, Z. & Li, J. Cruciferous vegetables intake and risk of colon cancer: a dose–response meta-analysis. BMC Gastroenterol 25, 575 (2025). https://doi.org/10.1186/s12876-025-04163-9

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Keywords

kool, broccoli, bloemkool, spruitjes, preventie, darmkanker, meta analyse, kruisbloemige groenten


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